Preview

Clinical Medicine (Russian Journal)

Advanced search

Changes in the blood coagulation system in patients with chronic heart failure

https://doi.org/10.30629/0023-2149-2023-101-4-5-181-187

Abstract

The article provides a review of scientifi c publications dedicated to the study of the hemostatic system in patients with chronic heart failure (CHF). Russian and foreign authors evaluated the risks of bleeding and thrombosis in patients with CHF, as well as changes in the content of individual markers and factors of the coagulation system. The review suggests that the results obtained are quite contradictory. On the one hand, data is presented on an increased risk of thrombosis, changes in the content of some endothelial markers that promote endothelial thrombogenicity, an increase in the content of platelet aggregation markers, and elevated levels of fi brinogen and thrombin. On the other hand, there is data on an increased risk of bleeding in patients with CHF, an increase in some endothelial markers that enhance the anticoagulant properties of the endothelium. From the analysis conducted, it can be concluded that this topic is not suffi  ciently studied, and it is diffi  cult to judge the hemostatic potential in patients with CHF at present. The use of integrated methods such as thromboelastography (TEG) and low-frequency piezothromboelastography (LF-PTEG) are a promising direction for studying this problem. The results obtained using these methods will likely allow for a more precise understanding of the features of the coagulation system functioning in patients with CHF.

About the Authors

Yu. V. Ovchinnikov
Military Medical Academy named after S.M. Kirov (Moscow branch) of the Ministry of Defense of Russia
Russian Federation

Ovchinnikov Yuri V.

107392, Moscow



M. B. Patsenko
National Medical Research Center of High Medical Technologies — A.A. Vishnevsky Central Military Clinical Hospital of the Ministry of Defense of Russia
Russian Federation

Patsenko Mikhail B.

143420, Krasnogorsk



N. I. Gulyaev
Military Medical Academy named after S.M. Kirov (Moscow branch) of the Ministry of Defense of Russia; National Medical Research Center of High Medical Technologies — A.A. Vishnevsky Central Military Clinical Hospital of the Ministry of Defense of Russia
Russian Federation

Gulyaev Nikolay I.

107392, Moscow

143420, Krasnogorsk



M. A. Lebedev
Military Medical Academy named after S.M. Kirov (Moscow branch) of the Ministry of Defense of Russia
Russian Federation

Lebedev Maxim A.

107392, Moscow



References

1. Dunlay S.M., Roger V.L., Redfi eld M.M. Epidemiology of heart failure with preserved ejection fraction. Nature reviews Cardiology. 2017;14(10):591–602. DOI: 10.1038/nrcardio.2017.65

2. Tsao C.W., Aday A.W., Almarzooq Z.I., Alonso A., Beaton A.Z., Bittencourt M.S., Boehme A.K., Buxton A.E., Carson A.P., Commodore–Mensah Y., Elkind M.S.V., Evenson K.R., Eze–Nliam C., Ferguson J.F., Generoso G., Ho J.E., Kalani R., Khan S.S., Kissela B.M., Knutson K.L., Levine D.A., Lewis T.T., Liu J., Loop M.S., Ma J., Mussolino M.E., Navaneethan S.D., Perak A.M., Poudel R., Rezk–Hanna M., Roth G.A., Schroeder E.B., Shah S.H., Thacker E.L., VanWagner L.B., Virani SS., Voecks J.H., Wang N.Y., Yaff e K., Martin S.S. Heart disease and Stroke Statistics—2022. Update: A report from the American Heart Association. Circulation. 2022;145(8):153–639. DOI: 10.1161/CIR.0000000000001052

3. Tereshchenko S.N., Galyavich A.S., Uskach T.M. Chronic heart failure. Clinical recommendations of the Ministry of Health of the Russian Federation. 2020:14–15. (In Russian)].

4. Polyakov D.S., Fomin Yi.V., Belenkov Yu.N., Mareev V.Yu., Ageev F.T., Artemyeva.Е.G., Badin Yu.V., Baculina Е.V., Vinogradova N.V., Galjavic A.S., Ionova T.S. Kamalov G.M., Kechedzhie va S.G., Koziolova N.A., Malenkova V.Yu., Malchikova S.V., Mareev Yu.V., Smirnova E.A., Tarlovskaya E.I., Shterbinina E.V., Yakushin S.S. Chronic heart failure in the Russian Federation: what has changed in 20 years of observation? The results of the EPOCH– CHF study. Cardiology. 2021;61(4):10–12. (In Russian)].

