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Medical consequences of tattoos

https://doi.org/10.30629/0023-2149-2025-103-6-426-433

Abstract

This paper highlights aspects of the increasing prevalence of tattoos and their medical consequences. Tattoo inks, the composition of which is poorly understood, are capable of provoking development of various types of cutaneous and systemic reactions. A description and brief comments on the main types of medical eff ects of tattooing tattoos, often due to their extended colour range and other factors. A clinical case of lymphadenopathy in a patient with multiple tattoos on the body is presented.

About the Authors

P. E. Krainyukov
Central Military Clinical Hospital named P.V. Mandryka of the Ministry of Defence of the Russia; Peoples' Friendship University of Russia named after Patrice Lumumba
Russian Federation

Pavel E. Krainyukov — Doctor of Medical Sciences, Professor, Corresponding Member of the RAS, Head of the P.V. Mandryk; Professor of the Department of Hospital Surgery with a course in Pediatric Surgery

Moscow



V. B. Simonenko
Branch Military Medical Academy named after S.M. Kirov in Moscow of the Ministry of Defense of the Russia
Russian Federation

Vladimir B. Simonenko — Doctor of Medical Sciences, Professor, Corresponding Member of the Russian Academy of Sciences, Professor of the Department of Emergency Medicine

Moscow



S. Kh. Sarmanaev
Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of the Federal Medical Biological Agency; Academy of Postgraduate Education of the Federal State Budgetary Institution Federal Scientifi c and Clinical Center for Specialized Types of Medical Care and Medical Technologies of the Federal Medical and Biological Agency
Russian Federation

Salavat Kh. Sarmanaev — Doctor of Medical Sciences, Professor, Deputy Head of the Toxicological Center of the Federal State Budgetary Institution; Head of the Department of Toxicology and Clinical Pharmacology

Moscow



N. A. Shikhta
Clinical Hospital No. 51 of the Federal Medical Biological Agency
Russian Federation

Natalia A. Shikhta — Head of the Therapeutic Department No. 2

Zheleznogorsk, Krasnoyarsk krai



E. A. Shikhta
Clinical Hospital No. 51 of the Federal Medical Biological Agency
Russian Federation

Evgeny A. Shikhta — Head of the Pathology Department

Zheleznogorsk, Krasnoyarsk krai



P. A. Dulin
Branch Military Medical Academy named after S.M. Kirov in Moscow of the Ministry of Defense of the Russia
Russian Federation

Pyotr A. Dulin — Doctor of Medical Sciences, Associate Professor, Associate Professor of the Department of Emergency Medicine

Moscow



References

1. Wohlrab S. et al. Modifying the body: motivations for getting tattooed and pierced. Body Image. 2007;4(1):87–95.

2. Large Medical Encyclopaedia, 1970. (In Russian).

3. Ortiz A.E. et al. Rising concern over cosmetic tattoos. Dermatologic surgery: offi cial publication for American Society for Dermatologic Surgery.2012;38:424–9.

4. Kluger N. et al. Tattooing: A national survey in the general population of France. J. Am. Acad. Dermatol. 2019;81(2):607–610.

5. Borkenhagen A. et al. Verbreitung von Tätowierungen, Piercing und Körperhaarentfernung in Deutschland. press release University of Leipzig: University of Leipzig. 2017.

6. Shannon-Missal L. Tattoo Takeover: Three in Ten Americans Have Tattoos, and Most Don’t Stop at Just One. In: Poll T.H., editor. URL: https://theharrispoll.com2016

7. Laumann A.E. et al. Tattoos and body piercings in the United States: a national data set. J. Am. Acad. Dermatol. 2006;55:413–21.

8. Borkenhagen A. et al. Tattoos in der deutschen Bevölkerung — Prävalenzen, Soziodemografe und Gesundheitsorientierung. Bundesgesundheitsbl. 2019;62(9):1077–1082.

