Generate QR code
Open Access
Subscription Access
Titanium-containing medicinal products in medicine on the example of an aqua complex of titanium glycerosolvate
https://doi.org/10.30629/0023-2149-2025-103-7-506-512
Abstract
The article discusses the issue of the use of combined titanium-containing drugs in practical medicine using the example of an aquacomplex of titanium glycerosolvate (AGT). The purpose of this work was to analyze the effectiveness of the use of titanium-containing drugs in various fields of medicine. The materials for the study were the official information base of Roszdravnadzor “State Register of Medicines”, legal information bases “Consultant”, “Garant” (accessed 11/25/2024), scientific journal articles from the database Elibrary, PubMed and RusMed. Articles containing isolated observations and having poor statistical processing were excluded from the review. The unique properties of the AGT are described in detail, allowing it to be widely used in surgery, dentistry, dermatology, rheumatology, traumatology, pediatrics and other fields. Its safety is emphasized. The nosological units of its application in various fields of medical practice are given. Combinations of AGT with various medicines used in practical healthcare are described in detail. The study demonstrated the advantages of using an AGT with different drugs compared with its isolated use due to potentiation and prolongation of their action. It is emphasized that this titanium preparation can serve as an ointment base for the development of combined medicines.
About the Authors
E. G. Feoktistova
Penza State University
Russian Federation
Russian Federation
Elena G. Feoktistova — Candidate of Medical Sciences, Associate Professor of the Department of Surgery
Penza
A. A. Emelyanov
OOO “Olympus”
Russian Federation
Russian Federation
Alexander A. Emelyanov — General Director
Yekaterinburg
A. A. Andreev
Voronezh State Medical University named after N.N. Burdenko
Russian Federation
Russian Federation
Alexander A Andreev — Doctor of Medical Sciences, Professor of the Department of General and Outpatient Surgery
Voronezh
A. A. Glukhov
Voronezh State Medical University named after N.N. Burdenko
Russian Federation
Russian Federation
Alexander A. Glukhov — Doctor of Medical Sciences, Professor, Head of the Department of General and Outpatient Surgery
Voronezh
T. G. Nikishina
Voronezh State Medical University named after N.N. Burdenko
Russian Federation
Russian Federation
Tatyana G. Nikishina — Candidate of Medical Sciences, Associate Professor of the Department of General and Outpatient Surgery
Voronezh
References
1. Gammel I.V., Zhukova O.V., Kononova S.V., Konnova M.A. Study of the range of drugs in the dosage form of ointment. Issues of biological, medical and pharmaceutical chemistry. 2019;22(8):3−9. (In Russian). DOI: 10.29296/25877313-2019-08-01
2. Emelyanov A.A., Makhotina M.V., Petrov A.Yu., Smagina T.A. Titanium glycerosolvate aquacomplex (Tizol®) – an original base (excipient) for obtaining medicines. In the collection: Collection of articles of the XIII All-Russian scientific and practical conference “Results of modern scientific research and development”. Penza. 2021:220–225. (In Russian).
3. Povoroznyuk V.V., Orlik T.V., Kozitskaya S.V. Innovative drug “Gialgel” for the treatment of patients with osteoarthrosis of joints of II-III degree. Polyclinic. 2016;1(1):72–73. (In Russian).
4. Tsap N.A., Rubtsov V.V., Ognev S.I. Active components of anti-adhesive therapy based on titanium nanoparticles. Medical almanac. 2019;5–6(61):46–50. (In Russian). DOI: 10.21145/2499-9954-2019-5-46-50
5. Kryuchkova N.A., Temkin E.S., Sysuev B.B. Efficiency of using a combination of mineral-containing drugs in the treatment of inflammatory periodontal diseases. Symbol of Science: international scientific journal. 2016;12–3(24):154–157. (In Russian).
6. Gulova N.V., Andreev A.A. Use of titanium glycerosolvate aquacomplex in the treatment of experimental osteomyelitis. Youth Innovation Bulletin. 2019;8(2):9–10. (In Russian).
