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C-reactive protein as a laboratory criterion of the traumaticity of cardiac surgical interventions
https://doi.org/10.30629/0023-2149-2025-103-5-369-373
Abstract
The purpose of this study is to determine the possibility of using the level of C-reactive protein (CRP) as a quantitative criterion for injury during open-heart surgery using a cardiopulmonary bypass machine, as well as to evaluate the correlation of CRP and the time of cardiopulmonary bypass (CPB), the time of myocardial ischemia.
Material and methods. A prospective nonrandomized cohort study was conducted to determine CRP at 4 stages of inpatient treatment and the correlation of CRP, cardiopulmonary bypass time and myocardial ischemia time was assessed in 108 patients who underwent open-heart surgery.
Results. In the postoperative period, the content of CRP in the blood serum of cardiac surgery patients statistically significantly increases after 24 hours, reaching maximum values on the 3rd day after surgery. When analyzing the correlation between the level of CRP 24 hours after surgery, the time of cardiopulmonary bypass and the time of myocardial ischemia, no statistically significant results were obtained.
Conclusion. In patients who underwent open-heart surgery using a cardiopulmonary bypass apparatus, an increase in CRP levels was noted from 2.7 (1.2; 5.82) to 174.5 (109.9; 253.3) mg/l after 68–72 hours after surgery. The dynamics of CRP content in patients undergoing cardiac surgery can be considered as a laboratory criterion for the morbidity of surgical intervention. There is no correlation between the level of CRP 24 hours after surgery, the time of cardiopulmonary bypass and the time of myocardial ischemia.
About the Authors
M. S. Kurashov
Health Care Institution «Mogilev Regional Clinical Hospital»
Belarus
Belarus
Mikhail S. Kurashov – cardiac surgeon of the Department of Cardiac Surgery
Mogilev
A. V. Marochkov
Health Care Institution «Mogilev Regional Clinical Hospital»; Educational Establishment «Vitebsk State Order of Peoples’ Friendship Medical University»
Belarus
Belarus
Alexey V. Marochkov – Doctor of Medical Sciences, Professor, branch of the Department of Anesthesiology and Intensive Care Unit with a course of FPC and PC and hospital surgery with a course of FPC and PC; anesthesiologist-intensive care unit of the Department of Anesthesiology and Intensive Care Unit
Mogilev;
Vitebsk
A. S. Kulik
Health Care Institution «Mogilev Regional Clinical Hospital»
Belarus
Belarus
Anatoly S. Kulik – Chief Physician
Mogilev
V. N. Levanovich
Health Care Institution «Mogilev Regional Clinical Hospital»
Belarus
Belarus
Vadim N. Levanovich – cardiac surgeon, Head of the Department of Cardiac Surgery
Mogilev
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Review
For citations:
Kurashov M.S., Marochkov A.V., Kulik A.S., Levanovich V.N. C-reactive protein as a laboratory criterion of the traumaticity of cardiac surgical interventions. Clinical Medicine (Russian Journal). 2025;103(5):369-373. (In Russ.) https://doi.org/10.30629/0023-2149-2025-103-5-369-373
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