Еndovascular embolization as a prevention of recurrent bleeding from the upper gastrointestinal tract
https://doi.org/10.30629/0023-2149-2023-101-1-32-40
Abstract
Goal: to evaluate the results of the use of preventive endovascular hemostasis in patients with a high risk of recurrent bleeding from the upper gastrointestinal tract. Material and methods. The work is based on the study of the results of 158 patients with ulcerative gastroduodenal bleeding and a high risk of its recurrence treatment (17 points or more on the scale of the recurrence of bleeding prediction), Forrest 1–2 A/B and fatal cases (30 points or more on SAPS II). To prevent recurrent bleeding, endovascular embolization of the left gastric or gastroduodenal arteries was performed. Results. The technical success of endovascular hemostasis was achieved in 94.4% of cases (153 patients). In 5 patients, embolization could not be performed due to technical reasons. A complication after transcatheter angiography and embolization was noted in one case (retroperitoneal hematoma that required surgical intervention). Relapse of bleeding after technically successful embolization was noted in 11 (7%) patients. PVA microemboli were used for embolization of the left gastric artery (LVA). Spirals and, in some cases, additional PVA microemboli were used for embolization of the gastroduodenal artery (GDA). The fatal outcome occurred in 26 cases (16.5% of all cases). Conclusion. According to our data, 7% of patients with severe somatic diseases (30 points or more according to SAPS II) and a high risk of bleeding recurrence (17 points or more according to SRBP) occurred in 7% (11 out of all 158 cases).
About the Authors
S. N. PerekhodovRussian Federation
Perekhodov Sergey N.
127473, Moscow
A. V. Snitsar
Russian Federation
Snitsar Artem V
109263, Moscow
N. A. Karpun
Russian Federation
Karpun Nikolai A.
109263, Moscow
D. A. Zelenin
Russian Federation
Zelenin Dmitryi A.
127473, Moscow
S. I. Varfalomeev
Russian Federation
Varfalomeev Stanislav I.
109263, Moscow
References
1. Huang C.S., Lichtenstein D.R. Nonvariceal upper gastrointestinal bleeding. Gastroenterol. Clin. North. Am. 2003;32(4):1053–1078. DOI: 10.1016/s0889-8553(03)00092-x
2. Schoenberg M.H. Surgical therapy for peptic ulcer and nonvariceal bleeding. Langenbecks Arch. Surg. 2001;386(2):98–103. DOI: 10.1007/s004230100210
3. Zatevakhin I.I., Shchegolev A.A., Titkov B.E. Ulcerative gastroduodenal bleeding: the state of the problem and real prospects. Diagnosis and treatment of complicated forms of peptic ulcer of the stomach and duodenum. Collection of scientifi c papers. Smolensk. 2001:32–38. (In Russian).
4. Gostischev V.K., Evseev M.A. Relapse of acute gastroduodenal ulcerative bleeding. Surgery. 2003;7:43–9. (In Russian).
5. Mashkin A.M., Chesnokov E.V., Efanov A.V., Khoyrysh A.A. Results of treatment and prevention of peptic ulcer disease complicated by gastrointestinal bleeding. Surgery in gastroenterology. 2014;6(10):22–25. (In Russian).
6. Aksenov I.V. Emergency operations at the height of ulcerative gastroduodenal bleeding. Materials of the plenum of the Board of the Russian Society of Surgeons «Bleeding from the upper gastrointestinal tract». Voronezh. 2014:7. (In Russian).
7. Hawkey G.M., Cole A.T., McIntyre A.S., Long R.G., Hawkey C.J. Drug treatments in upper gastrointestinal bleeding: value of endoscopic fi ndings as surrogate end points. Gut. 2001 Sep;49(3):372–379. DOI: 10.1136/gut.49.3.372
8. Afendulov S.A., Zhuravlev G.Yu. Surgical treatment of peptic ulcer disease. M., GEOTAR–Media. 2008:333. (In Russian).
9. Blagitko E.M. The main reasons for unsatisfactory treatment results in gastroduodenal bleeding. The Third Congress of surgeons of Siberia and the Far East: materials of the congress. Tomsk. Publishing house «Ivan Fedorov». 2009:7–8. (In Russian)].
