Generate QR code
Open Access
Subscription Access
Lymphotropic therapy in the treatment of tuberculosis
https://doi.org/10.30629/0023-2149-2024-102-8-593-601
Abstract
One of the current issues in tuberculosis treatment is the intolerance to anti-tuberculosis drugs, which drives the search for the most effective method of delivering medications to the site of inflammation. A review of literature sources from the databases RSCI, Google Scholar, PubMed, and Scopus, covering the period from 1984 to 2020, was conducted, focusing on the use of endolymphatic therapy in patients with tuberculosis of various localizations. The analysis showed that the effectiveness of endolymphatic administration of anti-tuberculosis agents improves treatment outcomes for patients with progressive tuberculosis.
Supporting agencies: The work was carried out within the framework of the research topic 0515-2019-0017 “Development of surgical methods for the treatment of widespread tuberculosis of the respiratory system and the osteoarticular system”.
About the Authors
R. V. Tarasov
Central Research Institute of Tuberculosis; Moscow Medical University “Reaviz”; Russian Medical Academy of Continuing Professional Education of the Ministry of Healthcare of Russia
Russian Federation
Russian Federation
Ruslan V. Tarasov — Candidate of Medical Sciences, Researcher of the Department of Surgery; Associate Professor of the Department of Surgical Diseases; Assistant of the Department of Surgical Diseases
Moscow
A. M. Zakharova
Central Research Institute of Tuberculosis
Russian Federation
Russian Federation
Alexandra M. Zakharova — resident physician
Moscow
A. M. Tikhonov
Central Research Institute of Tuberculosis
Russian Federation
Russian Federation
Alexey M. Tikhonov — Candidate of Medical Sciences, Deputy Chief Physician
Moscow
E. V. Krasnikova
Central Research Institute of Tuberculosis
Russian Federation
Russian Federation
Elena V. Krasnikova — Doctor of Medical Sciences, Head of the 2nd Surgical Department
Moscow
S. S. Sadovnikova
Central Research Institute of Tuberculosis
Russian Federation
Russian Federation
Svetlana S. Sadovnikova — Doctor of Medical Sciences, Head of the 1st Surgical Department
Moscow
M. A. Bagirov
Central Research Institute of Tuberculosis; Russian Medical Academy of Continuing Professional Education of the Ministry of Healthcare of Russia
Russian Federation
Russian Federation
Mammed A. Bagirov — Doctor of Medical Sciences, Chief Researcher of the Department of Surgery; Professor of the Department of Thoracic Surgery
Moscow
References
1. Nechaeva O.B. The epidemic situation of tuberculosis in Russia. Tuberculosis and lung diseases. 2018;96(8):15–24. (In Russian)].
2. Panteleev A.M., Ivanov A.K., Vinogradova E.N. The use of regional lymphotropic therapy in the treatment of pulmonary tuberculosis in HIV-infected individuals. Problems of tuberculosis and lung diseases 2004;6:26–28. (In Russian)].
3. Bone C.R., Grodzin C.J., Balk R.A. Sepsis: a new hypothesis for pathogenesis of the disease process. Chest. 1997;112:235–242.
4. Vasilyeva I.A. et al. Morbidity, mortality and prevalence as indicators of the burden of tuberculosis in WHO regions, countries of the world and in the Russian Federation. Tuberculosis and lung diseases. 2017;95(6):9–21. (In Russian)].
5. Perelman M.I. Phthisiology. National leadership. Moscow. GEOTAR-Media. 2007:512. (In Russian)].
6. Patent of the Russian Federation for invention No. RU 2 281 093 C2:No. 2004132065/14: application 11.02.2004 : publ. 08.10.2006. Poltavtseva V.V., Chubaryan V.T., Poltavtseva E.G. Method of indirect regional lym photropic chemotherapy for infi ltrative, destructive and drug-resistant pul monary tuberculosis. (In Russian)]. [Electronic resource]. URL: https://patents.google.com/patent/RU2281093C2/ru Accessed 02/26/2024
7. Wolf S.B. Undesirable adverse reactions to tuberculosis chemotherapy. Journal of the Grodno State Medical University. 2016;3:141–146. (In Russian)].
8. Mordyk A.V. Frequency and pathogenesis of adverse adverse reactions to anti-tuberculosis drugs. Bulletin of Modern Clinical Medicine. 2010;3(1):16–21. (In Russian)].
9. Priestaiko Ya.I. Endolymphatic administration of drugs and surgical treatment of patients with widespread destructive pulmonary tuberculosis. Klin. Hir. 1997;(2):7–9. (In Russian)].
10. Sychev D.A., Dolzhenkova L.S., Prozorova V.K. Clinical pharmacology. General issues of clinical pharmacology: a practical course. Textbook. Edited by V.G. Kukes. M. GEOTAR-Media. 2013 (In Russian)].
11. Clinical pharmacology: national guidelines. Edited by Yu.B. Belousov, V.G. Kukes, V.K. Lepakhin, V.I. Petrov. M. GEOTAR-Media. 2014. (In Russian)].
