Уровень пресепсина у больных тяжелой пневмонией и пневмогенным сепсисом на гемодиализе

Abstract

2 Altai Regional Clinical Hospital, 656024, Barnaul, Russia

The aim of this study was to evaluate presepsin to improve diagnosis of severe pneumonia, sepsis in patients on hemodialysis.

Material and methods. 62 patients with severe pneumonia, sepsis, chronic glomerulonephritis and nephropathy aged from 17 to 77 years were examined. Among them were 19 patients who received hemodialysis. These patients have been investigated for the level of the presepsin. Presepsin level was quantified on immunohemilyuministsentny analyzer Pathfast (Mitsubishi Chemical Medience Corporation, Japan) in pg/ml.

Results. Рresepsin at the group of patients with severe pneumonia who received hemodialysis was 6587.9 ± 2011.09 pg/ml (n = 7), рresepsin at the group of patients with pneumogenic sepsis who received hemodialysis was 6931.1 ± 820.46 pg/ml (n = 7). Рresepsin at the group of patients with chronic glomerulonephritis and nephropathy who received hemodialysis was 1693.0 ± 248.24 pg/ml (n = 5). There was no difference between the presepsin level at the groups of patients with severe pneumonia, pneumogenic sepsis who received hemodialysis. The presepsin at the group of patients with severe pneumonia, pneumogenic sepsis who received hemodialysis was above the the level of presepsin at the group of patients with chronic glomerulonephritis and nephropathy who received hemodialysis.

Conclusion. The high level of presepsin is an indication of an active infectious disease and the effect of hemodialysis.