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Differential diagnosis of repolarization disorders in coronary heart disease and benign conditions on a resting electrocardiogram

https://doi.org/10.30629/0023-2149-2025-103-1-43-50

Abstract

Currently, with the abundance of scientific information, specialists face questions in interpreting repolarization disturbances for formulating an electrocardiographic diagnosis. The formulations accepted in domestic electrocardiography methodology, such as “focal changes in the myocardium” for coronary blood flow disorders, and “diffuse changes in the myocardium” for nonspecific repolarization disturbances, are not always related to coronary pathology. Furthermore, there is confusion in interpreting ECG signs of ischemia and/or myocardial damage in coronary pathology. The article reviews modern electrocardiographic criteria for diagnosing primary specific, nonspecific, and secondary repolarization disturbances in the myocardium that are most frequently encountered in clinical practice. The relevance of differential diagnosis of the causes of ST segment depression and elevation, T wave inversion on the ECG is due to the high frequency of pathological conditions underlying them, the difficulty of diagnosis, and significant differences in therapeutic tactics and disease prognosis. Modern concepts of the complex electrophysiological processes occurring in the heart under normal conditions, in myocardial hypertrophy, and at various stages of ischemic heart disease are outlined.

The aim of this work is to present current scientific data in the field of interpreting repolarization disturbances on resting ECGs in ischemic heart disease and benign conditions.

About the Authors

M. B. Patsenko
Military Medical Academy named after S.M. Kirov (Moscow branch) of the Ministry of Defense of Russia
Russian Federation

Mikhail B. Patsenko — Doctor of Medical Sciences, Associate Professor, Head of the Department of Emergency Medicine; Colonel of the Medical Service, Chief Therapist of the Russian Ministry of Defense, Honored Doctor of the Russian Federation

Moscow



V. I. Levin
Military Medical Academy named after S.M. Kirov (Moscow branch) of the Ministry of Defense of Russia
Russian Federation

Vladimir I. Levin — Lecturer at the Department of Emergency Medicine, Honored Doctor of the Russian Federation

AuthorID: 1125038

Moscow



I. N. Gaivoronskiy
Military Medical Academy named after S.M. Kirov (Moscow branch) of the Ministry of Defense of Russia
Russian Federation

Ivan N. Gaivoronskii — Candidate of Medical Sciences, Associate Professor of the Department of Emergency Medicine

AuthorID: 899062

Moscow



M. I. Pugachev
Military Medical Academy named after S.M. Kirov (Moscow branch) of the Ministry of Defense of Russia
Russian Federation

Maxim I. Pugachev — Candidate of Medical Sciences, Associate Professor of the Department of Emergency Medicine; Lieutenant Colonel of the Medical Service

AuthorID: 787395

Moscow



N. I. Gulyaev
Military Medical Academy named after S.M. Kirov (Moscow branch) of the Ministry of Defense of Russia; National Medical Research Center for High Medical Technologies — A.A. Vishnevsky Central Military Clinical Hospital of the Ministry of Defense of Russia
Russian Federation

Nikolay I. Gulyaev — Doctor of Medical Sciences, Associate Professor, Professor of the Department of Emergency Medicine; Head of the Cardiology Center Colonel of the Medical Service, Chief Specialist in Functional Diagnostics of the Ministry of Defense of the Russian Federation

AuthorID: 799762

Moscow; Krasnogorsk



A. A Prokhorchik
Military Medical Academy named after S.M. Kirov (Moscow branch) of the Ministry of Defense of Russia; National Medical Research Center for High Medical Technologies — A.A. Vishnevsky Central Military Clinical Hospital of the Ministry of Defense of Russia
Russian Federation

Alexander A. Prokhorchik — Candidate of Medical Sciences, Lecturer at the Department of Emergency Medicine; Chief Therapist at the National Medical Research Center for High Medical Technologies; Colonel of the Medical Service 

Moscow; Krasnogorsk



N. R. Nugaeva
Military Medical Academy named after S.M. Kirov (Moscow branch) of the Ministry of Defense of Russia
Russian Federation

Nelly R. Nugaeva — Candidate of Medical Sciences, Senior Lecturer at the Department of Emergency Medicine

AuthorID: 92210

Moscow



M. V. Palchenkova
Military Medical Academy named after S.M. Kirov (Moscow branch) of the Ministry of Defense of Russia
Russian Federation

Marina V. Palchenkova — Candidate of Medical Sciences, Associate Professor, Associate Professor of the Department of Emergency Medicine 

AuthorID: 92210

Moscow



L. I. Butorova
Military Medical Academy named after S.M. Kirov (Moscow branch) of the Ministry of Defense of Russia
Russian Federation

Lyudmila I. Butorova — Candidate of Medical Sciences, Lecturer at the Department of Emergency Medicine 

AuthorID: 781618

Moscow



L. I. Melnichenko
Military Medical Academy named after S.M. Kirov (Moscow branch) of the Ministry of Defense of Russia
Russian Federation

Larisa I. Melnichenko — a lecturer at the Department of Emergency Medicine

AuthorID: 1251037

Moscow



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Review

For citations:


Patsenko M.B., Levin V.I., Gaivoronskiy I.N., Pugachev M.I., Gulyaev N.I., Prokhorchik A.A., Nugaeva N.R., Palchenkova M.V., Butorova L.I., Melnichenko L.I. Differential diagnosis of repolarization disorders in coronary heart disease and benign conditions on a resting electrocardiogram. Clinical Medicine (Russian Journal). 2025;103(1):43-50. (In Russ.) https://doi.org/10.30629/0023-2149-2025-103-1-43-50

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ISSN 0023-2149 (Print)
ISSN 2412-1339 (Online)