5. Glagoleva D.A., Mironov N.Yu., Lainovich L.Yu., Mironova N.A., Golitsyn S.P. Interrelation of atrial fi brillation and chronic heart failure. Modern approaches to treatment. Cardiological Bulletin. 2021;16(2):5–14. (In Russian)].

6. Tang L., Wu Y.Y., Lip G.Y,. Yin P., Hu Y. Heart failure and risk of venous thromboembolism: a systematic review and meta–analysis. The Lancet Haematology. 2016;3(1):30–44. DOI: 10.1016/S2352–3026(15)00228–8

7. Shantsila E., Lip GY. Thrombotic Complications in Heart Failure An Underappreciated Challenge. Circulation. 2014;130(5):387–389. DOI: 10.1161/CIRCULATIONAHA.114.011353

8. Bounameaux H., Agnelli G. Symptoms and clini cal relevance: a dilemma for clinical trials onpre ven tion of venous thromboembolism. Thrombosis and Haemo sta sis. 2013;109:585–598. DOI: 10.1160/TH12–08–0627

9. Al Yami M.S., Kurdi S., Abraham I. Direct oral anticoagulants for extended thromboprophylaxisin medically ill patients: meta–analysis and risk/benefi t assessment. Journal of Blood Medicine. 2018;9:25– 34. DOI:10.2147/JBM.S149202

10. Vinogradova N.G., Zhirkova M.M., Polyakov D.S., Kraem N., Fomin I.V. Anticoagulant therapy and prognosis in patients with CHF and AF in real clinical practice. Cardiology. 2017;57(4):4–10. (In Russian)]. DOI: 10.18087/cardio.2430

11. Jackevicius C.A., Lu L., Ghaznavi Z., Warner A.L. Bleeding risk of direct oral anticoagulants in patients with heart failure and atrial fi brillation. Circulation: Cardiovascular Quality and Outcomes. 2021;14(2):207230. DOI: 10.1161/CIRCOUTCOMES.120.007230

12. Manal M.A. Endothelial Dysfunction in Chronic Heart Failure: Assessment, Findings, Signifi cance, and Potential Therapeutic Targets. International Journal of Molecular Sciences. 2019;20(13):31–98. DOI:10.3390/ijms20133198

13. Maréchaux S., Samson R., van Belle E., Breyne J., de Monte J., Dédrie C., Chebai N., Menet A., Banfi C., Bouabdallaoui N., Le Jemtel T.H., Ennezat P.V. Vascular and Microvascular Endothelial Function in Heart Failure With Preserved Ejection Fraction. Journal of Cardiac Failure. 2016;22(1):3–11. DOI: 10.1016/j.cardfail.2015.09.003

14. Kishimoto S., Kajikawa M., Maruhashi T., Iwamoto Y., Matsumoto T., Iwamoto A., Oda N., Matsui S., Hidaka T., Kihara Y., Chayama K., Goto C., Aibara Y., Nakashima A., Noma K., Higashi Y. Endothelial dysfunction and abnormal vascular structure are simultaneously present in patients with heart failure with preserved ejection fraction. International Journal of Cardiology. 2017;231:181–187. DOI: 10.1016/j.ijcard.2017.01.024

15. Fujisue K., Sugiyama S., Matsuzawa Y., Akiyama E., Sugamura K., Matsubara J., Kurokawa H., Maeda H., Hirata Y., Kusaka H., Yamamoto E., Iwashita S., Sumida H., Sakamoto K., Tsujita K., Kaikita K., Hokimoto S., Matsui K., Ogawa H. Prognostic signifi cance of peripheral microvascular endothelial dysfunctionin heart failure with reduced left ventricular ejection fraction. Circulation Journal. 2015;79(12):2623–2631. DOI: 10.1253/circj.CJ–15–0671