9. Negi S. et al. Tattoo inks are toxicological risks to human health: A systematic review of their ingredients, fate inside skin, toxicity due to polycyclic aromatic hydrocarbons, primary aromatic amines, metals, and overview of regulatory frameworks. Tоxicol Ind Health. 2022;38(7):417–434.

10. Wang X. et al. Analytical survey of tattoo inks a chemical and legal perspective with focus on sensitizing substance. Contact Dermatitis. 2021;85(3):340–353.

11. Klügl I. et al. Incidence of health problems associated with tattooed skin: a nation-wide survey in German-speaking countries. Dermatology. 2010;221(1):43–50.

12. Huisman S. et al. Cutaneous non-allergic complications in tattoos: an overview of the literature. La Presse Médicale. 2020.104049. DOI: 10.1016/j.lpm.2020.104049

13. Shinohara M.M. Complications of decorative tattoo. Clinics in Dermatology. 2016;34(2),287–292.

14. Kazandjieva J. et al. Tattoos: dermatological complications. Clin. Dermatol. 2007;25(4):375-82.

15. Høgsberg T. et al. Microbial status and product labelling of 58 original tattoo inks. J. Eur. Acad. Dermatol. Venereol. 2013;27(1):73–80.

16. Kluger N. Systemic diseases and infections, anecdotal complications and oddities associated with tattooing. Presse Med. 2020;49:104055. DOI: 10.1016/j.lpm.2020.104055

17. Wolf R. et al. A tattooed butterfl y as a vector of atypical Mycobacteria. J. Am. Acad. Dermatol. 2003;48(5):S73–S74.

18. Charifa A. et al. StatPearls. StatPearls Publishing; St. Petersburg, FL, USA: 2023. Cutaneous Tuberculosis.

19. Ghorpade A. Inoculation (tattoo) leprosy: A report of 31 cases. J. Eur. Acad. Dermatol. Venereol. 2002;16:494–499.

20. Urbanus A.T. et al. People with multiple tattoos and/or piercings are not at increased risk for HBV or HCV in the Netherlands. PLoS One. 2011;6(9):e24736.

21. Karymov O.N. et al. Classifi cation of complications of tattooing. Clinical Dermatology and Venereology. 2018;17(6):98–107. (In Russian).

22. Kirchhof M.G. et al. Tattoos and human papilloma virus: A case report of tattoo-associated fl at warts (verrucae planae). SAGE Open Med. Case Rep. 2019;19(7):2050313X19857416.

23. Kluger N. et al. Molluscum contagiosum sur tatouage. Ann. Dermatol. Venereol. 2007;134:506–507.

24. Begolli Gerqari A. et al. Activation of Herpes Simplex Infection after Tattoo. Acta Dermatovenerol. Croat. 2018;26(1):75–76.

25. Kluger N. Viral warts and seborrhoeic keratoses on tattoos: A review of nine cases. J. Eur. Acad. Dermatol. Venereol. 2017;31:e340–e342.

26. Sáez M. et al. Multiple verrucae vulgaris in a young woman’s tattoo. J. Eur. Acad. Dermatol. Venereol. 2006;20:356–357.

27. Filipović N. et al. Flat Warts (Verrucae Planae) Confi ned to the Pigment of a Tattoo: A Rare Tattoo-associated Complication. Acta Dermatovenerol. Croat. 2023;31(2):112–114.

28. van der Bent S.A.S. et al. Complications of tattoos and permanent makeup: overview and analysis of 308 cases. J. Cosmet. Dermatol. 2021;20(11):3630–3641.

29. Islam P.S. et al. Complications of Tattoos: A Comprehensive Review. Clin. Rev. Allerg. Immunol. 2016;50:273–286.

30. Thum C.K. et al. Infl ammatory complications related to tattooing: a histopathological approach based on pattern analysis. Am. J. Dermatopathol. 2015;37:54–66.

31. Sepehri M. et al. Papulo-Nodular Reactions in Black Tattoos as Markers of Sarcoidosis: Study of 92 Tattoo Reactions from a Hospital Material. Dermatology. 2016;232(6):679–686.

