Endometrioid carcinoma in a patient with a complete doubling of uterus
I. S. Zakharov,
A. A. Schmidt,
V. G. Borshchevskiy,
D. V. Solomko,
Yu. L. Timoshkova,
S. V. Beskrovniy,
V. S. Bondareva https://doi.org/10.30629/0023-2149-2023-101-1-68-72
Abstract
One of the most common variants of malignant neoplasms of the female reproductive system is endometrial cancer. At the same time, cases of this disease in patients with genital abnormalities are extremely rare in the general structure of female oncopathology. The article presents clinical cases of endometrioid carcinoma in a 75-year-old woman with doubling of uterus. According to the clinical picture, the results of ultrasound, magnetic resonance imaging and histological examination of endometrial scraping, the following diagnosis was made: cancer of the doubled uterus IB (cT1bNxM0) G2 (morphological type — endometrioid carcinoma). The surgery was performed: laparotomy, modified extended extirpation of the uterus with appendages of level B2 with pelvic lymph node dissection C3, omentectomy. The result of postoperative histological examination confirmed the preoperative diagnosis. The postoperative period was uneventful. The presented rare clinical case demonstrates the need to increase clinical suspicion in relation to patients with abnormalities of the uterus structure. Timely diagnosis and verification of the diagnosis will allow to provide adequate treatment, which will affect the prognosis of survival.
About the Authors
I. S. Zakharov
Military Medical Academy named after S.M. Kirov of the Ministry of Defense of Russia
Russian Federation
Russian Federation
Zakharov Igor S.
194044, Saint Petersburg
A. A. Schmidt
Military Medical Academy named after S.M. Kirov of the Ministry of Defense of Russia
Russian Federation
Russian Federation
Schmidt Andrey A.
194044, Saint Petersburg
V. G. Borshchevskiy
Military Medical Academy named after S.M. Kirov of the Ministry of Defense of Russia
Russian Federation
Russian Federation
Borshchevskiy Viktor G.
194044, Saint Petersburg
D. V. Solomko
Military Medical Academy named after S.M. Kirov of the Ministry of Defense of Russia
Russian Federation
Russian Federation
Solomko Dmitry V.
194044, Saint Petersburg
Yu. L. Timoshkova
Military Medical Academy named after S.M. Kirov of the Ministry of Defense of Russia
Russian Federation
Russian Federation
Timoshkova Yulia L.
194044, Saint Petersburg
S. V. Beskrovniy
Military Medical Academy named after S.M. Kirov of the Ministry of Defense of Russia
Russian Federation
Russian Federation
Beskrovniy Sergey V.
194044, Saint Petersburg
V. S. Bondareva
Military Medical Academy named after S.M. Kirov of the Ministry of Defense of Russia
Russian Federation
Russian Federation
Bondareva Valeria S.
194044, Saint Petersburg
References
1. Saravelos S.H., Cocksedge K.A., Li T.C. Prevalence and diagnosis of congenital uterine anomalies in women with reproductive failure: a critical appraisal. Hum. Reprod. Update. 2008;14(5):415–429. DOI: 10.1093/humupd/dmn018
2. Grimbizis G.F., Camus M., Tarlatzis B.C., Bontis J.N., Devroey P. Clinical implications of uterine malformations and hysteroscopic treatment results. Hum. Reprod. Update. 2001;7(2):161–174. DOI: 10.1093/humupd/7.2.161
3. Chan Y.Y., Jayaprakasan K., Zamora J., Thornton J.G., Raine-Fenning N., Coomarasamy A. The prevalence of congenital uterine anomalies in unselected and high-risk populations: a systematic review. Hum Reprod Update. 2011;17(6):761–771. DOI: 10.1093/humupd/dmr028
4. Adamyan L.V., Kulakov V.I., Chaschukoeva A.Z. Malformations of the uterus and vagina. M., Meditsina, 1998;328. (In Russian).
