Features of the blood lipid spectrum in men exposed to elevated noise levels
https://doi.org/10.30629/0023-2149-2023-101-11-556-561
Abstract
Dyslipidemia is the main factor in the initiation and progression of atherosclerosis. The search for probable factors aff ecting lipid metabolism is relevant. The aim of the study was to evaluate the parameters of lipid metabolism in the blood serum of men exposed to elevated noise levels. Material and methods. 293 men with no confi rmed atherosclerotic cardiovascular diseases were examined. Among the surveyed, 2 groups were identifi ed: 203 men who work under the infl uence of noise, and 90 men who do not come into contact with harmful production factors. Total cholesterol, triglycerides, low- and high-density lipoproteins, and the level of oxidized low-density lipoproteins were determined. Remnant cholesterol, atherogenic index and atherogenic plasma index were calculated. Results. Among persons under 55 years of age working in noise, an increase in total cholesterol (p = 0.02) and remnant cholesterol (p = 0.0006), a decrease in high-density lipoproteins (p = 0.03) and a tendency to increase the atherogenic index (p = 0.05) and the atherogenic plasma index (p = 0.07) were revealed. The prevalence of hypercholesterolemia was comparable in the main and control groups and amounted to 56.7 and 47.4%, respectively (p = 0.17). The median level of oxidized low-density lipoproteins in people working with noise did not exceed the upper limit of the norm. Conclusions. In men younger than 55 years old, working under conditions of exposure to increased noise levels, some features of the blood lipid spectrum are observed. The revealed changes may indicate an increase in the atherogenic potential of the blood serum
About the Authors
M. D. Rudoi
Nizhny Novgorod Research Institute of Hygiene and Occupational Pathology of Rospotrebnadzor; Privolzhsky Research Medical University of the Ministry of Health of the Russia
Russian Federation
Russian Federation
Rudoi Maria D.
603950, Nizhny Novgorod
603005, Nizhny Novgorod
E. V. Makarova
Nizhny Novgorod Research Institute of Hygiene and Occupational Pathology of Rospotrebnadzor; Privolzhsky Research Medical University of the Ministry of Health of the Russia
Russian Federation
Russian Federation
Makarova Ekaterina V.
603950, Nizhny Novgorod
603005, Nizhny Novgorod
L. A. Strakhova
Nizhny Novgorod Research Institute of Hygiene and Occupational Pathology of Rospotrebnadzor
Russian Federation
Russian Federation
Strakhova Larisa A.
603950, Nizhny Novgorod
Yu. V. Ivanova
Nizhny Novgorod Research Institute of Hygiene and Occupational Pathology of Rospotrebnadzor
Russian Federation
Russian Federation
Ivanova Yulia V.
603950, Nizhny Novgorod
References
1. Vasyutkina D.I. Industrial noise and its eff ect on the human body. Bulletin of BSTU named after V.G. Shukhov. 2013;1:125–128. (In Russian).
2. Virkkunen H., Kauppinen T., Tenkanen L. Long-term eff ect of occupational noise on the risk of coronary heart disease. Scand. J. Work. Environ. Health. 2005;31(4):291–299. DOI: 10.5271/sjweh.885
3. Pettersson H., Olsson D., Järvholm B. Occupational exposure to noise and cold environment and the risk of death due to myocardial infarction and stroke. Int. Arch. Occup. Environ. Health. 2020;93(5):571–575. DOI: 10.1007/s00420-019-01513-5
4. Babanov S.A., Baraeva R.A., Budash D.S. Lesions of the cardiovascular system in the practice of a professional pathologist. Medical almanac. 2016;4(44):106–111. (In Russian). URL: https://cyberleninka.ru/article/n/porazheniya-serdechno-sosudistoy-sistemy-v-praktike-vracha-profpatologa-1
5. Tessier-Sherman B., Galusha D., Cantley L.F., Cullen M.R., Rabinowitz P.M., Neitzel R.L. Occupational noise exposure and risk of hypertension in an industrial workforce. Am. J. Ind. Med. 2017;60(12):1031–1038. DOI: 10.1002/ajim.22775
6. Stokholm Z.A., Bonde J.P., Christensen K.L., Hansen A.M., Kolstad H.A. Occupational noise exposure and the risk of hypertension. Epidemiology. 2013;24(1):135–42. DOI: 10.1097/EDE.0b013e31826b7f76
