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Brugada syndrome and COVID-19

https://doi.org/10.30629/0023-2149-2026-104-1-12-16

Abstract

The literature review highlights the relationship between novel coronavirus infection (COVID-19) and Brugada syndrome (SB). The clinical course and treatment tactics of patients with novel coronavirus infection and SB are reviewed and analyzed. When writing the article, we used sources obtained from PubMed and eLibrary.RU - the main sources of biomedical information - to support our research. Discussion. SB is a type of arrhythmia that may not show any clinical symptoms for a long time. It is characterized by specific changes in the electrocardiogram (ECG) and can lead to serious complications such as ventricular fibrillation and sudden cardiac death. The prevalence of this condition is difficult to determine, as it can remain asymptomatic and only be detected through routine ECG testing. The occurrence of SB is associated with a malfunction of the sodium channel, which subsequently leads to dangerous rhythm disturbances. Given the well-known association of COVID–19 with various cardiovascular diseases, including myocarditis and thrombosis, it is important to investigate what effect the new coronavirus infection may have on patients with SB. The growing body of evidence suggests that COVID-19 can trigger or exacerbate the symptoms of SB, making it important to study their interaction. 

About the Authors

N. A. Nikolaev
Omsk State Medical University
Russian Federation

Nikolai A. Nikolaev — Doctor of Medical Sciences, Associate Professor, Head of the Department of Extreme and Evidence-based Medicine 

Omsk 



E. V. Osipenko
Omsk State Medical University
Russian Federation

Elena V. Osipenko — Clinical Resident of the Department of Extreme and Evidence-based Medicine 

Omsk 



D. A. Anishchenko
Omsk State Medical University
Russian Federation

Danil A. Anishchenko — 6th year student of the Pediatric Faculty 

Omsk 



T. I. Gaygiev
Omsk State Medical University
Russian Federation

Tagir I. Gaygiev — Assistant Professor of the Department of Extreme and Evidence-based Medicine 

Omsk 



References

1. Adytia G.J. Brugada Phenocopy vs. Brugada Syndrome: Delineating the Differences for Optimal Diagnosis and Managemen. Current Problems in Cardiology. 2024 ;20(6):102566. DOI: 10.1016/j.cpcardiol.2024.102566. URL: https://www.sciencedirect.com/science/article/pii/S0146280624002056

2. Şahin S. The correlation between brugada syndrome/brugada pattern and fever. Dental and Medical Journal–Review. 2023;5(2):1–11. DOI: 78643/1199973. URL: https://dergipark.org.tr/en/pub/dmj/issue/78643/1199973

3. Zimmermann P. The arrhythmogenic face of COVID-19: Brugada ECG pattern in SARS-CoV-2 infectio. Journal of Cardiovascular Development and Disease. 2022;9(4):96. DOI: 0.3390/jcdd9040096 URL: https://www.mdpi.com/2308–3425/9/4/96

4. Kabra N. Sudden cardiac death in Brugada syndrome. Cardiology in review. 2020;28(4):203–207. DOI: 10.1097/CRD.0000000000000259 URL: https://journals.lww.com/cardiologyinreview/FullText/2020/07000/Sudden_Cardiac_Death_in_Brugada_Syndrome.6.aspx

5. Korlipara H. Brugada syndrome. Acta Cardiologica. 2021;76(8):805– 824. DOI: 10.1080/00015385.2020.1790823 URL: https://www.tandfonline.com/doi/abs/10.1080/00015385.2020.1790823

6. Behr E. R. The genomic architecture of the Brugada syndrome. Heart rhythm. 2021;18(10):1707–1708. DOI: 0.1016/j.hrthm.2021.08.008 URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8572016/

7. Viskin S. Diagnosis of Brugada Syndrome With a Sodium-Channel-Blocker Test: Who Should Be Tested? Who Should Not? Circulation. 2024;150(8):642–650. DOI: 10.1161/circulationaha.124.069138 URL: https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.124.069138

8. Isbister J.C. Brugada syndrome: clinical care amidst pathophysiological uncertainty. Heart, Lung and Circulation. 2020;29(4):538–546. DOI: 10.1016/j.hlc.2019.11.016 URL: https://www.sciencedirect.com/science/article/pii/S1443950619315434

9. Blok M., Boukens B.J. Mechanisms of arrhythmias in the Brugada syndrome. International journal of molecular sciences. 2020;21(19):7051. DOI: 10.3390/ijms21197051 URL: https://www.mdpi.com/1422-0067/21/19/7051

