The effect of standard lipid-lowering therapy and the type of stent on the course of the atherosclerotic process in the coronary arteries in patients with hereditary hypercholesterolemia and acute coronary syndrome

Objective. Тo study the impact of standard hypolipidemic therapy and stent type on the progression of atherosclerosis in coronary arteries in patients with familial hypercholesterolemia and acute coronary syndrome. Material and methods. Analyzed treatment results of 100 patients with familial hypercholesterolemia and acute coronary syndrome, divided into two equal groups. Group 1 received bare-metal stents, while Group 2 received drug-eluting stents. All patients were prescribed standard hypolipidemic therapy to reduce restenosis risk and normalize lipid profiles. Immediate postoperative outcomes included coronary flow restoration and adverse event rates, with long-term assessments focused on lipid profile dynamics and restenosis rates. Results. Coronary flow was restored in 98%, with adverse events occurring in 8% equally across both groups. Hypolipidemic therapy normalized lipid profiles in one-third of patients after 1 month, half after 3 months, and two-thirds after 6 months. Restenosis rates at 6 months were 45.2% in Group 1 and 21.2% in Group 2, escalating to 84.6% and 48% at 12 months. Repeat stent implantation occurred in 14% of Group 1 and 8% of Group 2. Conclusion. Standard hypolipidemic therapy is insufficient for rapid lipid normalization, while drug-eluting stents significantly reduce restenosis risk.

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