clinmedКлиническая медицинаClinical Medicine (Russian Journal)0023-21492412-1339ООО «Медицинское информационное агентство»10.30629/0023-2149-2026-104-1-12-16clinmed-1352Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESСиндром Бругада и COVID-19Brugada syndrome and COVID-19https://orcid.org/0009-0006-6522-420XОсипенкоЕ. В.NikolaevN. A.

Осипенко Елена Витальевна — клинический ординатор кафедры экстремальной и доказательной медицины 

Омск 

Nikolai A. Nikolaev — Doctor of Medical Sciences, Associate Professor, Head of the Department of Extreme and Evidence-based Medicine 

Omsk 

https://orcid.org/0000-0001-8931-7773АнищенкоД. А.OsipenkoE. V.

Анищенко Данил Александрович — студент 6-го курса педиатрического факультета 

Омск 

Elena V. Osipenko — Clinical Resident of the Department of Extreme and Evidence-based Medicine 

Omsk 

dag-0515@mail.ruhttps://orcid.org/0000-0002-1409-7531ГайгиевТ. И.AnishchenkoD. A.

Гайгиев Тагир Ибрагимович — ассистент кафедры экстремальной и доказательной медицины 

Омск 

Danil A. Anishchenko — 6th year student of the Pediatric Faculty 

Omsk 

https://orcid.org/0000-0002-3758-4930НиколаевН. А.GaygievT. I.

Николаев Николай Анатольевич — д-р мед. наук, доцент, заведующий кафедрой экстремальной и доказательной медицины 

Омск 

Tagir I. Gaygiev — Assistant Professor of the Department of Extreme and Evidence-based Medicine 

Omsk 

ФГБОУ ВО «Омский государственный медицинский университет» Минздрава РоссииРоссияOmsk State Medical UniversityRussian Federation20261503202610411216Copyright © Осипенко Е.В., Анищенко Д.А., Гайгиев Т.И., Николаев Н.А., 20262026Осипенко Е.В., Анищенко Д.А., Гайгиев Т.И., Николаев Н.А.Nikolaev N.A., Osipenko E.V., Anishchenko D.A., Gaygiev T.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.clinmedjournal.com/jour/article/view/1352

В обзоре литературы освещена взаимосвязь новой коронавирусной инфекции (COVID-19) и синдрома Бругада (СБ). Рассмотрены и проанализированы клиническое течение и тактика терапии пациентов с новой коронавирусной инфекцией и СБ. При написании статьи были использованы источники, полученные из PubMed и eLIBRARY.RU. Обсуждение. СБ представляет собой один из видов наследственных аритмий, который может долгое время не проявляться клинически. Он проявляется специфическими изменениями на электрокардиограмме (ЭКГ) и может привести к внезапной смерти. Достоверно определить распространенность данного заболевания затруднительно, так как СБ может оставаться бессимптомным и проявляться лишь при рутинной записи ЭКГ. Возникновение СБ связано с нарушением работы натриевого канала, что впоследствии приводит к опасным нарушениям ритма. Учитывая известную ассоциацию COVID-19 с различными сердечно-сосудистыми заболеваниями, включая миокардит и тромбообразование, важно исследовать, какое влияние новая коронавирусная инфекция может оказывать на пациентов с СБ. Накапливающиеся данные указывают на то, что COVID-19 может провоцировать или обострять клинические проявления СБ, что делает актуальным изучение их взаимосвязи. 

The literature review highlights the relationship between novel coronavirus infection (COVID-19) and Brugada syndrome (SB). The clinical course and treatment tactics of patients with novel coronavirus infection and SB are reviewed and analyzed. When writing the article, we used sources obtained from PubMed and eLibrary.RU - the main sources of biomedical information - to support our research. Discussion. SB is a type of arrhythmia that may not show any clinical symptoms for a long time. It is characterized by specific changes in the electrocardiogram (ECG) and can lead to serious complications such as ventricular fibrillation and sudden cardiac death. The prevalence of this condition is difficult to determine, as it can remain asymptomatic and only be detected through routine ECG testing. The occurrence of SB is associated with a malfunction of the sodium channel, which subsequently leads to dangerous rhythm disturbances. Given the well-known association of COVID–19 with various cardiovascular diseases, including myocarditis and thrombosis, it is important to investigate what effect the new coronavirus infection may have on patients with SB. The growing body of evidence suggests that COVID-19 can trigger or exacerbate the symptoms of SB, making it important to study their interaction. 

