The clinical peculiarities of acute coronary syndrome in patients with oncological disease
https://doi.org/10.30629/0023-2149-2020-98-4-275-281
Abstract
The acute coronary syndrome (ACS) develops in 1.9—4.2% of patients with the diagnosis «an oncological disease» (OD) in different time.
Material and methods. The research included 2 groups of the patients hospitalized with ACS: the main group (n = 88), which had OD in the anamnesis (the period of verif cation of OD<10 years) and the group of comparison (n = 88) created by the «сoру-couple» method on a sex, an age, a structure of ACS. The mean age of patients was 66.6 ± 9.5 years, men prevailed (57.9%), non-ST elevation ACS was at 58% of patients. The level of the statistical signif cantly is р < 0.05.
Results. The most frequent localization of OD: lungs (15.9%), a digestive system (15.9%) and hematologic diseases (14.8%). The patients with ACS and OD, compared with patients with ACS without OD, were signif cantly often with: an atypical anginous attack (15.9% compared with 4.5%, р = 0.025), the main complaint — an asthma or the general weakness (27.3% compared with 14.8%, р = 0.04), the crepitations in lower parts of the lungs (20.5% compared with 9.5%, р = 0.03), an acute left ventricular failure of Killip II—IV (31.8% compared with 15.9%, р = 0.01). The invasive tactics signif cantly was less used in patients with ACS and OD compared with patients with ACS without OD (79.7% compared with 95.5%, р = 0.002). The signif cant differences on defeat of coronary arteries were not revealed. The urgent cardiovascular complications developed more often in patients with ACS and OD compared with patients with ACS without OD (28.2% compared with 6.8%, р = 0.0004), there was higher hospital mortality (12.5% compared with 3.4%, р = 0.048), especially less than 24 hours (7.9% compared with 1.1%, р = 0.03).
Conclusion. The studying of the clinical peculiarities of patients with ACS and OD is necessary for treatment optimization.
About the Authors
M. A. Shalenkova
Clinical Hospital № 38
Russian Federation
Russian Federation
Shalenkova M.A. — MD, PhD, DSc, prof., consultant.
603000, Nizhny Novgorod.
A. V. Ivanov
Clinical Hospital № 38
Russian Federation
Russian Federation
603000, Nizhny Novgorod.
P. F. Klimkin
City Clinical Hospital № 5
Russian Federation
Russian Federation
603005, Nizhny Novgorod.
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Review
For citations:
Shalenkova M.A., Ivanov A.V., Klimkin P.F. The clinical peculiarities of acute coronary syndrome in patients with oncological disease. Clinical Medicine (Russian Journal). 2020;98(4):275-281. (In Russ.) https://doi.org/10.30629/0023-2149-2020-98-4-275-281
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