16. Pearson M.J., Smart N.A. Eff ect of exercise training on endothelial function in heart failure patients: A systematic review meta–analysis. International Journal of Cardiology. 2017;231:234–243. DOI: 10.1016/j.ijcard.2016.12.145

17. Ennis S., McGregor G., Shave R., McDonnell B., Thompson A., Banerjee P., Jones H. Low frequency electrical muscle stimulation and endothelial function in advanced heart failure patients. European Society of Cardiology — Heart Failure Journal. 2018;5(4):727–731. DOI: 10.1002/ehf2.12293

18. Atakhodzhaeva G.A., Rakhimov Sh.M., Azimova N.Z. The state of endothelial function in patients with chronic heart failure with various manifestations of metabolic syndrome. Cardiology and cardiovascular surgery. 2015;8(3):76– 80. (In Russian)]. DOI: 10.17116/kardio20158376–80

19. Kamilova U.K., Abdull aev C.A. Study of indicators of endothelial dysfunction and oxidative stress in patients with chronic heart failure. Eurasian Journal of Internal Medicine. 2014;1:24–35. (In Russian)].

20. Cugno M., Mari D., Meroni P.L., Gronda E., Vicari F., Frigerio M., Coppola R., Bottasso B., Borghi M.O., Gregorini L. Haemostatic and infl ammatory biomarkers in advancedchronic heart failure: role of oral anticoagulants and successfulheart transplantation. British Journal of Haematology. 2004;126:85–92. DOI: 10.1111/j.1365–2141.2004.04977.x

21. Vila V., Martínez–Sales V., Almenar L., Lázaro I.S., Villa P., Re gan on E. Infl ammation, endothelial dysfunction and angio–genesis markers in chronic heart failure patients. International Journal of Cardiology. 2008;130(2):276–287. DOI: 10.1016/j.ijcard.2007.07.010

22. Chong A.Y., Freestone B., Patel J., Lim H.S., Hughes E., Blann A.D., Lip G.Y. Endothelial activation, dysfunction and damage incongestive heart failure and the relation to brain natriuretic peptide and outcomes American Journal of Cardiology. 2006;97(5):671–675. DOI: 10.1016/j.amjcard.2005.09.113

23. Chong A.Y., Freestone B., Lim H.S., Kistorp C., Gustafsson F., Hildebrandt P., Lip G.Y. Plasma von Willebrand factor and soluble E-selectin levels in stabile outpatients with systolic heart failure: the Fre–dericksburg heart failure study. International Journal of Cardiology. 2007;119(1):80–92. DOI: 10.1016/j.ijcard.2006.07.085

24. Chin B.S., Gibbs C.R., Blann A.D., Lip G.Y. Neither carvedilol nor bisoprolol in maximally tolerated doses has any specifi c advantage in lowering chronic heart failure oxidant stress: implications for betablocker selection Clinical Science. 2003;105(4):507–512. DOI: 10.1042/CS20030172

25. Mehta J., Mehta P. Platelet function studies in heart disease. Enhanced platelet aggregate formation activity in congestive heart failure: inhibition by sodium nitroprusside. Circulation. 1979;60(3):497–503. DOI: 10.1161/01.cir.60.3.497

26. Mongirdienė A., Laukaitienė J., Skipskis V., Kuršvietienė L., Liobikas J. Platelet Activity and Its Correlation with Infl ammation and Cell Count Readings in Chronic Heart Failure Patients with Reduced Ejection Fraction. Medicina (Kaunas). 2021;57(2):176. DOI: 10.3390/medicina57020176

27. Altieri P., Brunelli C., Garibaldi S., Nicolino A., Ubaldi S., Spallarossa P., Olivotti L., Rossettin P., Barsotti A., Ghigliotti G. Metalloproteinases 2 and 9 are increased in plasma of patients with heart failure. European Journal of Clinical Investigation. 2003;33(8):648–56. DOI: 10.1046/j.1365–2362.2003.01187.x

28. Gurbel P.A., Bliden K.P., Hayes K.M., Tantry U. Platelet activation in myocardial ischemic syndromes. Expert Review of Cardiovascular Therapy. 2004;2(4):535–545. DOI: 10.1586/14779072.2.4.535

