Modern methods of non-invasive diagnosis and prevention of melanoma

This article discusses modern non-invasive methods for diagnosing melanoma and its prevention. The use of contemporary non-invasive diagnostic techniques significantly improves the accuracy of clinical diagnosis, which facilitates the early detection of malignant skin tumors and reduces the need for unnecessary surgical interventions. The focus is on advanced technologies that allow for the detection of the disease at early stages, which substantially increases the chances of successful treatment and decreases the risk of mortality.

Objective. The aim of this work is to analyze and evaluate the effectiveness of modern non-invasive methods for diagnosing melanoma and preventive measures aimed at reducing the frequency of late diagnoses and increasing public awareness of the risks of the disease.

Material and methods. The article analyzes methods such as dermatoscopy, confocal microscopy, optical coherence tomography, and other innovative techniques like quantitative infrared thermography.

The results of the study show that the application of non-invasive diagnostic methods significantly enhances the accuracy of melanoma detection at early stages, contributing to a reduction in mortality and a decrease in unnecessary surgical interventions.

Conclusion. Late diagnosis of melanoma often leads to diagnostic errors by specialists in various fields and to the ineffectiveness of the therapy provided. Preventive measures, including primary and secondary prevention methods, are crucial aspects of reducing the risk of melanoma occurrence and increasing public awareness of possible protective measures.

1. Ebert M.A., Gafton G.I., Zinoviev G.V., Gafton I.G. Modern view on the diagnosis of skin melanoma. Oncology issues. 2019;65(5):638–644. (In Russian).

2. Chebotarev V.V., Khismatullina Z.R., Zakirova Y.A. Some Aspects of the Epidemiology and Diagnostics of Malignant Skin Neoplasms. Creative surgery and oncology. 2020;10(1):65–73. (In Russian). DOI: 10.24060/2076-3093-2020-10-1-65-73

3. Myasnyankin M.Yu. New possibilities of the non-invasive method of bioimpedance diagnostics of skin melanoma. Malignant tumors. 2021;12(3S1). (In Russian).

4. Lazarev Yu.D. Modern methods of diagnosis and treatment of melanoma. Medicine. Sociology. Philosophy. Applied research. 2018;3:6–10. (In Russian).

5. Yargunin S.A., Lazarev A.F. Melanoma of the skin. state of the problem. review. Russian Journal of Oncology. 2019;24(3-6):113– 120. (In Russian). DOI: 10.18821/1028-9984-2019-24-3-6-113-120

6. Clinical recommendations. Melanoma of the skin of the mucous membranes. ICD 10: C43, C51, C60.9, C63.2 (In Russian).

7. Garanina O.E., Samoylenko I.V., Shlivko I.L., Klemenova I.A., Neznakhina M.S., Demidov L.V. Noninvasive diagnostic techniques for skin tumors and their potential for use in skin melanoma screening: a systematic literature review. Meditsinskiy sovet = Medical Council. 2020;(9):102–120. (In Russian). DOI: 10.21518/2079-701X-2020-9-102-120

8. Ahmed B., Qadir M.I., Ghafoor S. Malignant Melanoma: Skin Cancer-Diagnosis, Prevention, and Treatment. Crit. Rev. Eukaryot. Gene Expr. 2020;30(4): –-297. DOI: 10.1615/CritRevEukaryotGeneExpr.2020028454

9. Long G.V., Swetter S.M., Menzies A.M., Gershenwald J.E., Scolyer R.A. Cutaneous melanoma. Lancet. 2023;402(10400):485–502. DOI: 10.1016/S0140-6736(23)00821-8

10. Bobos M. Histopathologic classification and prognostic factors of melanoma: a 2021 update. Ital. J. Dermatol. Venerol. 2021;156(3):300–321. DOI: 10.23736/S2784-8671.21.06958-3

11. Teixido C., Castillo P., Martinez-Vila C., Arance A., Alos L. Molecular Markers and Targets in Melanoma. Cells. 2021;10(9):2320. DOI: 10.3390/cells10092320

12. Dzwierzynski W.W. Melanoma Risk Factors and Prevention. Clin. Plast. Surg. 2021;48(4):543–550. DOI: 10.1016/j.cps.2021.05.001

13. Garbe C., Amaral T., Peris K., Hauschild A., Arenberger P., Basset-Seguin N. et al. European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO), and the European Organization for Research and Treatment of Cancer (EORTC). European consensus-based interdisciplinary guideline for melanoma. Part 1: Diagnostics: Update 2022. Eur. J. Cancer. 2022;170:236– 255. DOI: 10.1016/j.ejca.2019.11.014

14. Tímár J., Ladányi A. Molecular Pathology of Skin Melanoma: Epidemiology, Differential Diagnostics, Prognosis and Therapy Prediction. Int. J. Mol. Sci. 2022;23(10):5384. DOI: 10.3390/ijms23105384

15. Eddy K., Chen S. Overcoming Immune Evasion in Melanoma. Int. J. Mol. Sci. 2020;21(23):8984. DOI: 10.3390/ijms21238984

16. Randic T., Kozar I., Margue C., Utikal J., Kreis S. NRAS mutant melanoma: Towards better therapies. Cancer Treat. Rev. 2021;99:102238. DOI: 10.1016/j.ctrv.2021.102238

17. Gregg R.K. Model Systems for the Study of Malignant Melanoma. Methods Mol. Biol. 2021;2265:1–21. DOI: 10.1007/978-1-0716-1205-7_1