5. Bobkova M.V., Puchko T.K., Adamyan L.V. Reproduction in women with congenital uterus and vagina anomalies. Russian Journal of Human Reproduction. 2018;24(2):42–53. (In Russian). DOI: 10.17116/repro201824242-53
6. Shibelgut N.M., Batina N.A., Еlgina S.I., Mozes V.G., Rudaeva E.V., Zheleznaya A.A. The course of pregnancy and childbirth with abnormal development of the genitals (two-horned uterus). Mother and Baby in Kuzbass. 2022;89(2):56– 61. (In Russian). DOI: 10.24412/2686-7338-2022-2-56-61
7. Chan Y.Y., Jayaprakasan K., Tan A. Reproductive outcomes in women with congenital uterine anomalies: A systematic review. Ultrasound. Obstet. Gynecol. 2011;38(4):371–382. DOI: 10.1002/uog.10056
8. Yoo R.E., Cho J.Y., Kim S.Y., Kim S.H. Magnetic resonance evaluation of Müllerian remnants in Mayer–Rokitansky–Küster-Hauser syndrome. Korean J. Radiol. 2013;14(2):233–239. DOI: 10.3348/kjr.2013.14.2.233
9. Arakelyan A.S., Bychenko V.G., Adamyan L.V., Luzhina I.A., Stepanian A.A. Clinical and diagnostic aspects of the management of patients with malformations of the uterus and vagina: the place and role of magnetic resonance imaging in combination with laparoscopy. Russian Journal of Human Reproduction. 2021;27(4):69–83. (In Russian). DOI: 10.17116/repro20212704169
10. Ulrikh E.A., Urmancheeva A.F. Rare malignant gynecological tumors. St. Petersburg, Eco-Vector, 2022;247. (In Russian).
11. Gao J., Zhang J., Tian W., Teng F., Zhang H., Zhang X., Wang Y., Xue F. Endometrial cancer with congenital uterine anomalies: 3 case reports and a literature review. Cancer Biol. Ther. 2017;18(3):123– 131. DOI: 10.1080/15384047.2017.1281495
12. Chernyshova A.L., Коlomiets L.A., Truschuk Yu.M. Clinical case of endometrial cancer in a patient with complete doubling of the uterus and cervix. Tumors of female reproductive system. 2021;17(2):100–103. (In Russian). DOI: 10.17650/1994-4098-2021-17-2-100-103
13. Colombo N., Preti E., Landoni F., Carinelli S., Colombo A., Marini C. Endometrial cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann. Oncol. 2013; 24(6):i33–38.
14. Amanta F., Mirzab M., Creutzbergc C. FIGO cancer report 2012. Cancer of the corpus uteri. Int. J. Gynecol. Obstet. 2012.119(2):110– 117.
15. Cade T.J., Quinn M.A., McNally O.M. Predictive value of magnetic resonance imaging in assessing myometrial invasion in endometrial cancer: is radiological staging suffi cient for planning conservative treatment? Int. J. Gynecol. Cancer. 2010.20(7):1166–1169.
16. Ortashi O., Jain S., Emannuel O. Evaluation of the sensitivity, specifi city, positive and negative predictive values of preoperative magnetic resonance imaging for staging endometrial cancer. A prospective study of 100 cases at the Dorset Cancer Centre. Eur. J. Obstet. Gynecol. Reprod. Biol. 2008;137(2):232–235.
17. Gavrish Yu.E., Artemieva A.S., Trifanov Yu.N., Nuganen A.O., Sidoruk A.A., Baltrukova A.N., Ulrikh E.A., Berlev I.V., Urmancheeva A.F. Endometrial cancer in patients older than 70 years: clinical and morphological characteristics and long-term results. Voprosy onkologii. 2019;65(3):414–421. (In Russian). DOI:10.37469/0507-3758-2019-65-3
18. Wang H.L., Ren Y.F., Yang J. Total laparoscopic hysterectomy versus total abdominal hysterectomy for endometrial cancer: a metaanalysis. Asian Pac. J. Cancer Prev. 2013;14(4):2515–2519.
19. Colombo N., Creutzberg C., Amant F. ESMO-ESGO-ESTRO Consensus conference on endometrial cancer. Diagnosis, treatment and follow-up. Int. J. Gynecol. Cancer. 2016.26(1):2–30.
Review
For citations:
Zakharov I.S., Schmidt A.A., Borshchevskiy V.G., Solomko D.V., Timoshkova Yu.L., Beskrovniy S.V., Bondareva V.S. Endometrioid carcinoma in a patient with a complete doubling of uterus. Clinical Medicine (Russian Journal). 2023;101(1):68-72. (In Russ.) https://doi.org/10.30629/0023-2149-2023-101-1-68-72
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