Use of diffusion-weighted magnetic resonance imaging in patients with lymphoproliferative diseases during primary staging

The article presents data on the diagnostic accuracy of the DWI MRI method in the initial assessment of the prevalence of lymphomas. The study included 81 patients with different types of lymphomas. DV MRI was performed in all patients before the start of therapy and after the initial PET/CT examination. As a result of the work performed, the diagnostic accuracy is 91.31%, sensitivity — 93.48%, specificity — 88.32%, positive predictive value — 91.48%, negative predictive value — 90.91%, positive likelihood ratio 7.95, negative likelihood ratio 0.74. The area of the ROC curve was 0.9481. The most accurate results were found in patients with stages 1 and 2 of the disease. The data obtained indicate the high diagnostic value of the DWI MRI method in the primary assessment of the prevalence of the disease. At the same time, there are cases confirming, unfortunately, the limitation of the diagnostic capabilities of the method when assessing groups of lymph nodes located near the heart region, or when assessing the objective involvement of the bone marrow in the pathological process, which in turn may affect the primary the staging of the process and, consequently, the choice of therapy regimen, which directly affects the outcome of the disease. Based on the analysis, it can be concluded that the PET/CT method is the best for detecting tumor lesions in patients with lymphomas, at the same time, the DWI MRI method can be used to assess the prevalence of the disease in the absence of the possibility of using PET/CT scan with FDG.

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