Age-related changes in the hemostasis system
https://doi.org/10.34651/0023-2149-2020-98-1-9-12
Abstract
Myocardial infarction, stroke and venous thromboembolism, which are based on vascular thrombosis, are the leading causes of death in the entire world. Most often, these diseases develop with the aging of the human body. With age, changes in the hemocoagulation system occur, such as an increase in the level of fibrinogen, factors VIII and IX and other procoagulants without a proportional increase in anticoagulant factors, a decrease in the number of platelets and an increase in their activity, a decrease in the activity of fibrinolysis, and endothelial dysfunction develops. All this leads to an increase in the intensity of intravascular coagulation and the development of thrombosis.
About the Authors
E. V. Kryukov
Burdenko Main Military Clinical Hospital
Russian Federation
Russian Federation
Eugeniy V. Kryukov — MD, PhD, DSc, professor, corresponding member RAS, head of the hospital
Moscow
T. S. Panevin
Burdenko Main Military Clinical Hospital
Russian Federation
Moscow
Russian Federation
Moscow
L. V. Popova
I.M. Sechenov First Moscow State Medical University
Russian Federation
Moscow
Russian Federation
Moscow
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For citations:
Kryukov E.V., Panevin T.S., Popova L.V. Age-related changes in the hemostasis system. Clinical Medicine (Russian Journal). 2020;98(1):9-12. (In Russ.) https://doi.org/10.34651/0023-2149-2020-98-1-9-12
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