clinmedКлиническая медицинаClinical Medicine (Russian Journal)0023-21492412-1339ООО «Медицинское информационное агентство»10.30629/0023-2149-2024-102-11-12-862-867clinmed-988Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL INVESTIGATIONSВнутрисосудистая активность тромбоцитов у пациентов с фибрилляцией предсердий на фоне приема прямых антикоагулянтовIntravascular platelet activity in patients with atrial fibrillation while taking direct anticoagulantshttps://orcid.org/0000-0002-7811-1371БобылеваТ. А.BobylevaT. A.

Бобылева Татьяна Александровна ― канд. мед. наук, доцент кафедры клинической физиологии и функциональной диагностики ФГБОУ ДПО РМАНПО Минздрава России; доцент кафедры терапии неотложных состояний Филиала ФГБВОУ ВО «Военно-медицинская академия им. С.М. Кирова» в г. Москве Минобороны России

Москва

Tatyana A. Bobyleva ― Candidate of Medical Sciences, Associate Professor of the Department of Clinical Physiology and Functional Diagnostics of the Russian Medical Academy of Continuous Professional Education of the Ministry of Health of Russia; Associate Professor of the Department of Emergency Medicine of the Military Medical Academy named after S.M. Kirov (Moscow branch) of the Ministry of Defense of Russia

Moscow

medicina51@mail.ruТкаченкоС. Б.ТkachenkoS. B.

Ткаченко Сергей Борисович ― д-р мед. наук, профессор, член-корр. РАН, заведующий кафедрой клинической физиологии и функциональной диагностики ФГБОУ ДПО РМАНПО Минздрава России

Москва

Sergey B. Tkachenko — Doctor of Medical Sciences, Professor, corresponding member of RAS, Chief of the Department of Clinical Physiology and Functional Diagnostics of the Russian Medical Academy of Continuous Professional Education of the Ministry of Health of Russia

Moscow

ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России; Филиал ФГБВОУ ВО «Военно-медицинская академия им. С.М. Кирова» в г. Москве Минобороны РоссииРоссияRussian Medical Academy of Continuous Professional Education of the Ministry of Health of Russia; Military Medical Academy named after S.M. Kirov (Moscow branch) of the Ministry of Defense of RussiaRussian FederationФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииРоссияRussian Medical Academy of Continuous Professional Education of the Ministry of Health of RussiaRussian Federation20241003202510211-12862867Copyright © Бобылева Т.А., Ткаченко С.Б., 20252025Бобылева Т.А., Ткаченко С.Б.Bobyleva T.A., Тkachenko S.B.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.clinmedjournal.com/jour/article/view/988

В статье представлен анализ изменений тромбоциторного звена системы гемостаза у пациентов с пароксизмальной и персистирующей формами фибрилляции предсердий на фоне приема прямых пероральных антикоагулянтов. Данная группа препаратов используется для профилактики ишемического инсульта и других системных тромбоэмболий. Число тромбоцитов, вовлеченных в агрегаты, было в пределах нормы, однако имеется тенденция к повышению активных форм тромбоцитов у данных пациентов.

The article presents an analysis of changes in the platelet component of the hemostatic system in patients with paroxysmal and persistent forms of atrial fibrillation while taking direct oral anticoagulants. This group of medications is used for the prevention of ischemic stroke and other systemic thromboembolic events. The number of platelets involved in aggregates was within normal limits; however, there is a tendency toward an increase in active forms of platelets in these patients.

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The authors declare that there are no conflicts of interest present.