синдром Бругадафеномен БругадаCOVID-19лихорадкаBrugada syndromeBrugada phenomenonCOVID-19feverReferencesAdytia G.J. Brugada Phenocopy vs. Brugada Syndrome: Delineating the Differences for Optimal Diagnosis and Managemen. Current Problems in Cardiology. 2024 ;20(6):102566. DOI: 10.1016/j.cpcardiol.2024.102566. URL: https://www.sciencedirect.com/science/article/pii/S0146280624002056Adytia G.J. Brugada Phenocopy vs. Brugada Syndrome: Delineating the Differences for Optimal Diagnosis and Managemen. Current Problems in Cardiology. 2024 ;20(6):102566. DOI: 10.1016/j.cpcardiol.2024.102566. URL: https://www.sciencedirect.com/science/article/pii/S0146280624002056Şahin S. The correlation between brugada syndrome/brugada pattern and fever. Dental and Medical Journal–Review. 2023;5(2):1–11. DOI: 78643/1199973. URL: https://dergipark.org.tr/en/pub/dmj/issue/78643/1199973Şahin S. The correlation between brugada syndrome/brugada pattern and fever. Dental and Medical Journal–Review. 2023;5(2):1–11. DOI: 78643/1199973. URL: https://dergipark.org.tr/en/pub/dmj/issue/78643/1199973Zimmermann P. The arrhythmogenic face of COVID-19: Brugada ECG pattern in SARS-CoV-2 infectio. Journal of Cardiovascular Development and Disease. 2022;9(4):96. DOI: 0.3390/jcdd9040096 URL: https://www.mdpi.com/2308–3425/9/4/96Zimmermann P. The arrhythmogenic face of COVID-19: Brugada ECG pattern in SARS-CoV-2 infectio. Journal of Cardiovascular Development and Disease. 2022;9(4):96. DOI: 0.3390/jcdd9040096 URL: https://www.mdpi.com/2308–3425/9/4/96Kabra N. Sudden cardiac death in Brugada syndrome. Cardiology in review. 2020;28(4):203–207. DOI: 10.1097/CRD.0000000000000259 URL: https://journals.lww.com/cardiologyinreview/FullText/2020/07000/Sudden_Cardiac_Death_in_Brugada_Syndrome.6.aspxKabra N. Sudden cardiac death in Brugada syndrome. Cardiology in review. 2020;28(4):203–207. DOI: 10.1097/CRD.0000000000000259 URL: https://journals.lww.com/cardiologyinreview/FullText/2020/07000/Sudden_Cardiac_Death_in_Brugada_Syndrome.6.aspxKorlipara H. Brugada syndrome. Acta Cardiologica. 2021;76(8):805– 824. DOI: 10.1080/00015385.2020.1790823 URL: https://www.tandfonline.com/doi/abs/10.1080/00015385.2020.1790823Korlipara H. Brugada syndrome. Acta Cardiologica. 2021;76(8):805– 824. DOI: 10.1080/00015385.2020.1790823 URL: https://www.tandfonline.com/doi/abs/10.1080/00015385.2020.1790823Behr E. R. The genomic architecture of the Brugada syndrome. Heart rhythm. 2021;18(10):1707–1708. DOI: 0.1016/j.hrthm.2021.08.008 URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8572016/Behr E. R. The genomic architecture of the Brugada syndrome. Heart rhythm. 2021;18(10):1707–1708. DOI: 0.1016/j.hrthm.2021.08.008 URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8572016/Viskin S. Diagnosis of Brugada Syndrome With a Sodium-Channel-Blocker Test: Who Should Be Tested? Who Should Not? Circulation. 2024;150(8):642–650. DOI: 10.1161/circulationaha.124.069138 URL: https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.124.069138Viskin S. Diagnosis of Brugada Syndrome With a Sodium-Channel-Blocker Test: Who Should Be Tested? Who Should Not? Circulation. 2024;150(8):642–650. DOI: 10.1161/circulationaha.124.069138 URL: https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.124.069138Isbister J.C. Brugada syndrome: clinical care amidst pathophysiological uncertainty. Heart, Lung and Circulation. 2020;29(4):538–546. DOI: 10.1016/j.hlc.2019.11.016 URL: https://www.sciencedirect.com/science/article/pii/S1443950619315434Isbister J.C. Brugada syndrome: clinical care amidst pathophysiological uncertainty. Heart, Lung and Circulation. 2020;29(4):538–546. DOI: 10.1016/j.hlc.2019.11.016 URL: https://www.sciencedirect.com/science/article/pii/S1443950619315434Blok M., Boukens B.J. Mechanisms of arrhythmias in the Brugada syndrome. International journal of molecular sciences. 