10. Zherlov G.K., Koshel A.P., Gibadullin N.V. The choice of surgical tactics for gastroduodenal ulcerative bleeding. Bulletin of Surgery named after I.I. Grekov. 2001;160(2):18–21. (In Russian).
11. Efimenko N.A., Lysenko M.V., Astashov V.A. Bleeding from chronic gastroduodenal ulcers: modern views and treatment prospects. Surgery. 2004 ;3:56– 60. (In Russian)].
12. Ermolov A.S., Karasev N.A., Turko A.P. Emergency surgical care in Moscow for acute diseases of the abdominal cavity. Surgery. 2009;8:4–10. (In Russian)].
13. Cherepanin A.I. Ulcerative gastroduodenal bleeding in patients with high surgical and anesthesiological risk: Dis. Doctor of Medical Sciences. M., 2001:169. (In Russian)].
14. Pantsyrev Yu.M., Mikhalev A.I., Fedorov E.D. Surgical treatment of perforated and bleeding gastro duodenal ulcers. Surgery. 2003;3:43–49. (In Russian)].
15. Defreyne L., De Schrijver I., Decruyenaere J., Van Maele G., Ceelen W., De Looze D., Vanlangenhove P. Therapeutic decisionmaking in endoscopically unmanageable nonvariceal upper gastrointestinal hemorrhage. Cardiovasc. Intervent. Radiol. 2008;31(5):897–905. DOI: 10.1007/s00270-008-9320-x
16. Rösch J., Dotter C.T., Brown M.J. Selective arterial embolization. A new method for control of acute gastrointestinal bleeding. Radiology. 1972;102(2):303–306. DOI: 10.1148/102.2.303
17. Lang E.V., Picus D., Marx M.V., Hicks M.E. Massive arterial hemorrhage from the stomach and lower esophagus: impact of embolotherapy on survival. Radiology. 1990;177(1):249–252. DOI: 10.1148/radiology.177.1.2399325
18. Funaki B. Endovascular intervention for the treatment of acute arterial gastrointestinal hemorrhage. Gastroenterol. Clin. North. Am. 2002;31(3):701–713. DOI: 10.1016/s0889-8553(02)00025-0
19. Holme J.B., Nielsen D.T., Funch-Jensen P., Mortensen F.V. Transcatheter arterial embolization in patients with bleeding duodenal ulcer: an alternative to surgery. Acta Radiol. 2006;47(3):244-247. DOI: 10.1080/02841850600550690
20. Komarov B.D., Losev Yu.A., Uteshev N.S. Application of endovascular methods of diagnosis and stopping acute gastrointestinal bleeding. Bulletin of Surgery named after Grekov. 1977;10:30–35. (In Russian)].
21. Belozerov G.E. X-ray endovascular embolization of arteries in bleeding of various etiologies. Healthcare and medical equipment. 2005;24(10):30–32. (In Russian)].
22. Maksimov A.A. Minimally invasive interventions for bleeding from the upper digestive tract in patients with high operational risk. 2007:136. (In Russian)].
23. Loff roy R., Favelier S., Pottecher P., Estivalet L., Genson P.Y., Gehin S., Cercueil J.P., Krausé D. Transcatheter arterial embolization for acute nonvariceal upper gastrointestinal bleeding: Indications, techniques and outcomes. Diagn. Interv. Imaging. 2015;96(7– 8):731–744. DOI: 10.1016/j.diii.2015.05.002
24. Frisoli J.K., Sze D.Y., Kee S. Transcatheter embolization for the treatment of upper gastrointestinal bleeding. Tech. Vasc. Interv. Radiol. 2004;7(3):136–142. DOI: 10.1053/j.tvir.2005.02.006
25. Kadir S., Lundell C., Saeed M. Celiac, superior, and inferior mesenteric arteries. S.Kadir (Ed.). Atlas of normal and variant angiography anatomy, WB Saunders, Philadelphia. 1991:297–308.
26. Stanulis A.I. Surgical treatment of gastroduodenal bleeding of ulcerative etiology. Surgery. 2001;3:4–7. (In Russian)].
27. Lebedev N.V., Klimov A.E. Prognosis of recurrent bleeding from gastroduodenal ulcers. Surgery. 2009;2:33–37. (In Russian)].