7. Lousinha A., Antunes E., Borrecho G., Oliveira M.J., Brito J., dos Santos J.M. Histomorphometric evaluation of the small coronary arteries in rats exposed to industrial noise. Int. J. Mol. Sci. 2015;16(5):10095–104. DOI: 10.3390/ijms160510095
8. Diagnosis and correction of lipid metabolism disorders for the prevention and treatment of atherosclerosis. Russian recommendations, VII revision. Atherosclerosis and dyslipidemia. 2020;1(38):7–42. (In Russian). DOI: 10.34687/2219-8202.JAD.2020.01.0002
9. Zvenigorodskaya L.A., Churikova A.A. The role of modifi ed lipoproteins in the development of atherogenic dyslipidemia. Experimental and clinical gastroenterology. 2011;11:73–78. (In Russian). URL: https://cyberleninka.ru/article/n/rol-modifitsirovannyh-lipoproteinov-v-razvitii-aterogennoy-dislipidemii
10. Shogenova M.H., Zhetisheva R.A., Karpov A.M., Dotsenko Yu.V., Masenko V.P., Naumov V.G. The role of oxidized low-density lipoproteins and antibodies to them in the immune-infl ammatory process in atherosclerosis. Atherosclerosis and dyslipidemia. 2015;2:17–21. (In Russian)]. URL: https://cyberleninka.ru/article/n/rol-okislennyh-lipoproteinov-nizkoy-plotnosti-i-antitel-k-nim-v-immunno-vospalitelnom-protsesse-pri-ateroskleroze
11. Kattoor A.J., Kanuri S.H., Mehta J.L. Role of Ox-LDL and LOX-1 in Atherogenesis. Curr. Med. Chem. 2019;26(9):1693–1700. DOI: 10.2174/0929867325666180508100950
12. Zhang K., Jiang F., Luo H., Liu F. Occupational noise exposure and the prevalence of dyslipidemia in a cross-sectional study. BMC Public Health. 2021;21(1):1258. DOI: 10.1186/s12889-021-11274-x
13. Arlien-Søborg M.C., Schmedes A.S., Stokholm Z.A., Grynderup M.B., Bonde J.P., Jensen C.S., Hansen Å.M., Frederiksen T.W., Kristiansen J., Christensen K.L., Vestergaard J.M., Lund S.P., Kolstad H.A. Ambient and at-the-ear occupational noise exposure and serum lipid levels. Int. Arch. Occup. Environ. Health. 2016;89(7):1087–1093. DOI: 10.1007/s00420-016-1145-3
14. Muromtseva G.A., Kontsevaya A.V., Konstantinov V.V. et al. Prevalence of risk factors for noncommunicable diseases in the Russian population in 2012 –2013. The study ESSE-RF. Kardiovaskulyarnaya Terapiya i Profi laktika. 2014;6:4–11. (In Russian). DOI: 10.15829/1728-8800-2014-6-4-11
15. Vasiliev A.P., Streltsova N.N. Cholesterol and its biological signifi cance. Atherosclerosis. Statin therapy (Part 1). The Siberian Journal of Clinical and Experimental Medicine. 2022;37(1):27–35. (In Russian)]. DOI: 10.29001/2073-8552-2022-37-1-27-35
16. Tada H., Nohara A., Inazu A., Mabuchi H., Kawashiri M.A. Remnant lipoproteins and atherosclerotic cardiovascular disease. Clin. Chim. Acta. 2019;490:1–5. DOI: 10.1016/j.cca.2018.12.014
17. Langsted A., Nordestgaard B.G. Elevated Remnant Cholesterol Reclassifi es Risk of Ischemic Heart Disease and Myocardial Infarction. J. Am. Coll. Cardiol. 2022;79(24):2383–2397. DOI: 10.1016/j.jacc.2022.03.384
18. Pownall H.J., Rosales C., Gillard B.K., Gotto A.M. Jr. High-density lipoproteins, reverse cholesterol transport and atherogenesis. Na.t Rev. Cardiol. 2021Oct;18(10):712–723. DOI: 10.1038/s41569-021-00538-z
19. Sirtori C.R., Corsini A., Ruscica M. The Role of High-Density Lipoprotein Cholesterol in 2022. Curr. Atheroscler. Rep. 2022;24(5):365– 377. DOI: 10.1007/s11883-022-01012-y
20. Grinshtein Yu.I., Shabalin V.V., Ruf R.R., Shalnova S.A., Drapkina O.M. Atherogenic index of plasma as an additional marker of adverse cardiovascular outcomes. Cardiovascular Therapy and Prevention. 2022;21(5):3176. (In Russian) DOI: 10.15829/1728-8800-2022-3176
21.
Review
For citations:
Rudoi M.D., Makarova E.V., Strakhova L.A., Ivanova Yu.V. Features of the blood lipid spectrum in men exposed to elevated noise levels. Clinical Medicine (Russian Journal). 2023;101(11):556-561. (In Russ.) https://doi.org/10.30629/0023-2149-2023-101-11-556-561
Views:
523
Email this article 