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From blood to saline solutions: a paradigm shift in the 19th century
https://doi.org/10.30629/0023-2149-2025-103-6-480-488
Abstract
The article provides a comprehensive study of statistical data on the number of performed hemotransfusions, intravenous injections of salt and milk solutions in clinical practice of the XIX century. A bibliometric analysis of the frequency of citation of these data in the Ngram Google books system was performed. The periods of the most active experimental study and practical use of these procedures, occurring in 1830–1840 and 1870–1880, are revealed. The reasons for the paradigm shift in transfusiology during the 19th century have been established, refl ected in the simultaneous increase in popularity of one and the decline of the other treatment methods. These processes could be caused by the direct results of the use of blood transfusions and blood substitutes during military confl icts and the cholera epidemic, progress in the fi eld of experimental physiology, as well as the introduction into clinical practice of new methods of administration of infusion drugs.
About the Authors
M. S. Sergeeva
I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of the Russia (Sechenovskiy University)
Russian Federation
Russian Federation
Maria S. Sergeeva — Candidate of Historical Sciences, Associate Professor, Institute of Social Sciences
Moscow
N. N. Krylov
I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of the Russia (Sechenovskiy University)
Russian Federation
Russian Federation
Nikolay N. Krylov —Doctor of Medical Sciences, Professor of Institute of Social sciences
Moscow
A. A. Zobova
I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of the Russia (Sechenovskiy University)
Russian Federation
Russian Federation
Anna A. Zobova — student
Moscow
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Review
For citations:
Sergeeva M.S., Krylov N.N., Zobova A.A. From blood to saline solutions: a paradigm shift in the 19th century. Clinical Medicine (Russian Journal). 2025;103(6):480-488. (In Russ.) https://doi.org/10.30629/0023-2149-2025-103-6-480-488
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