28. Laine L., Jensen D.M. Management of patients with ulcer bleeding. Am. J. Gastroenterol. 2012;107(3):345–360; quiz 361. DOI: 10.1038/ajg.2011.480
29. Lebedev N.V., Klimov A.E. Ulcerative gastroduodenal bleeding. BINOM Publishing House. 2010:176. (In Russian)].
30. Rockall T.A., Logan R.F., Devlin H.B., Northfi eld T.C. Risk assessment after acute upper gastrointestinal haemorrhage. Gut. 1996;38(3):316–321. DOI: 10.1136/gut.38.3.316
31. Masaoka T., Suzuki H., Hori S., Aikawa N., Hibi T. Blatchford scoring system is a useful scoring system for detecting patients with upper gastrointestinal bleeding who do not need endoscopic intervention. J. Gastroenterol. Hepatol. 2007;22(9):1404–1408. DOI: 10.1111/j.1440-1746.2006.04762.x
32. Loff roy R., Rao P., Ota S., De Lin M., Kwak B.K., Geschwind J.F. Embolization of acute nonvariceal upper gastrointestinal hemorrhage resistant to endoscopic treatment: results and predictors of recurrent bleeding. Cardiovasc. Intervent. Radiol. 2010;33(6):1088–1100. DOI: 10.1007/s00270-010-9829-7
33. Sung J.J., Tsoi K.K., Lai L.H., Wu J.C., Lau J.Y. Endoscopic clipping versus injection and thermo-coagulation in the treatment of non-variceal upper gastrointestinal bleeding: a meta-analysis. Gut. 2007;56(10):1364–1373. DOI: 10.1136/gut.2007.123976
34. Parkhomenko I.E. The choice of therapeutic tactics for acute ulcerative gastroduodenal bleeding based on the prediction of its dynamics and outcome. Voronezh. 2007:15. (In Russian)].
35. Loff roy R., Guiu B., Cercueil J.P., Lepage C., Latournerie M., Hillon P., Rat P., Ricolfi F., Krausé D. Refractory bleeding from gastroduodenal ulcers: arterial embolization in high-operative-risk patients. J. Clin. Gastroenterol. 2008;42(4):361–367. DOI: 10.1097/MCG.0b013e3180319177
36. Mirsadraee S., Tirukonda P., Nicholson A., Everett S.M., McPherson S.J. Embolization for non-variceal upper gastrointestinal tract haemorrhage: a systematic review. Clin. Radiol. 2011;66(6):500– 509. DOI: 10.1016/j.crad.2010.11.016
37. Ichiro I., Shushi H., Akihiko I., Yasuhiko I., Yasuyuki Y. Empiric transcatheter arterial embolization for massive bleeding from duodenal ulcers: effi cacy and complications. J. Vasc. Interv. Radiol. 2011;22(7):911–916. DOI: 10.1016/j.jvir.2011.03.001
38. Jensen D.M., Eklund S., Persson T., Ahlbom H., Stuart R., Barkun A.N., Kuipers E.J., Mössner J., Lau J.Y., Sung J.J., Kilhamn J., Lind T. Reassessment of Rebleeding Risk of Forrest IB (Oozing) Peptic Ulcer Bleeding in a Large International Randomized Trial. Am. J. Gastroenterol. 2017;112(3):441–446. DOI: 10.1038/ajg.2016.582
39. Lau J.Y.W., Pittayanon R., Wong K.T., Pinjaroen N., Chiu P.W.Y., Rerknimitr R., Holster I.L., Kuipers E.J., Wu K.C., Au K.W.L., Chan F.K.L., Sung J.J.Y. Prophylactic angiographic embolisation after endoscopic control of bleeding to high-risk peptic ulcers: a randomised controlled trial. Gut. 2019;68(5):796–803. DOI: 10.1136/gutjnl-2018-316074
Review
For citations:
Perekhodov S.N., Snitsar A.V., Karpun N.A., Zelenin D.A., Varfalomeev S.I. Еndovascular embolization as a prevention of recurrent bleeding from the upper gastrointestinal tract. Clinical Medicine (Russian Journal). 2023;101(1):32-40. (In Russ.) https://doi.org/10.30629/0023-2149-2023-101-1-32-40