10. Escárcega R.O. The Brugada syndrome. Acta cardiologica. 2009;64(6):795–801. URL: https://www.tandfonline.com/doi/abs/10.2143/AC.64.6.2044745

11. Sorgente A. The known into the unknown: Brugada syndrome and COVID-19. Case Reports. 2020;2(9):1250–1251. DOI: 10.1111/jce.15596. URL: https://www.jacc.org/doi/full/10.1016/j.jaccas.2020.04.006

12. Van De Poll S.W.E. Two patients with COVID-19 and a fever–induced Brugada–like electrocardiographic pattern. Netherlands Heart Journal. 2020;28:431–436. DOI: 10.1007/s12471-020-01459-1 URL: https://link.springer.com/article/10.1007/s12471-020-01459-1

13. Shlyakhto E.V. Features of electrocardiographic changes in non-coronarogenic syndromes in patients with COVID-19. Russian Journal of Cardiology. 2020;5(7):194–200. (In Russ.). DOI: 10.15829/1560-4071-2020-4019 URL: https://cyberleninka.ru/article/n/osobennosti-elektrokardiograficheskih-izmeneniy-pri-nekoronarogennyh-sindromah-u-patsientov-s-covid-19

14. Vinogradova V.V. The effect of COVID-19 on the electrophysiological parameters of the heart. FORCIPE: online edition. 2022;5(3):527–528. (In Russ.). URL: http://ojs3.gpmu.org/index.php/forcipe/article/download/5169/5107

15. Taskina V.Y. Electrocardiographic phenomena in COVID-19: analysis of tele-ECG studies at the Moscow ECG IT Center.Digital Diagnostics: online publication. 2021;2(3):235–248. (In Russ.). URL: https://jdigitaldiagnostics.com/DD/article/download/71885/pdf

16. Mayanskaya S.D. ECG-signs of transient Brugada syndrome in a patient after COVID. Practical medicine. 2023;21(1):91–95. (In Russ.). URL: https://cyberleninka.ru/article/n/ekg–priznaki–tranzitornogo–sindroma–brugada–u–patsienta–posle–covid-19

17. Lawson C.A. Long COVID and cardiovascular disease: a prospective cohort study. Open Heart. 2024;11(1):62. DOI: 1878540922000056URL URL: https://openheart.bmj.com/content/11/1/e002662.abstract

18. Dendramis G. Intensive care and anesthetic management of patients with Brugada syndrome and COVID‐19 infection. Pacing and Clinical Electrophysiology. 2020;43(10):1184–1189. DOI: 10.1111/pace.14044 URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/pace.14044

19. Reyes C.S. COVID-19 fever induced dynamic Brugada electrocardiogram. Romanian Journal of Cardiology. 2022;32(3):165–166. DOI: 10.2478/rjc-2022-0022. URL: https://sciendo.com/article/10.2478/rjc-2022-0022

20. Tomé G., Freitas J. Induced Brugada syndrome: Possible sources of arrhythmogenesis. Revista Portuguesa de Cardiologia. 2017;36(12):945–956. DOI: 10.1016/j.repc.2017.06.015 URL: https://www.sciencedirect.com/science/article/pii/S0870255117300574

21. Honarbakhsh S. A primary prevention clinical risk score model for patients with Brugada syndrome (BRUGADA-RISK). Clinical Electrophysiology. 2021;7(2):210–222. DOI: 10.1016/j.jacep.2020.08.032 URL: https://www.jacc.org/doi/abs/10.1016/j.jacep.2020.08.032

22. Ayad S. Fever and hyponatremia unmasking Brugada pattern electrocardiogram in a patient with SARS-CoV-2 infection. Cureus. 2021; 13(10):180–189. DOI: 10.7759/cureus.18578. URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8572016/

23. Pasquetto G. Syncope, Brugada syndrome, and COVID‐19 lung disease. Journal of arrhythmia. 2020;36(4):768–770. DOI: 10.1002/ joa3.12375 URL: https://onlinelibrary.wiley.com/doi/abs/10.1002/joa3.12375

24. Casella M. Incidence of ventricular arrhythmias related to COVID infection and vaccination in patients with Brugada syndrome: Insights from a large Italian multicenter registry based on continuous rhythm monitoring. Journal of Cardiovascular Electrophysiology. 2023;34(6):1386–1394. DOI: 10.1111/jce.15929. URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/jce.15929

25. Lim K.H. COVID-19 vaccination–induced ventricular fibrillation in an afebrile patient with Brugada syndrome. Journal of Korean Medical Science. 2022;37(42):12–14. DOI: 10.3346/jkms.2022.37.e306 URL: https://synapse.koreamed.org/articles/1516080173