18. Rashid S., Shaughnessy M., Tsao H. Melanoma classification and management in the era of molecular medicine. Dermatol. Clin. 2023;41(1):49–63. DOI: 10.1016/j.det.2022.07.017

19. Marghoob N.G., Liopyris K., Jaimes N. Dermoscopy: A Review of the Structures That Facilitate Melanoma Detection. J. Am. Osteopath. Assoc. 2019;119(6):380–390. DOI: 10.7556/jaoa.2019.067

20. Salerni G., Carrera C., Lovatto L., Puig-Butille J.A., Badenas C., Plana E. Benefits of total body photography and digital dermatoscopy (“twostep method of digital follow-up”) in the early diagnosis of melanoma in patients at high risk for melanoma. JAAD. 2012;67(1):e17–27. DOI: 10.1016/j.jaad.2011.04.008

21. Pampena R., Piccolo V., Muscianese M., Kyrgidis A., Lai M., Russo T., Briatico G.et al. Melanoma in children: A systematic review and individual patient meta-analysis. J. Eur. Acad. Dermatol Venereol. 2023;37(9):1758–1776. DOI: 10.1111/jdv.19220

22. Shrivastava V., Bailin P., Elliott J., Bacnik E., Gastman B., Bergfeld W. et al. Histopathologic correlation of high-risk MelaFind(TM) lesions: a 3-year experience from a high-risk pigmented lesion clinic. Int. J. Dermatol. 2019;58(5):569–576. DOI: 10.1111/ijd.14336

23. Романова О.А., Артемьева Н.Г., Безлепко М.Г. Низкая информированность поликлинических врачей – причина запущенности поверхностно-распространяющейся меланомы кожи. Лечащий Врач. 2021;5(24):38–42. DOI: 10.51793/OS.2021.32.63.008

24. de Giorgi V., Stante M., Massi D., Mavilia L., Cappugi P., Carli P. Possible histopathologic correlates of dermoscopic features in pigmented melanocytic lesions identified by means of optical coherence tomography. Exp. Dermatol. 2005;14(1):56–59. DOI: 10.1111/j.0906-6705.2005.00229.x

25. Ruffolo A.M., Sampath A.J., Kozlow J.H., Neumeister M.W. Melanoma of the Hands and Feet (With Reconstruction). Clin. Plast. Surg. 202;48(4):687–698. DOI: 10.1016/j.cps.2021.05.009

26. Абдурахманов А.К., Тонкачева А.А. Диагностика меланомы кожи. Обзор литературы. Бюллетень медицинских интернет-конференций. 2021;11(1):5-6.

27. Pezzini C., Kaleci S., Chesterc J., Farnetani F., Longo C., Pellacani G. Reflectance confocal microscopy diagnostic accuracy for malignant melanoma in different clinical settings: systematic review and meta-analysis. Journal of the European Academy of Dermatology and Venereology: JEADV. 2020;34(10):2268–2279. DOI: 10.1111/jdv.16248

28. Dinnes J., Deeks J.J., Saleh D., Chuchu N., Bayliss S.E., Patel L. Reflectance confocal microscopy for diagnosing cutaneous melanoma in adults. Cochrane Database Syst. Rev. 2018;(12):Cd013190. DOI: 10.1002/14651858.CD013190

29. Kościelecka K., Kubik-Machura D., Kuć A., Furmanek F., Męcik-Kronenberg T. Melanoma during pregnancy as a complicated medical problem. Obstet. Gynecol. Surv. 2023;78(2):115–123. DOI: 10.1097/OGX.0000000000001109

30. Sun L., Arbesman J. Canonical signaling pathways in melanoma. Clin. Plast. Surg. 2021;48(4):551–560. DOI: 10.1016/j.cps.2021.05.002

31. Harland C.C., Kale S.G., Jackson P., Mortimer P.S., Bamber J.C. Differentiation of common benign pigmented skin lesions from melanoma by high-resolution ultrasound. BJD. 2000;143(2):281– 289. DOI: 10.1046/j.1365-2133.2000.03652.x

32. Белышева Т.С., Вишневская Я.В., Волкова А.С., Валиев Т.Т., Михайлова С.Н., Поляков В.Г. Случай ложноположительной диагностики меланомы кожи у ребенка. Российский журнал детской гематологии и онкологии. 2021;8(2):103–107. DOI: 10.21682/2311-1267-2021-8-2-103-102

33. Неретин Е.Ю., Козлов С.В., Золотарева Т.Г. Медико-организационные подходы к ранней диагностике меланомы кожи. Здравоохранение РФ. 2021;65(6):557–564. DOI: 10.47470/0044-197X-2021-65-6-SS7-564

34. Herman C. The role of dynamic infrared imaging in melanoma diagnosis. Expert. Review of Dermatology. 2013;8(2):177–184. DOI: 10.1586/edm.13.15

35. Yao Z., Allen T., Oakley M., Samons C., Garrison D., Jansen B. Analytical Characteristics of a Noninvasive Gene Expression Assay for Pigmented Skin Lesions. Assay Drug. Dev. Technol. 2016;14(6):355–363. DOI: 10.1089/adt.2016.724

36. Потекаев Н.Н., Миченко А.В., Львов А.Н. Первичная и вторичная профилактика меланомы кожи: аналитический обзор. Профилактическая медицина. 2018;21(5):136–143. DOI: 10.17116/profmed201821051136