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Effect of thymalin on adaptive immunity in complex therapy for patients with COVID-19

https://doi.org/10.30629/0023-2149-2020-98-8-593-599

Abstract

Results of comparative assessment of level of antibodies of IgG to SARS-CoV-2 in dynamics at standard and complex methods of treatment with use of medicinal peptide medicine of a timus of a timalin for patients with COVID-19 are presented in article. It was found that as a result of standard treatment, patients showed a decrease in antibody levels by 53% after 104 days. The addition of thymalin to standard therapy slowed down the decline of this indicator. So, a similar indicator in patients who took thymalin was only 21%. This contributed to maintaining strained adaptive immunity. The detected immunomodulatory properties of the preparation of thymalin with respect to COVID-19 can be reflected both in the formation of an effective immune layer of the population through natural immunization, and in the process of antibody formation during vaccination of target contingents.

About the Authors

V. Kh. Khavinson
Saint Petersburg Institute of Bioregulation and Gerontology; I.P. Pavlov Institute of Physiology of the Russian Academy of Sciences
Russian Federation

Vladimir Kh. Khavinson — MD. PhD, DSc, prof., corresponding member of the Russian Academy of Sciences, director Saint Petersburg Institute of Bioregulation and Gerontology

197110, Saint Petersburg

199034, Saint Petersburg



B. I. Kuznik
Chita State Medical Academy
Russian Federation
672000, Chita


V. A. Volchkov
Saint Petersburg City Multiprofile Hhospital №2
Russian Federation
194354, Saint Petersburg


S. A. Rukavishnikova
Saint Petersburg City Multiprofile Hhospital №2; Saint Petersburg State I.P. Pavlov Medical University
Russian Federation

194354, Saint Petersburg

197022, Saint Petersburg



O. N. Titova
Saint Petersburg State I.P. Pavlov Medical University
Russian Federation
197022, Saint Petersburg


T. A. Akhmedov
Saint Petersburg City Multiprofile Hhospital №2; Saint Petersburg State I.P. Pavlov Medical University
Russian Federation

194354, Saint Petersburg

197022, Saint Petersburg



S. V. Trofimova
Saint Petersburg Institute of Bioregulation and Gerontology
Russian Federation
197110, Saint Petersburg


G. A. Ryzhak
Saint Petersburg Institute of Bioregulation and Gerontology
Russian Federation
197110, Saint Petersburg


V. V. Potyomkin
Saint Petersburg City Multiprofile Hhospital №2; Saint Petersburg State I.P. Pavlov Medical University
Russian Federation

194354, Saint Petersburg

197022, Saint Petersburg



U. R. Saginbaev
Saint Petersburg State I.P. Pavlov Medical University
Russian Federation
197022, Saint Petersburg


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Review

For citations:


Khavinson V.Kh., Kuznik B.I., Volchkov V.A., Rukavishnikova S.A., Titova O.N., Akhmedov T.A., Trofimova S.V., Ryzhak G.A., Potyomkin V.V., Saginbaev U.R. Effect of thymalin on adaptive immunity in complex therapy for patients with COVID-19. Clinical Medicine (Russian Journal). 2020;98(8):593-599. (In Russ.) https://doi.org/10.30629/0023-2149-2020-98-8-593-599

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ISSN 0023-2149 (Print)
ISSN 2412-1339 (Online)