32. Tsang M. et al. A visible response to an invisible tattoo. J. Cutan. Pathol. 2012;39:877–80.

33. Kluger N. An update on cutaneous complications of permanent tattooing. Expert Rev. Clin. Immunol. 2019;15(11):1135–1143.

34. Laux P. et al. A medical-toxicological view of tattooing. The Lancet. 2016;387(10016):395–402.

35. Hutton Carlsen K. et al. Tattooist-associated tattoo complications: “Overworked Tattoo”, “Pigment Overload” and infections producing early and late adverse events. Dermatology. 2019;9:1–8.

36. Cristaudo et al. Permanent tattoos: evidence of pseudolymphoma in three patients and metal composition in the dyes. Europ. J. Dermatol. 2012;22:776–80.

37. Kiszla B.M. et al. Quantitative analysis of restricted metals and metalloids in tattoo inks: A systematic review and meta-analysis. Chemosphere. 2023;313:137291.

38. Tammaro A. et al. Tridimensional Matryoshka Tattoo: An Important. Acta Dermatovenerol. Croat. 2019;27(3):198–199.

39. Colboc H. et al. Chemical characterization of inks in skin reactions to tattoo. J. Synchrotron Radiat. 2022;1;29(6):1436–1445.

40. Serup J., Hutton Carlsen K., Dommershausen N., Sepehri M., Hesse B., Seim C., Luch A., Schreiver I. Identifi cation of pigments related to allergic tattoo reactions in 104 human skin biopsies. Contact. Dermat. 2020;82:73–82.

41. Schubert S. et al. Tattoo allergy — diagnosis on a circuitous route? Allergo Journal International. 2024;33(88).

42. Serup J. et al. Tattoo Complaints and Complications: Diagnosis and Clinical Spectrum. Current problems in dermatology. 2015;48:48– 60.

43. Jungmann S. et al. From the Tattoo Studio to the Emergency Room. Dtsch. Arztebl. Int. 2016;113(40):672–675.

44. Lebhar J. et al. Skin cancers arising within tattoos: A systematic review. JAAD International. 2024;16:133–143.

45. Kluger N. et al. Keratoacanthomas and Squamous Cell Carcinomas on Tattoos: A Review of 42 Cases. Dermatology. 2021;237(2):309– 312.

46. Kluger N. et al. Tattoos, inks, and cancer. Lancet Oncol. 2012.13:e161–8.

47. Swigost A., Farah R.S., Canova E., Goldfarb N. Multiple squamous neoplasms arising in a red tattoo after laser tattoo removal. Dermatol. Surg. 2020;46(7):970–973.

48. Verdaguer-Faja J. et al. “A Strange Flower in the Garden”: The Importance of the Dermatoscope in the Assessment of Tattoos. Dermatol. Pract. Concept. 2024.1;14(1):e2024011.

49. Leijs M. et al. Cutaneous malignancies in tattoos, a case series of six patients. Curr. Oncol. 2021;28(6):4721–3477.

50. Latoni D.I. et al. Multiple de novo spitzoid nevi arising within a specifi c red tattoo ink. JAAD Case Rep. 2024;29;46:78–80.

51. Høgsberg T. et al. High prevalence of minor symptoms in tattoos among a young population tattooed with carbon black and organic pigments. Eur. Acad. Dermatol. Venereol. 2013;27(7):846–52.

52. Morte P.D. et al. Hyperalgesia after volar wrist tattoo: a case of complex regional pain syndrome? J. Clin. Neuromuscul. Dis. 2011;12:118–21.

53. Kluger N. et al. Keloid occurring in a tattoo. Ann. Dermatol. Venereol. 2017144:455.

54. Hutton Carlsen K. et al. Patients with tattoo reactions have reduced quality of life and suff er from itch. Skin Research and Technology. 2014;21(1),101–107.

55. Tope W.D. et al. Magnetic resonance imaging and permanent cosmetics (tattoos): survey of complications and adverse events. J. Magn. Reson. Imaging. 2002;15:180–4.

