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Micro-RNA and the epicardial fat thickness in patients with coronary artery disease with coronary artery stenosis
https://doi.org/10.30629/0023-2149-2024-102-9-10-754-759
Abstract
Objective: To assess the levels of microRNAs (miRs) and the thickness of epicardial adipose tissue (EAT) in patients with ischemic heart disease (IHD) and borderline coronary artery stenosis (CAS).
Material and methods. The study involved 201 patients with stable IHD of functional class (FC) 1–3, having borderline (50–70%) stenoses of the coronary arteries. The first group consisted of 57 (28.4%) patients with increased EAT thickness, while the second group included 144 (71.6%) patients without increased EAT thickness. The levels of the C-terminal fragment of pro-brain natriuretic peptide (NTproBNP) and miR levels (21m2, 133a, 208, 499a) were evaluated. EAT thickness was determined using echocardiography. All patients underwent coronary angiography.
Results. The average EAT thickness in the first group was 6.00 [5.00; 6.50] mm, while in the second group it was 3.00 [2.30; 4.00] mm (p < 0.001). Patients in the first group developed arterial hypertension (p < 0.001), IHD (p < 0.001) in general, and myocardial infarction (p = 0.003) at a younger age. There were no significant differences between the groups regarding the prevalence of obesity, type 2 diabetes, angina FC, or the frequency of use of all four main groups of anti-ischemic drugs. A higher level of miR-208 (p = 0.001) and a greater frequency of increased NTproBNP levels (p = 0.002) were found in patients with increased EAT thickness.
Conclusion. An elevated level of miR-208, a high frequency of increased NTproBNP, and a younger age at which cardiovascular diseases develop in patients with stable IHD and borderline CAS associated with increased EAT thickness may indicate a poorer prognosis, as they reflect the activity of cardiac remodeling.
About the Authors
Yu. O. Ostanina
Novosibirsk State Medical University
Russian Federation
Russian Federation
Yuliya O. Ostanina — Candidate of Medical Sciences, Associate Professor
Novosibirsk
D. A. Yakhontov
Novosibirsk State Medical University
Russian Federation
Russian Federation
Davyd A. Yakhontov — Doctor of Medical Sciences, Professor
Novosibirsk
V. L. Lukinov
Institute of Computational Mathematics and Mathematical Geophysics of the Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Vitaliy L. Lukinov — Candidate of Sciences (Physics and Mathematics), Senior Researcher, Head of the laboratories for Numerical Analysis of Stochastic Differential Equations
Novosibirsk
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Review
For citations:
Ostanina Yu.O., Yakhontov D.A., Lukinov V.L. Micro-RNA and the epicardial fat thickness in patients with coronary artery disease with coronary artery stenosis. Clinical Medicine (Russian Journal). 2024;102(9-10):754-759. (In Russ.) https://doi.org/10.30629/0023-2149-2024-102-9-10-754-759
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