Сomparative effectiveness of calcium antagonists of prolonged action in patients with stable angina pectoris

Abstract

The article is devoted to investigation the comparative efficacy of therapy with drugs of calcium antagonists with prolong action — dilren and altiasem PP in old patients, suffering from ischemic heart disease, stable stenocardia 2–3 functional class. There were established more efficacy of therapy with dilren then altiasem PP in the relation to clinical symptoms, hemodynamical parameters and their circadian chronostructure. These data manifested by more essential antianginal, antiischemic and vasodilated effects of dilren then of altiasem PP. There were more essential the increase of tolerance to physical loading, promotion of pumping myocardial function under the influence of dilren and tendency to normalization in circadian organization of hemodynamic parameters.