56. Shinohara M.M. et al. The histopathologic spectrum of decorative tattoo complications. J. Cutan. Pathol. 2012;39:1110–1118.

57. Wenzel S.M. et al. Adverse reactions after tattooing: Review of the literature and comparison to results of a survey. Dermatology.2013;226:138–147.

58. Charuta A. et al. of colourants used in tattoo and permanent make-up techniques, legal regulations, health, and psychological aspects of tattooing. Health Sci Rep.2023.8;6(9):e1360.

59. Kayumova M.M. и соавт. Epidemiological aspects of the prevalence of coronary heart disease in an open urban population: gender diff erences. Siberian Medical Journal. 2019;34(2):146–151. (In Russian).

60. Bagot M. Complications des tatouages: classifi cation clinique, histologique, physiopathologique, cinétique des particules. Bull. Acad. Natl. Med. 2020;204(6):607–610.

61. Kluger N. Acute complications of tattooing presenting in the ED. Am. J. Emerg. Med. 2012;30(9):2055–63.

62. Laumann A.E. et al. Tattoos and body piercings in the United States: a national data set. J. Am. Acad. Dermatol. 2006;55(3):413–21.

63. Drage L.A. et al. An outbreak of Mycobacterium chelonae infections in tattoos. J. Am. Acad. Dermatol. 2010;62:501–506.

64. Engel E. et al. Modern tattoos cause high concentrations of hazardous pigments in skin. Contact Dermat. 2008;58:228–233.

65. Anderson L.L. et al. Tattoo pigment mimicking metastatic malignant melanoma. Dermatol. Surg. 1996;22:92–94.

66. Karymov O.N. и соавт. Morphofunctional changes in the skin and lymph nodes in response to the introduction of tattoo pigment: an experimental study. Clinical Dermatology and Venereology. 2019;18(4):491–500. (In Russian).

67. Balasubramanian I. et al. Painful, pigmented lymphadenopathy secondary to decorative tattooing. Am. J. Emerg. Med. 2013;31:1001;e1–e2.

68. Prantsidis A. et al. Unusual mercury poisoning from tattoo dye. Hippokratia. 2017;21(4):197–200.

69. Schreiver I. et al. At the dark end of the rainbow: data gaps in tattoo toxicology. Arch. Toxicol. 2016;90(7):1763–5.

70. Voytsekhovsky V.V. Lymphadenopathies in clinical practice. Amur Medical Journal. 2017;1(17):8–19. (In Russian).

71. Vorobyov A.I. Manual of haematology. Edition of the third in 3 vol. 2. Moscow: Newdiamed, 2003:277. (In Russian).

72. Melikyan A.L. Algorithms of diagnostics of lymphadenopathies. Programme treatment of blood system diseases. Edited by V.G. Savchenko. Moscow: Publishing House ‘Praktika’. 2012:417–451. (In Russian).

73. Frizzera G., Seo I.S. Histopathology of non-malignant lymphadenopathies. Benign and malignant Lymphadenopathies. Eds. G Panglis, A Pollack. Chur: Harwood Academic Publishers, 1993:242–247

74. Feinstein A.R. Pre-therapeutic classifi cation of co-morbidity in chronic disease. Journal Chronic Disease. 1970;23(7):455–468.

75. Bălăceanu-Gurău B. et al. Cutaneous Adverse Reactions Associated with Tattoos and Permanent Makeup Pigments. J. Clin. Med. 2024.16;13(2):503.

76. Trushina E.V. и соавт. Competence of medical university community in the risks and consequences of skin tattooing according to the results of online questionnaire. Vestnik RSMU. 2016;3:70–76. (In Russian).


Review

For citations:


Krainyukov P.E., Simonenko V.B., Sarmanaev S.Kh., Shikhta N.A., Shikhta E.A., Dulin P.A. Medical consequences of tattoos. Clinical Medicine (Russian Journal). 2025;103(6):426-433. (In Russ.) https://doi.org/10.30629/0023-2149-2025-103-6-426-433

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ISSN 2412-1339 (Online)