A view on coronovirus infection based on the Titov’s phylogenetic theory of general pathology
https://doi.org/10.30629/0023-2149-2020-98-9-10-713-718
Abstract
The article is devoted to the creation of the prevention of severe course of COVID-19 molecular model from the standpoint of the Titov’s phylogenetic theory of general pathology. The role of the renin-angiotensin and kallikrein-kinin systems in the severe course of COVID-19 is discussed. Using the example of activation of the renin-angiotensin system in non-communicable diseases, the importance of controlling traditional risk factors for the prevention of severe COVID-19 is shown.
About the Author
Yu. A. Govsha
Tambov Region Clinical Hospital named after Babenko V.D.
Russian Federation
Russian Federation
Yuri A. Govsha — MD, PhD, cardiologist
392000, Tambov
References
1. Titov V.N. Clinical biochemistry: course of lectures; Moscow. INFRA-M, 2017:441. (in Russian)
2. Titov V.N. Phylogenetic theory of general pathology. Pathogenesis of medical pandemics. Arterial hypertension; M. INFRA-M. 2014:212. (in Russian)
3. ТTitov V.N. Diff erence in the phylogenesis of etiological factors and the unity of the pathogenesis of metabolic pandemics. Relative biological «perfection»; Kardiologicheskiy vestnik. 2015;4:56–68. (in Russian)
4. Uingfi ld-Heys R. The mystery of Japan. Why is there a low death rate from Covid-19, despite the risk factors. BBC, Tokyo. July 4, 2020. (in Russian) https://www.bbc.com/russian/news-53291527.
5. Country Profi le: Japan’s experience in combating COVID-19. Department of international and regional cooperation of the Accounts chamber of the Russian Federation.. 17.04.1920. (in Russian)https://ach.gov.ru/upload/pdf/Covid-Japan.pdf.
6. Jia H.P. et al. ACE2 receptor expression and severe acute respiratory syndrome coronavirus infection depend on diff erentiation of human airway epithelia. J. Virol. 2005;79:14614–14621.
7. Hamming I. et al. Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A fi rst step in understanding SARS pathogenesis. J. Pathol. 2004;203:631–637.
8. Protocol for the treatment of COVID-19 of the Medical Center of Moscow State University. (in Russian) http://mc.msu.ru/protokol-mnoc.pdf/.
9. Van de Veerdonk F.; Netea M.G.; van Deuren M.; van der Meer J.W., de Mast Q.; Bruggemann R.J.; van der Hoeven H. Kinins and Cytokines in COVID-19: A Comprehensive Pathophysiological Approach. Preprints 2020, 2020040023. DOI: 10.20944/preprints202004.0023. v1. https://www.preprints.org/manuscript/202004.0023/v1.
10. Yarovaya G.A., Neshkova A.E. Kallikrein-kininin system. Past and present. (To the 90th anniversary of the system opening). Bioorganicheskaya chimia. 2015;3:275–291. (in Russian)
11. Anis Abobaker, Ali Ahmed Rada, Aboubacer Alzwi. Review. Extrapulmonary and atypical clinical presentations of COVID-19. Journal of Medical Virology. 2020;92:2458–2464. https://doi.org/10.1002/jmv.26157.
12. Mareev Yu.V., Mareev V.Yu. The role of age, comorbidities and the activity of the renin-angiotensin-aldesterone system in the manifestations of COVID-19. Eff ects of ACE inhibitors and angiotensin receptor blockers . Kardiologia. 2020;4:4–9. (in Russian)
13. Maggio R., Corsini G.U. Repurposing the mucolytic cough suppressant and TMPRSS2 protease inhibitor bromhexine for the prevention and management of SARS-CoV-2 infection. Pharmacol. Res. 2020;157:104837. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175911/.
14. ТTitov V.N. Inversion of ideas about the biological role of the renin-angiotensin-II-aldesterone system and the function of blood pressure as a regulator of metabolism. Evraziyskiy kardiologicheskiy jurnal. 2015;3:51–61. (in Russian)
15. Lebedev A.A. Renin-angiotensin system. Sorovskiy obrazovatelniy jurnal. 1998;3:35–40. (in Russian)
16. Konkova N.E., Burgal A., Dlin B.B. Modern concepts of the renin-angiotensin system and its role in the regulation of arterial pressure (literature review). Nefrologia i dializ. 2001;2:243–248. (in Russian)
Review
For citations:
A view on coronovirus infection based on the Titov’s phylogenetic theory of general pathology. Clinical Medicine (Russian Journal). 2020;98(9-10):713-718. (In Russ.) https://doi.org/10.30629/0023-2149-2020-98-9-10-713-718
Views:
4202
Email this article 