2020;21(19):7051. DOI: 10.3390/ijms21197051 URL: https://www.mdpi.com/1422-0067/21/19/7051Blok M., Boukens B.J. Mechanisms of arrhythmias in the Brugada syndrome. International journal of molecular sciences. 2020;21(19):7051. DOI: 10.3390/ijms21197051 URL: https://www.mdpi.com/1422-0067/21/19/7051Escárcega R.O. The Brugada syndrome. Acta cardiologica. 2009;64(6):795–801. URL: https://www.tandfonline.com/doi/abs/10.2143/AC.64.6.2044745Escárcega R.O. The Brugada syndrome. Acta cardiologica. 2009;64(6):795–801. URL: https://www.tandfonline.com/doi/abs/10.2143/AC.64.6.2044745Sorgente A. The known into the unknown: Brugada syndrome and COVID-19. Case Reports. 2020;2(9):1250–1251. DOI: 10.1111/jce.15596. URL: https://www.jacc.org/doi/full/10.1016/j.jaccas.2020.04.006Sorgente A. The known into the unknown: Brugada syndrome and COVID-19. Case Reports. 2020;2(9):1250–1251. DOI: 10.1111/jce.15596. URL: https://www.jacc.org/doi/full/10.1016/j.jaccas.2020.04.006Van De Poll S.W.E. Two patients with COVID-19 and a fever–induced Brugada–like electrocardiographic pattern. Netherlands Heart Journal. 2020;28:431–436. DOI: 10.1007/s12471-020-01459-1 URL: https://link.springer.com/article/10.1007/s12471-020-01459-1Van De Poll S.W.E. Two patients with COVID-19 and a fever–induced Brugada–like electrocardiographic pattern. Netherlands Heart Journal. 2020;28:431–436. DOI: 10.1007/s12471-020-01459-1 URL: https://link.springer.com/article/10.1007/s12471-020-01459-1Шляхто Е.В. Особенности электрокардиографических изменений при некоронарогенных синдромах у пациентов с COVID-19. Российский кардиологический журнал. 2020;5(7):194–200. DOI: 10.15829/1560-4071-2020-4019 URL: https://cyberleninka.ru/article/n/osobennosti-elektrokardiograficheskih-izmeneniy-pri-nekoronarogennyh-sindromah-u-patsientov-s-covid-19Shlyakhto E.V. Features of electrocardiographic changes in non-coronarogenic syndromes in patients with COVID-19. Russian Journal of Cardiology. 2020;5(7):194–200. (In Russ.). DOI: 10.15829/1560-4071-2020-4019 URL: https://cyberleninka.ru/article/n/osobennosti-elektrokardiograficheskih-izmeneniy-pri-nekoronarogennyh-sindromah-u-patsientov-s-covid-19Виноградова В.В. Влияние перенесенного СOVID-19 на электрофизиологические параметры работы сердца. FORCIPE: сетевое издание. 2022;5(3):527–528. URL: http://ojs3.gpmu.org/index.php/forcipe/article/download/5169/5107Vinogradova V.V. The effect of COVID-19 on the electrophysiological parameters of the heart. FORCIPE: online edition. 2022;5(3):527–528. (In Russ.). URL: http://ojs3.gpmu.org/index.php/forcipe/article/download/5169/5107Таскина В.Ю. Электрокардиографические феномены при COVID-19: анализ теле-ЭКГ-исследований IT-центра ЭКГ г. Москвы. Digital Diagnostics: сетевое издание. 2021;2(3):235– 248. URL: https://jdigitaldiagnostics.com/DD/article/download/71885/pdfTaskina V.Y. Electrocardiographic phenomena in COVID-19: analysis of tele-ECG studies at the Moscow ECG IT Center.Digital Diagnostics: online publication. 2021;2(3):235–248. (In Russ.). URL: https://jdigitaldiagnostics.com/DD/article/download/71885/pdfМаянская С.Д. ЭКГ-признаки транзиторного cиндрома Бругада у пациента после СOVID. Практическая медицина. 2023;21(1): 91–95. URL: https://cyberleninka.ru/article/n/ekg–priznaki–tranzitornogo–sindroma–brugada–u–patsienta–posle–covid-19Mayanskaya S.D. ECG-signs of transient Brugada syndrome in a patient after COVID. Practical medicine. 2023;21(1):91–95. (In Russ.). URL: https://cyberleninka.ru/article/n/ekg–priznaki–tranzitornogo–sindroma–brugada–u–patsienta–posle–covid-19Lawson C.A. Long COVID and cardiovascular disease: a prospective cohort study. Open Heart. 2024;11(1):62. DOI: 1878540922000056URL URL: https://openheart.bmj.com/content/11/1/e002662.abstractLawson C.A. Long COVID and cardiovascular disease: a prospective cohort study. Open Heart. 