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Trajectories of long-term outcome of heart failure with concomitant chronic kidney disease: the significance of high-sensitivity C-reactive protein
https://doi.org/10.30629/0023-2149-2024-102-11-12-880-887
Abstract
Inflammation is intimately associated with atherosclerotic disease, including in patients with chronic heart failure (CHF), and high-sensitivity C-reactive protein (hsCRP) levels play a key role in determining severity and outcome.
Objective: to study the potential of serum hsCRP for predicting the outcome of ischemic heart failure in the presence of chronic kidney disease (CKD).
Material and methods. Clinical signs and 5-year outcomes of patients with CHF (n = 517), including those in combination with CKD (n = 207), were studied.
Results and conclusions. The phenotype of CHF in combination with CKD was characterized by female gender, older age, a higher prevalence of arterial hypertension, diabetes mellitus, previous myocardial infarction and coronary intervention, lower cardiorespiratory endurance, higher levels of hsCRP (p = 0.005), low-density lipoprotein cholesterol (p = 0.021), non-high-density lipoprotein cholesterol (p = 0.015). Patients with CHF with hsCRP > 3 mg/L have a higher 5-year risk of death from any cause, cardiovascular death, and achieving the composite endpoint (CCT). An increase in hsCRP for every 1 mg/l in CHF increases the risk of death from all causes (HR = 1.1; 95% CI 0.99–1.21), cardiovascular death (HR = 1.11; 95% CI 1.01–1.23). Death from any cause and cardiovascular death with CHF, incl. in the presence of CKD, hsCRP > 3.07 mg/l was predicted. Achieving CCT was predicted in patients with CHF with hsCRP > 2.69 mg/l, in patients with a combination of CHF and CKD — with hsCRP > 2.5 mg/l.
About the Authors
E. V. Khazova
Kazan State Medical University
Russian Federation
Russian Federation
Elena V. Khazova — Candidate of Medical Sciences, Associate Professor of the Department of propaedeutics of internal diseases named after professor S.S. Zimnitsky
Scopus Author ID: 57205153574
ResercherID O-2336-2016
RSCI AuthorID 639552
Kazan
O. V. Bulashova
Kazan State Medical University
Russian Federation
Russian Federation
Olga V. Boulashova — Doctor of Medical Sciences, Professor of the Department of propaedeutics of internal diseases named after professor S.S. Zimnitsky
Scopus Author ID: 6507198087
RSCI AuthorID 46110692
Kazan
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Review
For citations:
Khazova E.V., Bulashova O.V. Trajectories of long-term outcome of heart failure with concomitant chronic kidney disease: the significance of high-sensitivity C-reactive protein. Clinical Medicine (Russian Journal). 2024;102(11-12):880-887. (In Russ.) https://doi.org/10.30629/0023-2149-2024-102-11-12-880-887
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