Effectiveness of complex treatment of tube-peritoneal infertility with the use of immunomodulatory therapy

Objective: To evaluate the effectiveness of comprehensive treatment for tubo-peritoneal infertility using immunomodulators and to compare the results obtained with literature data presenting classical therapy schemes for this type of infertility. Material and Methods: A retrospective study using a targeted sampling method. A total of 97 protocols for laparoscopic surgeries on patients with a clinical diagnosis of “Female infertility of tube-peritoneal origin. Chronic salpingitis and oophoritis” were examined. Results: Pregnancy occurred in 77.3% of patients, with 69.4% conceiving within the first year after surgery, and among these, 44.2% within the first 6 months (p < 0.05). Conclusions: As a result of comprehensive treatment using active immunomodulatory therapy, pregnancy occurred in 77.3% of cases, which is a statistically significant indicator for this sample (p < 0.05) and reflects the high effectiveness of the therapy conducted. Based on the results obtained, it is possible to state a significant impact of active immunotherapy on the outcomes of treatment for female infertility associated with the tubal factor. This is most clearly visible when compared with literature data, where in classical treatment schemes, the pregnancy rate within one year varied from 38 to 44% (whereas in the first year after therapy, pregnancy occurred in only 13–15% of cases).

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