7. Povoroznyuk V.V., Orlik T.V., Kozitskaya S.V. Innovative drug “Gialgel” for the treatment of patients with grade II-III joint osteoarthritis. Polyclinic. 2016;1(1):72–73. (In Russian).
8. Popova M.I., Kobeleva T.A., Sichko A.I. Spectrophotometric study of carvedilol in a drug prepared on a titanium glycerosolvate aqua complex. Postgraduate Bulletin of the Volga Region. 2022;22(2):67–72. (In Russian). DOI: 10.55531/2072-2354.2022.22.2.67-72
9. Ron G.I., Akmalova G.M. Increasing the effectiveness of local treatment for lichen planus of the oral mucosa. Kazan Medical Journal. 2014;95(3):338–340. (In Russian).
10. Grebnev D.Yu. Effect of titanium glycerosolvate aqua complex on apoptosis and mutagenic activity of jejunal epithelial cells under conditions of exposure to ionizing radiation. In the collection: Pharmacy and public health. Proceedings of the annual conference: collection of articles. Ekaterinburg. 2009:83–85. (In Russian).
11. Anisimova T.G. Theoretical aspects of the creation and pharmaceutical analysis of combinations of antifungal and anti-inflammatory ointments with Tizol gel. Issues of biological, medical and pharmaceutical chemistry. 2021;24(8):49–55. (In Russian). DOI: 10.29296/25877313-2021-08-07
12. Solovieva A.G., Peretyagin S.P., Zimin Yu.V., Martusevich A.K., Larionova K.D. Effect of medicinal compositions with transcutaneous activity on metabolic adaptation of the liver in experimental burn injury. Fundamental research. 2012;10(1):116–121. (In Russian).
13. Makhotina M.V., Emelyanova I.V., Petrov A.Yu., Melnikova O.A. Study of complexing properties of the base of Tizol gel. Scientific Bulletin of Belgorod State University. Series: Medicine. Pharmacy. 2017;12(261):112–119. (In Russian).
14. Zamaraeva A.I., Kobeleva T.A., Sichko A.I., Bessonova N.S. Study of physicochemical parameters of new ointments with some chemotherapeutic drugs. Internauka. 2022;9,1(232):28–32. (In Russian).
15. Yachmeneva E.S., Sonina O.A. Efficiency of using Tizol with vitamin E in cosmetic rehabilitation of patients after aesthetic surgeries. New technologies in medicine and pharmacy. Tizol: Collection of scientific articles. Materials of the interregional scientific and practical conference / Ed. O.P. Kovtun. - Ekaterinburg, State Educational Institution of Higher Professional Education Roszdrav. 2010:82–90. (In Russian).
16. Yachmeneva E.S., Sonina O.A. Efficiency of using Tizol with vitamin E in cosmetic rehabilitation of patients after aesthetic surgeries. New technologies in medicine and pharmacy. Tizol: Collection of scientific articles. Materials of the interregional scientific and practical conference / Ed. O.P. Kovtun. — Ekaterinburg, State Educational Institution of Higher Professional Education Roszdrav. 2010:153–157. (In Russian).
17. Balabanova R.M., Fedina T.P. Experience of using Tizol gel for local therapy of rheumatoid arthritis. Scientific and practical rheumatology. 2004;3:37–39. (In Russian).
18. Pigareva A.E., Tsap N.A. Modern strategy of diagnostics and local treatment of chronic cystitis in children. Ural Medical Journal. 2012;95(3):107–111. (In Russian).
19. Larionova K.D. Pathogenetic substantiation of local application of medicinal compositions with high transcutaneous activity in treatment of burn wounds: specialty 14.03.03. “Pathological physiology”; 14.01.15 “Traumatology and orthopedics”: dissertation for the degree of candidate of medical sciences / Larionova Ksenia Danilovna; Federal State Budgetary Institution “Nizhny Novgorod Research Institute of Traumatology and Orthopedics. Nizhny Novgorod, 2014:158. (In Russian).
