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Airway remodeling in bronchial asthma: pathogenetic aspects and diagnostic difficulties
https://doi.org/10.30629/0023-2149-2026-104-4-256-263
Abstract
The main reason for the severe and difficult to correct course of asthma is the remodeling of the respiratory tract. The purpose of the review is to summarize the main pathogenetic mechanisms of airway remodeling in asthma and to present the diagnostic capabilities of various methods. Results. The main patterns of development and progression of morphofunctional restructuring of the respiratory tract in asthma are presented. The involvement of immune cells and the role of angiogenesis in the remodeling of the respiratory tract are shown. Instrumental and laboratory diagnostic methods are considered. The diagnosis of airway remodeling faces a number of difficulties. Currently, there are no available non-invasive methods for assessing airway remodeling with high sensitivity and specificity. The lack of informative biomarkers available for airway remodeling limits clinical studies of this process. Understanding the pathogenetic mechanisms, timely diagnosis and treatment of airway remodeling is a promising strategy for preventing the onset and progression of asthma. Conclusion. The pathogenetic mechanisms and modern diagnostic methods of airway remodeling in asthma described and systematized in the review are intended to help in the search for new therapeutic targets for the prediction and treatment of the disease.
About the Authors
E. E. Mineeva
Vladivostok Branch of Far Eastern Scientific Centre of Physiology and Pathology of Respiration — Institute of Medical Climatology and Rehabilitation Treatment
Russian Federation
Russian Federation
Elena E. Mineeva – Candidate of Medical Sciences, Researcher at the Rehabilitation Treatment Laboratory
Vladivostok
M. V. Antonyuk
Vladivostok Branch of Far Eastern Scientific Centre of Physiology and Pathology of Respiration — Institute of Medical Climatology and Rehabilitation Treatment
Russian Federation
Russian Federation
Marina V. Antonyuk – Doctor of Medical Sciences, Professor, Head of the Rehabilitation Treatment Laboratory
Vladivostok
T. A. Gvozdenko
Vladivostok Branch of Far Eastern Scientific Centre of Physiology and Pathology of Respiration — Institute of Medical Climatology and Rehabilitation Treatment
Russian Federation
Russian Federation
Tatiana A. Gvozdenko – Doctor of Medical Sciences, Professor of the Russian Academy of Sciences, Chief Researcher of the Rehabilitation Treatment Laboratory
Vladivostok
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For citations:
Mineeva E.E., Antonyuk M.V., Gvozdenko T.A. Airway remodeling in bronchial asthma: pathogenetic aspects and diagnostic difficulties. Clinical Medicine (Russian Journal). 2026;104(4):256-263. (In Russ.) https://doi.org/10.30629/0023-2149-2026-104-4-256-263
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