29. Ueland T., Aukrust P., Yndestad A., Otterdal K., Frøland S.S., Dickstein K., Kjekshus J., Gullestad L., Damås J.K. Soluble CD40 ligand in acute and chronic heart failure. European Journal of Clinical Investigation. 2005;26(11):1101–7. DOI: 10.1093/eurheartj/ehi132

30. O’Connor C.M., Gurbel P.A., Serebruany V.L. Usefulness of soluble and surface-bound P-selectin in detecting heightened platelet activity in patients with congestive heart failure. American Journal of Cardiology. 1999;83(9):1345–9. DOI: 10.1016/s0002–9149(99)00098–3

31. Yin W.H., Chen J.W., Jen H.L., Chiang M.C., Huang W.P., Feng A.N., Lin S.J., Young M.S. The prognostic value of circulating soluble cell adhesion molecules in patients with chronic heart failure. European Journal of Heart Failure. 2003;5(4):507–516. DOI: 10.1016/s1388–9842(03) 00009–6

32. van Deursen V.M., Edwards C., Cotter G., Davison B.A., Damman K., Teerlink J.R., Metra M., Felker G.M., Ponikowski P., Unemori E., Severin T., Voors A.A. Liver function, in-hospital, and postdischarge clinical outcome in patients with acute heart failureresults from therelaxin for the treatment of patients with acute heart failure study. Journal of Cardiac Failure. 2014;20(6):407–413. DOI: 10.1016/j.cardfail.2014.03.003

33. Brisco M.A., McCauley B.D., Chen J., Parikh C.R., Testani J.M. Biochemical evidence of mild hepatic dysfunction identifi es decompensated heart failure patients with reversiblerenal dysfunction. Journal of Cardiac Failure. 2013;19(11):739–745. DOI: 10.1016/j.cardfail.2013.10.005

34. Sánchez–Lázaro I.J., Almenar L., Reganon E., Vila V., Martínez–Dolz L., Martínez–Sales V., Moro J., Agüero J., Ortiz–Martínez V., Salvador A. Infl ammatory markers in stabile heart failure and their relationship with functional class. International Journal of Cardiology. 2008;129(3):388–93. DOI: 10.1016/j.ijcard.2007.07.138

35. Pronin A.G., Valova O.A. New possibilities for assessing the level of D-dimer in the diagnosis of pulmonary embolism in patients with chronic heart failure. N.V. Sklifosovsky Journal “Emergency medical care”. 2017;6(3):216–220. (In Russian)]. DOI: 10.23934/2223–9022–2017–6–3–216–220

36. Andrzejczak-Karbowska M., Irzmański R. The impact of the dosing, a 12-week physical training on the concentration of NT-proBNP and D-Dimer in patients with heart failure and impaired functional capacity in VII–X decade of life. Polski Merkuriusz Lekarski. 2016;41(241):11–15. Polish. PMID: 27734814

37. Mongirdiene A., Kursvietiene L., Kasauskas A. The coagulation system changes in patients with chronic heart failure. Medicina (Kau nas). 2010;46(9):642–657. https://pubmed.ncbi.nlm.nih.gov/21252600/

38. Bula nov A.Yu. Thromboelastography in modern clinical practice atlas TAG. Moscow. Newdiamed. 2015:114. (In Russian)].

39. Mann K.G., Whelihan M.F., Butenas S., Orfeo T. Citrate anticoagulation and the dynamics of thrombin generation. Journal of Thrombosis and Haemostasis. 2007;5(10):2055–2061. DOI: 10.1111/j.1538–7836.2007.02710.x

40. Tyutrin I.I., Udut V.V. Low-frequency piezothromboelastography of whole blood: algorithms for diagnosis and correction of hemostatic disorders. Tomsk, Publishing House of Tomsk State University. 2016:170. (In Russian)].


Review

For citations:


Ovchinnikov Yu.V., Patsenko M.B., Gulyaev N.I., Lebedev M.A. Changes in the blood coagulation system in patients with chronic heart failure. Clinical Medicine (Russian Journal). 2023;101(4-5):181-187. (In Russ.) https://doi.org/10.30629/0023-2149-2023-101-4-5-181-187

Views: 574


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 0023-2149 (Print)
ISSN 2412-1339 (Online)