20. Evseev V.A., Milutina E.Yu., Khobotov A.V., Milyutin N.V. Experience with the use of hydrophilic gel Tizol with lidase in the treatment of the consequences of thermal injuries. Scientific journal “Internauka”. 2023;5(275):47–48. (In Russian).
21. Tsap N.A., Borisov S.A., Glinskikh O.V. Antiangiogenic therapy of cavernous hemangiomas in infants. Russian Pediatric Journal. 2023;26(S3):63. (In Russian).
22. Mokhova O.S., Glukhov A.A. Clinical evaluation of the effectiveness of oxytocin and titanium glycerosolvate aqua complex in the complex treatment of soft tissue wounds. Bulletin of New Medical Technologies. Electronic publication. 2013;1:182. (In Russian).
23. Brazhnik E.A., Glukhov A.A., Aralova M.V. Use of Derinat and titanium glycerosolvate aquacomplex in the treatment of destructive forms of erysipelas. Bulletin of Surgery. 2017;176(6):71–75. (In Russian).
24. Saidgalin G.Z., Shtukaturov A.K., Salisty P.V., Markovskaya O.V., Gritsenko D.A., Lukin O.V., Emelianov A.S. Patent No. 2209074 Russian Federation, IPC A61K 35/14 (2000.01), A61K 47/10 (2000.01), A61K 9/06 (2000.01). Composition for the treatment of burns: No. 2001124020/14: declared 29.08.2001: published 27.07.2003. (In Russian).
25. Sokolova L.A. Tizol and its use in local therapy of rheumatoid arthritis. Scientific and practical rheumatology. Moscow. 2002;3:39–41. (In Russian).
26. Kozlov V.A., Vorobyov S.A., Rubinov M.A., Sorokina E.E., Levchik E.Yu., Vlasov A.A. Composition of Tizol with 3% metallic iodine in local treatment of trophic lesions in chronic arterial ischemia of the lower extremities. Highly effective technologies in medicine Tizol: Collection of materials of the interregional scientific and practical conference. Responsible editor V.I. Shilko. Ekaterinburg, UGMA. 2001:56–58. (In Russian).
27. Gagin P.A., Beketov B.N. Development of methods for analysis and evaluation of the bioavailability of an ointment based on Tizol. Medical Science and Education of the Urals. 2012;13,3,1(71):57–59. (In Russian)].
28. Mokhova O.S., Glukhov A.A. Features of the course of the wound process with regional use of an aqua complex of titanium glycerosolvate and oxytocin in an experiment. Bulletin of Experimental and Clinical Surgery. 2014;7(4):419–423. (In Russian).
29. Novomlinsky V.V. Application of laser technologies and titanium glycerosolvate aqua complex in the treatment of chronic osteomyelitis. Bulletin of Experimental and Clinical Surgery. 2016;9(2):156–164. (In Russian). DOI: 10.18499/2070-478X-2016-9-2-156-164
30. Andreev A.A., Novomlinsky V.V., Mikulich E.V., Malkina N.A. Oxidative stress indicators in the treatment of experimental chronic osteomyelitis using titanium glycerosolvate aqua complex and laser technologies. In the collection: peritonitis from A to Z (All-Russian school). Proceedings of the IX All-Russian Conference of General Surgeons with International Participation. Edited by A.B. Larichev. 2016:633–636. (In Russian).
31. Gulova N.V., Andreev A.A. Use of titanium glycerosolvate aquacomplex in the treatment of experimental osteomyelitis. Youth Innovation Bulletin. 2019;8(2):9–10. (In Russian).
32. Vinnichenko M.M., Tsap N.A. Model of peritonitis and experimental substantiation of anti-adhesive therapy. Bulletin of Experimental and Clinical Surgery. 2014;7(4):373–377. (In Russian).
