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Atypical hemolytic-uremic syndrome
https://doi.org/10.30629/0023-2149-2025-103-12-921-926
Abstract
A clinical case of atypical hemolytic uremic syndrome in an adult man is presented. Atypical hemolytic uremic syndrome (aHUS) is an orphan disease that affects various organs and systems and is accompanied by extremely high mortality. aHUS is based on uncontrolled activation of the alternative complement pathway, leading to generalized thrombus formation in the vessels of the microcirculatory bed. High mortality in aHUS is due to several reasons: extremely rare incidence of the disease and, as a result, low awareness of it by doctors, nonspecific symptoms at the onset of aHUS, rapid development of multiple organ failure with kidney damage due to catastrophic generalized thrombus formation in the microcirculatory bed.
About the Authors
V. V. Eirih
Tyumen State Medical University ; Tyumen Regional Clinical Hospital №1
Russian Federation
Russian Federation
Victoria V. Eirih — Nephrologist of OKB No. 1, postgraduate student of the Department of Propaedeutics of Internal Diseases
Tyumen
N. V. Tolstoukhova
Tyumen Regional Clinical Hospital №1
Russian Federation
Russian Federation
Natalia V. Tolstoukhova — Candidate of Medical Sciences Doctor of Sciences, Head of the Department of Nephrology
Tyumen
V. A. Zhmurov
Tyumen State Medical University
Russian Federation
Russian Federation
Vladimir A. Zhmurov — Doctor of Medical Sciences, Professor, Head of the Department of Propaedeutics of Internal Diseases, Institute of Clinical Medicine
Tyumen
A. A. Kutasov
Tyumen State Medical University
Russian Federation
Russian Federation
Alexey A. Kutasov — 5th year student of the Institute of Clinical Medicine
Tyumen
References
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Review
For citations:
Eirih V.V., Tolstoukhova N.V., Zhmurov V.A., Kutasov A.A. Atypical hemolytic-uremic syndrome. Clinical Medicine (Russian Journal). 2025;103(12):921-926. (In Russ.) https://doi.org/10.30629/0023-2149-2025-103-12-921-926
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