12. Practical lymphology. Edited by Yu.M. Levin. Baku. Maarif. 1982:302. (In Russian)].
13. Panchenkov R.T., Vyrenkov Y.E., Yarema I.V., Shcherbakova E.G. Endolymphatic antibiotic therapy. M..: Medicine. 1984:240. (In Russian)].
14. Borodin Yu.I. Lymphology as an integrative medical and biological science. Bulletin of Lymphology. 2009(4):6–9. (In Russian)].
15. Mishin V.Yu., Myakisheva T.V., Mishina A.V. The eff ectiveness of various methods of administration of antituberculosis drugs in the IIB chemotherapy regimen in newly diagnosed patients with destructive pulmonary tuberculosis from the standpoint of evidence medicine. Practical medicine. 2011;3(51):63–67. (In Russian)].
16. To the use of lymphotropic therapy in the treatment of pulmonary tuberculosis in children and adolescents. Prevention of tuberculosis and its complicated forms in children and adolescents: Collection of scientifi c papers XII. M. 1989:100. (In Russian)].
17. Denisenko A.P. Method of endolymphatic administration of tuberculostatic drugs in the treatment of tuberculosis. Military medical journal. 1996;7:57–58. (In Russian)].
18. Ivanyuta O.M., Kovalenko N.N. The eff ectiveness of various methods of administration of chemotherapy drugs in patients with destructive pulmonary tuberculosis. Tuberculosis problems. 1983;2:40–43. (In Russian)].
19. Levin Yu.M. General clinical lymphology. Medical newspaper. 05/29/1994;39:8. (In Russian)].
20. Barmina H.A. Indirect lymphotropic therapy with the immunocorrector roncoleukin in the treatment of pulmonary tuberculosis in children and adolescents. Perm Medical Journal. 2006;4. (In Russian)].
21. A.S. Shprykov editor. Modern trends in epidemiology, diagnosis and occurrence of tuberculosis and other lung diseases. Nizhny Novgorod. NizhGMA Publishing House. 2009:187–194. (In Russian)].
22. Krotkova E.N., Gelberg S., Wolf B. The use of Roncoleukin lymphotropically in the treatment of common forms of pulmonary tuberculosis and its eff ect on cellular immunity. GrSMU Journal. 2004;3(7):62–64. (In Russian)].
23. Efimenko N.A., Chernekhovskaya N.E., Vyrenkov Yu.E. Guidelines for clinical lymphology. M. Polymag. 2001:158. (In Russian)].
24. Rogov K.N., Kukushkina E.K. Retrosternal lymphotropic administration of chemotherapy drugs in drug-resistant pulmonary tuberculosis. Bulletin of the Russian State Medical University. 2009;3. (In Russian)].
25. Peleneva I.M., Goryaeva N.A., Burukhina L.V. et.al. Optimization of indirect endolymphatic administration of isoniazid in pulmonary tuberculosis. Tuberculosis problems. 2002;11:24–26. (In Russian)].
26. Buyanov V.M., Danilov K.Yu., Radzikhovsky A.P. Drug saturation of the lymphatic system. Kiev. Medicine. 1991:12–18. (In Russian)].
27. Ovsyankina E.S. et al. The use of the regional lymphotropic method of drug administration in the diff erential diagnosis and complex treatment of tuberculosis in adolescents. Problems of tuberculosis and lung diseases. 2008;9:53–57. (In Russian)].
28. Vyrenkov Yu.E. et al. The use of lymphological methods in surgery and intensive care. Krasnodar. 2007:61. (In Russian)].
29. Poddubnaya L.V., Kononenko V.G., Shilova E.P. The use of complex parenteral chemotherapy in the treatment of destructive pulmonary tuberculosis in older children and adolescents. Tuberculosis and lung diseases. 2011;1:26–29. (In Russian)].
30. USSR patent for invention No. SU 1463299 A1 / 12.01.1987: published 07.03.1989. [Dzasokhov S.V., Stratonov V.M., Lev Ya.Yu., etc. A method of treating destructive pulmonary tuberculosis. (In Russian)]. [Electronic resource]. URL: https://yandex.ru/patents/doc/SU1463299A1_19890307?ysclid=lt1fddrie5482847738 Accessed 26.02.2024.
31. Kirillov Yu.V. et al. Adjuvant lymphotropic chemotherapy in the surgical treatment of progressive pulmonary tuberculosis. Tuberculosis and lung diseases. 2009;10:41–45. (In Russian)].
32. Petukhov V.P., Tsoktoev D. B. Complex treatment of tuberculosis of peripheral lymph nodes. BMJ. 2008;1. (In Russian)].
33. Dogorova O.E., Vinokurova M.K. The eff ectiveness of lymphotropic administration of anti–tuberculosis drugs in the chemotherapy of multidrug-resistant pulmonary tuberculosis. Tuberculosis and lung diseases. 2015;(6):51–52. (In Russian)].
34. Aseev A.V., Milyaev A.A. Retrosternal lymphotropic chemotherapy in tuberculosis patients/ HIV infection. Tuberculosis and lung diseases. 2015;(7):18–19. (In Russian)].