33. Bagishev R.A., Krivigina E.V., Zhigaev G.F. Efficiency of the drug “Tizol” in colitis of disconnected sections of the colon. Coloproctology. 2014;1(47):3– 8. (In Russian).
34. Salisty P.V., Saidgalin G.Z., Biktashev V.S., Faizyanov A.A., Prikhodko I.G., Emelyanov A.A., Makhotina M.V. Experience of using the drug “Karipain Scar” in the children’s burn unit. Pediatric surgery. 2021;25(5):346–351. (In Russian). DOI: 10.18821/1560-9510-2021-25-5-346-351
35. Ermishina E.Yu., Elovikova T.M. Study of optical and physicochemical properties of dispersed aqueous systems of dental spray with titanium glycerosolvate aquacomplex and methylene blue used in the treatment of marginal gingivitis. In the collection: Innovative technologies in pharmacy. Proceedings of the All-Russian scientific and practical conference with international participation. General editor E.G. Privalova. Irkutsk; 2023:268–272. (In Russian).
36. Zamyatin A.V., Mager V.O., Orlov A.S., Ilyin K.A., Zavatsky S.E., Kovalenko D.A., Shcheglova V.P., Berzin S.A., Zyryanov A.V. Remote results of adjuvant intravesical chemotherapy with titanium glycerosolvate aquacomplex in patients with non-muscle-invasive bladder cancer. Oncourology. 2019;15(1):92–100. (In Russian). DOI: 10.17650/1726-9776-2019-15-1-92-100
37. Sekretnaya A.O., Zaderenko I.A., Ivanov S.Yu., Alieva S.B., Dymnikov A.B., Kaledin R.R., Alsayed Hashem H. Use of a titanium-containing drug for the prevention of severe degrees of radiation mucositis in patients with metal structures in the oral cavity. Head and Neck Tumors. 2021;11(4):81–85. (In Russian).
38. Barsukova K.V., Gorshkova O.M. Histochemical evaluation of the bone tissue regeneration process using the drug Tizol. Journal of Anatomy and Histopathology. 2013;2(3):58–60. (In Russian).
39. Grebneva O.L., Kovinka M.A., Silantyeva T.A., Gorbach E.N. Effect of blood serum components in the composition of a product for external use on reparative osteo-, keratogenesis and dermogenesis in an experiment. Genius of Orthopedics. 2010;3:135–140. (In Russian).
40. Martusevich A.K., Larionova K.D., Peretyagin S.P., Peretyagin P.V., Davydyuk A.V. Experimental evaluation of the influence of medicinal compositions on the state of microcirculation in the early post-burn period. Fundamental research. 2013;3(2):332– 336. (In Russian).
41. Sharonova N.A., Temkin E.S., Poroshin A.V. Clinical study of the effectiveness of using a natural combination drug in the treatment of chronic generalized periodontitis of moderate severity. Bulletin of the Volgograd State Medical University. 2019;1(69):65–68. (In Russian). DOI: 10.19163/1994-9480-2019-1(69)-65-68
42. Grebneva O.L., Silantyeva T.A., Kovinka M.A. Effect of plateletrich blood plasma in the composition of a product for external use on reparative osteogenesis (experimental study). Genius of Orthopedics. 2014;1:58–60. (In Russian).
43. Myakotnykh V.S., Tretyakov V.V., Borovkova T.A. Treatment of elderly and senile patients suffering from benign prostatic hyperplasia and chronic prostatitis. Advances in Gerontology. 2013;26(4):689– 695. (In Russian).
Review
For citations:
Feoktistova E.G., Emelyanov A.A., Andreev A.A., Glukhov A.A., Nikishina T.G. Titanium-containing medicinal products in medicine on the example of an aqua complex of titanium glycerosolvate. Clinical Medicine (Russian Journal). 2025;103(7):506-512. (In Russ.) https://doi.org/10.30629/0023-2149-2025-103-7-506-512
Views:
20
Email this article 