2024;11(1):62. DOI: 1878540922000056URL URL: https://openheart.bmj.com/content/11/1/e002662.abstractDendramis G. Intensive care and anesthetic management of patients with Brugada syndrome and COVID‐19 infection. Pacing and Clinical Electrophysiology. 2020;43(10):1184–1189. DOI: 10.1111/pace.14044 URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/pace.14044Dendramis G. Intensive care and anesthetic management of patients with Brugada syndrome and COVID‐19 infection. Pacing and Clinical Electrophysiology. 2020;43(10):1184–1189. DOI: 10.1111/pace.14044 URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/pace.14044Reyes C.S. COVID-19 fever induced dynamic Brugada electrocardiogram. Romanian Journal of Cardiology. 2022;32(3):165–166. DOI: 10.2478/rjc-2022-0022. URL: https://sciendo.com/article/10.2478/rjc-2022-0022Reyes C.S. COVID-19 fever induced dynamic Brugada electrocardiogram. Romanian Journal of Cardiology. 2022;32(3):165–166. DOI: 10.2478/rjc-2022-0022. URL: https://sciendo.com/article/10.2478/rjc-2022-0022Tomé G., Freitas J. Induced Brugada syndrome: Possible sources of arrhythmogenesis. Revista Portuguesa de Cardiologia. 2017;36(12):945–956. DOI: 10.1016/j.repc.2017.06.015 URL: https://www.sciencedirect.com/science/article/pii/S0870255117300574Tomé G., Freitas J. Induced Brugada syndrome: Possible sources of arrhythmogenesis. Revista Portuguesa de Cardiologia. 2017;36(12):945–956. DOI: 10.1016/j.repc.2017.06.015 URL: https://www.sciencedirect.com/science/article/pii/S0870255117300574Honarbakhsh S. A primary prevention clinical risk score model for patients with Brugada syndrome (BRUGADA-RISK). Clinical Electrophysiology. 2021;7(2):210–222. DOI: 10.1016/j.jacep.2020.08.032 URL: https://www.jacc.org/doi/abs/10.1016/j.jacep.2020.08.032Honarbakhsh S. A primary prevention clinical risk score model for patients with Brugada syndrome (BRUGADA-RISK). Clinical Electrophysiology. 2021;7(2):210–222. DOI: 10.1016/j.jacep.2020.08.032 URL: https://www.jacc.org/doi/abs/10.1016/j.jacep.2020.08.032Ayad S. Fever and hyponatremia unmasking Brugada pattern electrocardiogram in a patient with SARS-CoV-2 infection. Cureus. 2021; 13(10):180–189. DOI: 10.7759/cureus.18578. URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8572016/Ayad S. Fever and hyponatremia unmasking Brugada pattern electrocardiogram in a patient with SARS-CoV-2 infection. Cureus. 2021; 13(10):180–189. DOI: 10.7759/cureus.18578. URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8572016/Pasquetto G. Syncope, Brugada syndrome, and COVID‐19 lung disease. Journal of arrhythmia. 2020;36(4):768–770. DOI: 10.1002/ joa3.12375 URL: https://onlinelibrary.wiley.com/doi/abs/10.1002/joa3.12375Pasquetto G. Syncope, Brugada syndrome, and COVID‐19 lung disease. Journal of arrhythmia. 2020;36(4):768–770. DOI: 10.1002/ joa3.12375 URL: https://onlinelibrary.wiley.com/doi/abs/10.1002/joa3.12375Casella M. Incidence of ventricular arrhythmias related to COVID infection and vaccination in patients with Brugada syndrome: Insights from a large Italian multicenter registry based on continuous rhythm monitoring. Journal of Cardiovascular Electrophysiology. 2023;34(6):1386–1394. DOI: 10.1111/jce.15929. URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/jce.15929Casella M. Incidence of ventricular arrhythmias related to COVID infection and vaccination in patients with Brugada syndrome: Insights from a large Italian multicenter registry based on continuous rhythm monitoring. Journal of Cardiovascular Electrophysiology. 2023;34(6):1386–1394. DOI: 10.1111/jce.15929. URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/jce.15929Lim K.H. COVID-19 vaccination–induced ventricular fibrillation in an afebrile patient with Brugada syndrome. Journal of Korean Medical Science. 