35. Patent of the Russian Federation No. RU 2 190 970 C2. / 99112339/14: application 07.06.1999: publ. 20.10.2002. Barinov V.S. Prokhorovich N.A. Rogozov L.I. Soldatova N.V. Method of treatment of tuberculosis of peripheral lymph nodes. (In Russian)]. [Electronic resource]. URL: https://patenton.ru/patent/RU2190970C2 Accessed 26.02.2024.
36. Lysov A.V., Nikonov S.D., Kazakov A.V. et.al. The eff ectiveness of lymphotropic administration of anti–tuberculosis drugs and roncoleukin in the complex treatment of adolescents with progressive pulmonary tuberculosis. Omsk Scientifi c Bulletin. 2009;1(84):79–82. (In Russian)].
37. Avdienko K.A., Krasnov D.V., Grishchenko N.G., Petrenko T.I. Peribronchial lymphotropic therapy in preoperative preparation of patients with tuberculosis of the respiratory system. Tuberculosis and lung diseases. 2016;94(10):44– 47. (In Russian)].
38. Dogorova O.E., Vinokurova M.K. The eff ectiveness of lymphotropic administration of anti–tuberculosis drugs in the chemotherapy of multidrug-resistant pulmonary tuberculosis. Tuberculosis and lung diseases. 2015;(6):51–52. (In Russian)].
39. Pletnev G.V., Krasnov D.V. Peribronchial lymphotropic therapy in the complex treatment of patients with progressive pulmonary tuberculosis. Tuberculosis problems. 2003;12:3–5. (In Russian)].
40. Popov V.A. Peribronchial administration of a drug mixture on a prolonged basis in the complex treatment of destructive pulmonary tuberculosis with multidrug resistance. Phthisiology and pulmonology. 2011;2:135. (In Russian)].
41. Avdienko K.A., Krasnov V.A., Krasnov D.V., Grishchenko N.G., Reichrud M.V., Kononenko V.G. Morphological picture of the bronchial wall at the site of resection in patients with pulmonary tuberculosis after peribronchial lymphotropic or inhalation therapy. Tuberculosis and lung diseases. 2018;96(12):49–54. (In Russian)].
42. Mishin V.Yu., Myakisheva T.V., Amaraeva L.V., Andrianova A.Yu., Borovitsky V.S., Lomova L.A. et al. Eff ectiveness of treatment of patients with destructive pulmonary tuberculosis in patients with parenteral and oral administration of anti–tuberculosis drugs. Pulmonology. 2011;1:55–59. (In Russian)].
43. Gubkina M.F. The eff ectiveness of the method of regional lymphotropic therapy in the complex treatment of pulmonary tuberculosis in adolescents. Tuberculosis problems. 1996;3:34–38. (In Russian)].
44. Aksenova V.A., Brichkova A.Yu. Endolymphatic management of isoniazid in the complex treatment of children with primary tuberculosis. Tuberculosis and ecology. 1995;1:37–40. (In Russian)].
45. Yagofarova R.K., Vakhmistrova T.I. Tuberculosis of the kidneys, ureters and bladder. Extrapulmonary tuberculosis. Handbook for doctors. St. Petersburg. ICF “Foliant”. 2000:276–290. (In Russian)].
46. Kulchavenya E.V. Diffi culties in diagnosing tuberculosis of the genitourinary system. Novosibirsk. Jupiter. 2004. (In Russian)].
47. Kulchavenya E.V. Posttuberculous cystalgia. Urol. nephrol., 1995;5:47–49. (In Russian)].
48. Baisova B.I. Gynecology. 4th ed. reprint. and additional Moscow: GEOTARMedia. 2014:406. (In Russian)].
49. Klinyshkova T.V., Yakovleva A.A. Female infertility associated with genital tuberculosis. Obstetrics, gynecology and reproduction. 2018;1:48–51. (In Russian)].
50. Shirinkina A.E., Shurygin A.A., Hvorostova I.V. et al. Clinical results of the use of lymphotropic therapy for genital tuberculosis. Tuberculosis and lung diseases. 2015;(7):158– 159. (In Russian)].
51. Petrov Yu.A., Shelemekh K.E. Genital tuberculosis is a disease requiring detection and treatment. The chief physician of the South of Russia. 2020;5:75. (In Russian)].
52. Patent RU 2 701 518 C1. application. 02/26/2019: publ. 09/27/2019. Shirinkina A.E., Pshenichnikova I.M., Ordina T.A., Shurygin A.A. Method of treatment of tuberculous adnexitis and/or endometritis. (In Russian)]. [Electronic resource]. URL: https://yandex.ru/patents/doc/RU2701518C1_20190927?ysclid=lt1g9ae1l9704058620 Accessed 26.02.2024
Review
For citations:
Tarasov R.V., Zakharova A.M., Tikhonov A.M., Krasnikova E.V., Sadovnikova S.S., Bagirov M.A. Lymphotropic therapy in the treatment of tuberculosis. Clinical Medicine (Russian Journal). 2024;102(8):593-601. (In Russ.) https://doi.org/10.30629/0023-2149-2024-102-8-593-601
Views:
377
Email this article 