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The state of lipid peroxidation and the antioxidant system of the blood in patients with psoriatic arthritis and metabolic syndrome peculiar properties of cytokine status in patients with psoriatic arthritis and metabolic syndrome
L. N. Novikova,
E. V. Dontsova,
A. Yu. Kuranosov,
L. N. Borzunova,
N. I. Ostroushko,
A. A. Bamet'ev,
A. V. Karpishin https://doi.org/10.30629/0023-2149-2026-104-2-117-121
Abstract
The aim of the study: to evaluate the state of the oxidative potential and antioxidant defense system in patients with psoriatic arthritis (PsA) associated with metabolic syndrome (MS).
Material and methods. The study included 278 PsA patients (130 men, 148 women, average age 55.8 ± 6.95 years), of whom 208 had signs of MS, 70 did not. The control group consisted of 45 practically healthy individuals. Enzyme immunoassay was used to determine the total oxidative capacity of blood serum (TOC), total serum antioxidant activity (TAC), blood levels of oxidized LDL (LDL-ox), and superoxide dismutase (SOD).
Results. In patients with PsA and MS, the value of TOC and the level of LDL-ox were 1.3 times higher than in patients without MS, and 1.3 and 2.7 times higher (respectively) than in healthy individuals (p < 0.001). In patients with MS, the blood TAC value and SOD level were significantly lower (1.7 and 2.3 times, respectively) than in patients without MS, and 2.7–3.9 times lower (respectively) relative to its value in the control group (p < 0.001).
Conclusion. In patients with PsA and MS, higher TOC and LDL-ox values were found compared with patients without MS and healthy individuals, along with lower TAC and SOD values.
Supporting agencies: The study had no sponsorship
About the Authors
L. N. Novikova
Voronezh State Medical University
Russian Federation
Russian Federation
Lyubov Anatolyevna Novikova — Doctor of Medical Sciences, Professor, Head of the Department of Dermatovenerology and Cosmetology,
Voronezh
E. V. Dontsova
Voronezh State Medical University
Russian Federation
Russian Federation
Elena Vladimirovna Dontsova — Doctor of Medical Sciences, Associate Professor, Professor of the Department of Dermatovenerology and Cosmetology.
Voronezh
A. Yu. Kuranosov
Voronezh State Medical University
Russian Federation
Russian Federation
Kuranosov Andrey Yurievich — Candidate of Medical Sciences, Assistant of the Department of Faculty therapy.
Voronezh
L. N. Borzunova
Voronezh State Medical University
Russian Federation
Russian Federation
Larisa Nikolaevna Borzunova — Candidate of Medical Sciences, Associate Professor of the Department of Dermatovenereology and Cosmetology.
Voronezh
N. I. Ostroushko
Voronezh State Medical University
Russian Federation
Russian Federation
Ostroushko Nadezhda Igorevna — Candidate of Medical Sciences, Associate Professor of the Department of Healthcare Management.
Voronezh
A. A. Bamet'ev
Voronezh State Medical University
Russian Federation
Russian Federation
Bamet'ev Andrei Alekseevich — Associate Professor of the Department of Dermatovenereology and Cosmetology.
Voronezh
A. V. Karpishin
Voronezh State Medical University
Russian Federation
Russian Federation
Karpishin Aleksey Vladimirovich — physician.
Voronezh
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For citations:
Novikova L.N., Dontsova E.V., Kuranosov A.Yu., Borzunova L.N., Ostroushko N.I., Bamet'ev A.A., Karpishin A.V. The state of lipid peroxidation and the antioxidant system of the blood in patients with psoriatic arthritis and metabolic syndrome peculiar properties of cytokine status in patients with psoriatic arthritis and metabolic syndrome. Clinical Medicine (Russian Journal). 2026;104(2):117-121. (In Russ.) https://doi.org/10.30629/0023-2149-2026-104-2-117-121
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