2022;37(42):12–14. DOI: 10.3346/jkms.2022.37.e306 URL: https://synapse.koreamed.org/articles/1516080173Lim K.H. COVID-19 vaccination–induced ventricular fibrillation in an afebrile patient with Brugada syndrome. Journal of Korean Medical Science. 2022;37(42):12–14. DOI: 10.3346/jkms.2022.37.e306 URL: https://synapse.koreamed.org/articles/1516080173Chang D. COVID-19 infection unmasking Brugada syndrome. HeartRhythm Case Reports. 2020;6(5):237–240. URL: https://www.sciencedirect.com/science/article/pii/S2214027120300531Chang D. COVID-19 infection unmasking Brugada syndrome. HeartRhythm Case Reports. 2020;6(5):237–240. URL: https://www. sciencedirect.com/science/article/pii/S2214027120300531Ali S.H. Electrical storm in a patient with Brugada syndrome and coronavirus disease 2019. The Journal of Innovations in Cardiac Rhythm Management. 2022;13(6):5019. DOI: 10.19102/icrm.2022.130601. URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221185/Ali S.H. Electrical storm in a patient with Brugada syndrome and coronavirus disease 2019. The Journal of Innovations in Cardiac Rhythm Management. 2022;13(6):5019. DOI: 10.19102/icrm.2022.130601. URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221185/Lemes C.I.S. Brugada pattern unmasked during COVID-19 infection: a case report. Journal of Cardiology Cases. 2022;25(6):377– 380. DOI: 10.1016/j.jccase.2022.01.003 URL: https://www.sciencedirect.com/science/article/pii/S1878540922000056Lemes C.I.S. Brugada pattern unmasked during COVID-19 infection: a case report. Journal of Cardiology Cases. 2022;25(6):377– 380. DOI: 10.1016/j.jccase.2022.01.003 URL: https://www.sciencedirect.com/science/article/pii/S1878540922000056Maglione T.J. Electrical storm in a febrile patient with Brugada syndrome and COVID-19 infection. HeartRhythm Case Reports. 2020;6(10):676–679. DOI: 10.1016/j.hrcr.2020.07.008 URL: https://www.sciencedirect.com/science/article/pii/S2214027120301536Maglione T.J. Electrical storm in a febrile patient with Brugada syndrome and COVID-19 infection. HeartRhythm Case Reports. 2020;6(10):676–679. DOI: 10.1016/j.hrcr.2020.07.008 URL: https://www.sciencedirect.com/science/article/pii/S2214027120301536Щербакова П.А. Синдром Бругада второго типа у девочки– подростка с ранее не описанным мультисистемным воспалительным синдромом, ассоциированным с SARS-CoV-2. Мечниковские чтения. 2021;1:102–103. URL: https://elibrary.ru/item.asp?id=46398520Shcherbakova P.A. Brugada syndrome of the second type in a teenage girl with a previously undescribed multisystem inflammatory syndrome associated with SARS-COV-2. The Mechnikov readings. 2021;1:102–103. (In Russ.). URL: https://elibrary.ru/item.asp?id=46398520Suryajaya P.I. Utility of oral quinine sulfate for the treatment of Brugada syndrome presenting as electrical storm in remote areas: resilience in the COVID-19 Era. DOI: 10.1016/j.cjco.2021.09.001. Text: electronic. CJC. 2022;4:105 –108. URL: https://www.academia.edu/download/99729212/pdf.pdfSuryajaya P.I. Utility of oral quinine sulfate for the treatment of Brugada syndrome presenting as electrical storm in remote areas: resilience in the COVID-19 Era. DOI: 10.1016/j.cjco.2021.09.001. Text: electronic. CJC. 2022;4:105 –108. URL: https://www.academia.edu/download/99729212/pdf.pdfCaturano A. Brugada syndrome and COVID-19 vaccines. EP Europace. 2021:23(12):1871–1872. DOI: 10.1093/europace/ euab211. URL: https://academic.oup.com/europace/article–abstract/23/12/1871/6350068Caturano A. Brugada syndrome and COVID-19 vaccines. EP Europace. 2021:23(12):1871–1872. DOI: 10.1093/europace/ euab211. URL: https://academic.oup.com/europace/article–abstract/23/12/1871/6350068Iyyan M. Brugada pattern induced by Covid-19 infection. Journal of the American College of Cardiology. 