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Тромбофилия в акушерской практике

https://doi.org/10.30629/0023-2149-2021-99-1-15-20

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Аннотация

Частота тромбоэмболических осложнений, связанных с тромбофилией, очень высока, поэтому обнаружение мутаций тромбофилии в группе пациенток высокого риска важно для профилактики заболеваемости, смертности и акушерских потерь. Проблемой тромбофилии занимаются врачи разных специальностей: лабораторные сотрудники, генетики, сосудистые хирурги, гематологи, неврологи, кардиологи и акушеры-гинекологи. При этом пациенты, имеющие спонтанные тромбозы без видимой причины, наблюдаются годами без должного обследования на тромбофилию. Учитывая, что беременность является состоянием, связанным с высокой вероятностью ретромбозов, целесообразно определять причину и тактику ведения и лечения беременных в максимально ранние сроки беременности.

Об авторах

А. П. Мельников
ГБУЗ МО «Московский областной научно-исследовательский институт акушерства и гинекологии»; Всероссийская ассоциация по изучению тромбозов, геморрагий и патологии сосудов им. А.А. Шмидта–Б.А. Кудряшова
Россия

101000, Москва,

129327, Москва



М. Г. Кащук
ГБУЗ МО «Московский областной научно-исследовательский институт акушерства и гинекологии»
Россия

Кащук Марина Геннадьевна — аспирант

101000, Москва



К. Н. Ахвледиани
ГБУЗ МО «Московский областной научно-исследовательский институт акушерства и гинекологии»
Россия

101000, Москва



И. Н. Бокарев
Всероссийская ассоциация по изучению тромбозов, геморрагий и патологии сосудов им. А.А. Шмидта–Б.А. Кудряшова
Россия

129327, Москва



Список литературы

1. Petrukhin V.A., Melnikov A.P., Budykina T.S., Ratnikov A.O. Possibilities of laboratory control of preventive doses of heparin in obstetric practice. Proceedings of the XXI National Congress with International Participation «Thrombosis, bleeding, and permanent intravascular coagulation» on October 11–13, 2017 in St. Petersburg. 2017;43–44. (in Russian.)

2. Bates S.M., Greer I.A., Middeldorp S. et al. VTE, thrombophilia, antithrombotic therapy, and pregnancy: Antithrombotic therapy and prevention of thrombosis 9th ed. American College of Chest Physicians evidence-based clinical practice guidelines. Chest. 2012; 141:691–736.

3. Grandone E., Tomaiuolo M., Colaizzo D. et al. Role of thrombophilia in adverse obstetric outcomes and their prevention using anti thrombotic therapy. Semin. Thromb. Hemost. 2009;35:630–43.

4. Egeberg O. Inherited antithrombin deficiency causing thrombophilia. Thromb. Diath. Haemorrh. 1965;13:516–30. Cited by I.N. Bokarev «Hematology for a practical doctor». MIA, Moscow. 2018:227. (in Russian.)

5. Franco R.F., Reitsma P.H. Genetic risk factors of venous thrombosis. Hum. Genet. 2001;109:369–84.

6. Schwarz H.P., Fischer M., Hopmeier P., Batard M.A., Griffin J.H. Plasma protein S deficiency in familial thrombotic disease. Blood. 1984;64:1297–1300.

7. Rosendaal F.R. Risk factors for venous thrombotic disease. Thromb. Haemost. 1999;82:610–9.

8. Parand A., Zolghadri J., Nezam M., Afrasiabi A., Haghpanah S., Karimi M. Inherited thrombophilia and recurrent pregnancy loss. Iran Red. Crescent Med. J. 2013;15(12):13708.

9. Folkeringa N., Liindert G., Brouwer P. et al. Redaction of high fetal loss rate by anticoagulant treatment during pregnancy in antitrombin, proyein C or protein S deficint women. Br. J. Haematol. 2017;136:4:656–61.

10. Galli М. Treatment of the antiphospholipid syndrome. Autoimmun. Highlights. 2013;22;5(1):1–7.

11. Castro-Marrero J., Balada E., Vilardell-Tarrés M., Ordi-Ros J. Genetic Risk Factors of Thrombosis in the Antiphospholipid Syndrome. Br. J. Haematol. 2009;147(3):289–96.

12. Miyakis S., Lockshin M., Atusmi T. et al. International consensus statement on an update of the classification criteria for defnite antiphospholipid syndrome (APS). J. Thromb. Haemost. 2006;4: 295–30.

13. James A.H., Tapson V.F., Goldhaber S.Z. Thrombosis during pregnancy and the postpartum period. Am. J. Obstet. Gynecol. 2005;193:216–219.

14. Bertina R.M., Koeleman R.P.C., Koster T. et al. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature. 1994;369:64–67.

15. Ben Salem-Berrabah O., Fekih-Mrissa N., N’siri B., Ben Hamida A., Benammar-Elgaaied A., Gritli N., Mrissa R. Thrombophilic polymorphisms — factor V Leiden G1691A, prothrombin G20210A and MTHFR C677T — in Tunisian patients with cerebral venous thrombosis. J. Clin. Neurosci. 2012;19(9):1326–7.

16. Poort S.R., Rosendaal F.R., Reitsma P.H., Bertina R.M. A common genetic variation in the 3’-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood. 1996;88:3698–3703.

17. Nikitina I.V., Boychuk A.N. The possibilities of predicting miscarriage in multiple pregnancies by evaluating genetic predictors. Journal of the Grodno State Medical University. 2017;1:76. (in Russian.)