26. Chang D. COVID-19 infection unmasking Brugada syndrome. HeartRhythm Case Reports. 2020;6(5):237–240. URL: https://www. sciencedirect.com/science/article/pii/S2214027120300531

27. Ali S.H. Electrical storm in a patient with Brugada syndrome and coronavirus disease 2019. The Journal of Innovations in Cardiac Rhythm Management. 2022;13(6):5019. DOI: 10.19102/icrm.2022.130601. URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221185/

28. Lemes C.I.S. Brugada pattern unmasked during COVID-19 infection: a case report. Journal of Cardiology Cases. 2022;25(6):377– 380. DOI: 10.1016/j.jccase.2022.01.003 URL: https://www.sciencedirect.com/science/article/pii/S1878540922000056

29. Maglione T.J. Electrical storm in a febrile patient with Brugada syndrome and COVID-19 infection. HeartRhythm Case Reports. 2020;6(10):676–679. DOI: 10.1016/j.hrcr.2020.07.008 URL: https://www.sciencedirect.com/science/article/pii/S2214027120301536

30. Shcherbakova P.A. Brugada syndrome of the second type in a teenage girl with a previously undescribed multisystem inflammatory syndrome associated with SARS-COV-2. The Mechnikov readings. 2021;1:102–103. (In Russ.). URL: https://elibrary.ru/item.asp?id=46398520

31. Suryajaya P.I. Utility of oral quinine sulfate for the treatment of Brugada syndrome presenting as electrical storm in remote areas: resilience in the COVID-19 Era. DOI: 10.1016/j.cjco.2021.09.001. Text: electronic. CJC. 2022;4:105 –108. URL: https://www.academia.edu/download/99729212/pdf.pdf

32. Caturano A. Brugada syndrome and COVID-19 vaccines. EP Europace. 2021:23(12):1871–1872. DOI: 10.1093/europace/ euab211. URL: https://academic.oup.com/europace/article–abstract/23/12/1871/6350068

33. Iyyan M. Brugada pattern induced by Covid-19 infection. Journal of the American College of Cardiology. 2024;83(13):3333–3333. DOI: 10.1080/00015385.2020.1790823 URL: https://www.tandfonline.com/doi/abs/10.1080/00015385.2020.1790823

34. Sookaromdee P. Fever, COVID‐19 vaccination, and Brugada syndrome: Incidence and management-Correspondence. Journal of Cardiovascular Electrophysiology. 2022;33(9):2121. DOI: 10.1111/ jce.15636. URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9539248

35. Cacdac R., Lim A. Type I Brugada pattern in a febrile patient following COVID-19 vaccination booster. Journal of Investigative Medicine High Impact Case Reports. 2024;12:23–24. DOI: 10.1177/23247096231210337 URL: https://journals.sagepub.com/doi/abs/10.1177/23247096231210337

36. Santoro F. Reply to fever, Covid‐19 vaccination, and Brugada syndrome—Incidence and management: Correspondence. Journal of Cardiovascular Electrophysiology. 2022;33(9):2122. DOI: 10.1111/ jce.15636 URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9538316

37. Santoro F. Fever following COVID‐19 vaccination in subjects with Brugada syndrome: incidence and management. Journal of Cardiovascular Electrophysiology. 2022;33(8):1874–1879. URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/jce.15596

38. Okawa K. Unmasked type 1 Brugada ECG pattern without a fever after a COVID-19 vaccination. HeartRhythm Case Reports. 2022;8(4):267–269. DOI: 10.1016/j.hrcr.2022.01.007 URL: https://www.sciencedirect.com/science/article/pii/S1547527121023237

39. Brugada P. Brugada syndrome: various diseases with 1 face. Clinical Electrophysiology. 2023;(9)10:2052–2053. DOI: 10.1016/j.jacep.2023.08.024 URL: https://www.jacc.org/doi/full/10.1016/j. jacep.2023.08.024

40. Nademanee K. Radiofrequency ablation in Brugada syndrome. Heart Rhythm. 2021;18(10):1805–1806. DOI: 10.1016/j.hrthm.2021.08.005 URL: https://www.sciencedirect.com/science/article/pii/S1547527121023237 (аccess date: 12.03.2025).


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For citations:


Nikolaev N.A., Osipenko E.V., Anishchenko D.A., Gaygiev T.I. Brugada syndrome and COVID-19. Clinical Medicine (Russian Journal). 2026;104(1):12-16. (In Russ.) https://doi.org/10.30629/0023-2149-2026-104-1-12-16

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ISSN 0023-2149 (Print)
ISSN 2412-1339 (Online)