2024;83(13):3333–3333. DOI: 10.1080/00015385.2020.1790823 URL: https://www.tandfonline.com/doi/abs/10.1080/00015385.2020.1790823Iyyan M. Brugada pattern induced by Covid-19 infection. Journal of the American College of Cardiology. 2024;83(13):3333–3333. DOI: 10.1080/00015385.2020.1790823 URL: https://www.tandfonline.com/doi/abs/10.1080/00015385.2020.1790823Sookaromdee P. Fever, COVID‐19 vaccination, and Brugada syndrome: Incidence and management-Correspondence. Journal of Cardiovascular Electrophysiology. 2022;33(9):2121. DOI: 10.1111/ jce.15636. URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9539248Sookaromdee P. Fever, COVID‐19 vaccination, and Brugada syndrome: Incidence and management-Correspondence. Journal of Cardiovascular Electrophysiology. 2022;33(9):2121. DOI: 10.1111/ jce.15636. URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9539248Cacdac R., Lim A. Type I Brugada pattern in a febrile patient following COVID-19 vaccination booster. Journal of Investigative Medicine High Impact Case Reports. 2024;12:23–24. DOI: 10.1177/23247096231210337 URL: https://journals.sagepub.com/doi/abs/10.1177/23247096231210337Cacdac R., Lim A. Type I Brugada pattern in a febrile patient following COVID-19 vaccination booster. Journal of Investigative Medicine High Impact Case Reports. 2024;12:23–24. DOI: 10.1177/23247096231210337 URL: https://journals.sagepub.com/doi/abs/10.1177/23247096231210337Santoro F. Reply to fever, Covid‐19 vaccination, and Brugada syndrome—Incidence and management: Correspondence. Journal of Cardiovascular Electrophysiology. 2022;33(9):2122. DOI: 10.1111/jce.15636 URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9538316Santoro F. Reply to fever, Covid‐19 vaccination, and Brugada syndrome—Incidence and management: Correspondence. Journal of Cardiovascular Electrophysiology. 2022;33(9):2122. DOI: 10.1111/ jce.15636 URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9538316Santoro F. Fever following COVID‐19 vaccination in subjects with Brugada syndrome: incidence and management. Journal of Cardiovascular Electrophysiology. 2022;33(8):1874–1879. URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/jce.15596Santoro F. Fever following COVID‐19 vaccination in subjects with Brugada syndrome: incidence and management. Journal of Cardiovascular Electrophysiology. 2022;33(8):1874–1879. URL: https://onlinelibrary.wiley.com/doi/abs/10.1111/jce.15596Okawa K. Unmasked type 1 Brugada ECG pattern without a fever after a COVID-19 vaccination. HeartRhythm Case Reports. 2022;8(4):267–269. DOI: 10.1016/j.hrcr.2022.01.007 URL: https://www.sciencedirect.com/science/article/pii/S1547527121023237Okawa K. Unmasked type 1 Brugada ECG pattern without a fever after a COVID-19 vaccination. HeartRhythm Case Reports. 2022;8(4):267–269. DOI: 10.1016/j.hrcr.2022.01.007 URL: https://www.sciencedirect.com/science/article/pii/S1547527121023237Brugada P. Brugada syndrome: various diseases with 1 face. Clinical Electrophysiology. 2023;(9)10:2052–2053. DOI: 10.1016/j.jacep.2023.08.024 URL: https://www.jacc.org/doi/full/10.1016/j.jacep.2023.08.024Brugada P. Brugada syndrome: various diseases with 1 face. Clinical Electrophysiology. 2023;(9)10:2052–2053. DOI: 10.1016/j.jacep.2023.08.024 URL: https://www.jacc.org/doi/full/10.1016/j. jacep.2023.08.024Nademanee K. Radiofrequency ablation in Brugada syndrome. Heart Rhythm. 2021;18(10):1805–1806. DOI: 10.1016/j.hrthm.2021.08.005 URL: https://www.sciencedirect.com/science/article/pii/S1547527121023237 (аccess date: 12.03.2025).Nademanee K. Radiofrequency ablation in Brugada syndrome. Heart Rhythm. 2021;18(10):1805–1806. DOI: 10.1016/j.hrthm.2021.08.005 URL: https://www.sciencedirect.com/science/article/pii/S1547527121023237 (аccess date: 12.03.2025).

The authors declare that there are no conflicts of interest present.