Changes in the level of serum markers of liver fibrosis in patients with a combined form of chronic hepatitis C and herpes infection

Purpose of the study. To evaluate the severity of liver fibrosis, the level of serum markers of fibrosis and their prognostic value in HCV patients and patients with mixed infection (HCV and herpes infection). Material and methods. The article presents the results of the study of changes in the level of serum markers of liver fibrosis in patients with mono-infection with HCV genotypes 1, 2, 3 and mix-infection HCV and herpes co-infection in three stages of the study in dynamics during treatment with antiviral drugs and their prognostic possibilities. A number of important biochemical parameters were evaluated state of liver morphology and function: ALT, AST, GGT, cholinesterase, alkaline phosphatase, total protein, total bilirubin and blood glucose. In both study groups at the stages of observation all biochemistry indices after treatment were registered within the limits of normal values. The study was conducted in the laboratory of the State Budgetary Institution of the Russian Center for AIDS and IZ of the Republic of Bashkortostan, Ufa, where 46 people with HCV participated, two study groups: with mono-infection with CHC and with mix-infection (HCV and herpes infection — HPV-1, VEB, CMV). Results and discussion. According to the data of the study in group 1 of patients with HCV with expressed fibrosis and cirrhosis of the liver all biochemical indices after antiviral therapy were set within the limits of normal values, in group 2 of patients with mix-infection and expressed fibrosis and cirrhosis after antiviral and specific anti-herpetic therapy a part of indices — total protein, total bilirubin, alkaline phosphate, CE, GGT, blood glucose — tended to normalization, ALT and AST indices did not come to normal. Correlation analysis of indices of fibrosis stage by indirect elastometry method revealed a reliable relationship with the values of indirect markers of liver fibrosis, the degree of thrombocytopenia. Conclusions. In patients with mix-infection (HCV and herpetic infection) with identical course of HCV, more pronounced inflammatory and fibrotic processes in liver tissue, more rapid rates of fibrosis prevailed compared to patients with mono-infection with HCV, which is reflected in fibroеlastometry data and indices of indirect markers of liver fibrosis (biochemical indices), as quite informative and available in clinical practice.

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