Clinical significance hyperimmunoglobulin Е syndrome
https://doi.org/10.30629/0023-2149-2020-98-6-419-423
Abstract
Heterogeneity of immuno-inflammatory diseases pathogenesis has been revealed with high concentration of immunoglobulin E in some nosological forms, which requires further study.
Aim. To analyze literature data, to present retrospective analysis and personal observations of patients with high concentration of IgE in the blood.
Material and methods. In 7 patients with autoinflammatory diseases and 130 rheumatic patients, examined earlier, the analysis of IgE concentration has been carried out by radio-immune method or by immune-enzyme analysis.
Results. Clinical observations of patients with derated immunoglobulin E syndrome are represented. The possibilities of genetic analysis and the connection of the derated IgE syndrome with vascular dysfunctions in rheumatic diseases are discussed.
Conclusion. When making diagnosis is complicated in patients with inflammatory syndrome of unclear etiology and high IgE concentration in the blood, it is necessary to keep in mind the autoinflammatory genesis of this process. Further study of the role of the derated immunoglobulin E syndrome in pathogenesis is required.
About the Authors
N. P. Shilkina
Yaroslavl State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Nataliya P. Shilkina — MD, PhD, DSc, prof. head of the Department of propaedeutics of internal diseases
150000, Yaroslavl
I. V. Dryazhenkova
Railway Clinical Hospital at the Yaroslavl Station, OAO «RZhD»,
Russian Federation
150030, Yaroslavl
Russian Federation
150030, Yaroslavl
I. V. Masina
Yaroslavl State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
150000, Yaroslavl
Russian Federation
150000, Yaroslavl
A. A. Vinogradov
Yaroslavl State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
150000, Yaroslavl
Russian Federation
150000, Yaroslavl
I. E. Yunonin
Yaroslavl State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
150000, Yaroslavl
Russian Federation
150000, Yaroslavl
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Review
For citations:
Shilkina N.P., Dryazhenkova I.V., Masina I.V., Vinogradov A.A., Yunonin I.E. Clinical significance hyperimmunoglobulin Е syndrome. Clinical Medicine (Russian Journal). 2020;98(6):419-423. (In Russ.) https://doi.org/10.30629/0023-2149-2020-98-6-419-423
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