18. Monari F., Alberico S., Avagliano L., Cetin I., Cozzolino S., Gargano G., Marozio L., Mecacci F., Neri I., Tranquilli A.L., Venturini P., Facchinetti F. Relation between maternal thrombophilia and stillbirth according to causes/associated conditions of death. Early Hum. Dev. 2012;88(4):251–254.

19. Rosendaal F.R., Doggern C.J., Zivelin A. et al. Geographic distribution of the 20210 G to A prothrombin variant. Thromb. Haemost. 1998;79:706–708.

20. Isaoglu U., Ulug P., Delibas I.B., Yilmaz M., Kumtepe Y., Dogan H., Tasdemir S. The association between inherited thrombophilia and recurrent pregnancy loss in Turkish women. Clin. Exp. Obstet. Gynecol. 2014;41(2):177–181.

21. Hamani N.M. Features of the management of pregnancy and childbirth in a woman with a homozygous prothrombin mutation (Thr165Met) and a history of recurrent pulmonary embolism while taking hormonal contraception. Obstetrics, gynecology and reproduction. 2018;12(1):99–104. (in Russian.)

22. Djordjevic V., Stankovic M., Brankovic-Sreckovic V., Rakicevic L., Damnjanovic T., Antonijevic N., Radojkovic D. Prothrombotic genetic risk factors in stroke: a possible different role in pediatric and adult patients. Clin. Appl. Thromb. Hemost. 2012;18(6):658–661.

23. Nikolaeva M.G., Grigorieva E.E., Serdyuk G.V., Momot A.P. The role of genetic determinants of thrombophilia in the realization of a woman’s reproductive function. Materials of the 10th Anniversary Russian Scientific Forum «Mother and Child». 29.09–02.10.2009 Moscow, 2009:144–145. (in Russian.)

24. Zainullin I.A., Kulavsky V.A., Zainullina A.G., Khustnutdinova E.K. The role of genes of the fi brinolytic system in the occurrence of gestosis. Materials of the 10th Anniversary Russian Scientific Forum «Mother and Child». 29.09–02.10.2009 Moscow, 2009:69. (in Russian.)

25. Ivanov P., Komsa-Penkova R., Ivanov I., Konova E., Kovacheva K., Simeonova M., Tanchev S. Plasminogen activator inhibitor type 1 activity in women with unexplained very early recurrent pregnancy loss. Akush. Ginekol. (Sofiia). 2010;49(5):3–8.

26. Den Heijer M., Lewington S., Clarke R. Homocysteine, MTHFR and risk of venous thrombosis: a meta-analysis of published epidemiological studies. J. Thromb. Haemost. 2005;3:292–299.

27. Key N.S., McGlennen RC. Hyperhomocyst(e)inemia and Throm bophilia. Arch Pathol. Lab. Med. 2002;126(11):1367–1375.

28. Cueto R., Zhang L., Shan H.M., Huang X., Li X., Li Y.F., Lopez J., Yang W.Y., Lavallee M., Yu C., Ji Y., Yang X., Wang H. Identification of homocysteine-suppressive mitochondrial ETC complex genes and tissue expression profile — Novel hypothesis establishment. Redox Biol. 2018;17:70–88.

29. Hakim R.M. Clinical implications of hemodialysis membrane biocompatibility. Kidney Int. 1993;44(3):484–94.

30. Bosch-Marcé M., Pola R., Wecker A.B., Silver M., Weber A., Luedemann C., Curry C., Murayama T., Kearney M., Yoon Y.S., Malinow M.R., Asahara T., Isner J.M., Losordo D.W. Hyper homocyst(e)inemia impairs angiogenesis in a murine model of limb ischemia. Vasc. Med. 2005Feb;10(1):15–22.

31. Gumus E. The powerful association of angiotensin-converting enzyme insertion/deletion polymorphismand idiopathic recurrent pregnancy loss. Ginekol. Pol. 2018;89(10):573–576.

32. Wang Z., Wang P., Wang X., He X., Wang Z., Xu D., Hu J., Wang B. Significant association between angiotensin-converting enzyme gene insertion/deletion polymorphism and risk of recurrent miscarriage: a systematic review and meta-analysis. Metabolism. 2013;62(9): 1227–1238.

33. Nakamura E., Okamoto T., Nagaya K., Hayashi T. Maternal deletion allele of Angiotensin-converting enzyme gene is associated with fetal growth restriction. Pediatr. Dev. Pathol. 2012;15(2):114–7.

34. Chatzidimitriou M., Chatzidimitriou D., Mavridou M., Anetakis C., Chatzopoulou F., Lialiaris T., Mitka S. Thrombophilic gene polymorphisms and recurrent pregnancy loss in Greek women. Int. J. Lab. Hematol. 2017;39(6):590–595.

35. Simioni P. Thrombophilia and gestational VTE. Thrombosis Research. 2009;123(2):41–44.

36. Aggarwal S., Dimri N., Tandon I., Agarwal S. Рreeclampsia in North Indian women: the contribution of genetic polymorphisms. J. Obstet. Gynaecol. Research. 2011; 37(10):1335–1341.


Рецензия

Для цитирования:


Мельников А.П., Кащук М.Г., Ахвледиани К.Н., Бокарев И.Н. Тромбофилия в акушерской практике. Клиническая медицина. 2021;99(1):15-20. https://doi.org/10.30629/0023-2149-2021-99-1-15-20

For citation:


Melnikov A.P., Kashchuk M.G., Ahvlediani K.N., Bokarev I.N. Thrombophilia in obstetric practice. Clinical Medicine (Russian Journal). 2021;99(1):15-20. (In Russ.) https://doi.org/10.30629/0023-2149-2021-99-1-15-20

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ISSN 0023-2149 (Print)
ISSN 2412-1339 (Online)