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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">clinmed</journal-id><journal-title-group><journal-title xml:lang="ru">Клиническая медицина</journal-title><trans-title-group xml:lang="en"><trans-title>Clinical Medicine (Russian Journal)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0023-2149</issn><issn pub-type="epub">2412-1339</issn><publisher><publisher-name>ООО «Медицинское информационное агентство»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.30629/0023-2149-2024-102-9-10-767-771</article-id><article-id custom-type="elpub" pub-id-type="custom">clinmed-956</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЗАМЕТКИ И НАБЛЮДЕНИЯ ИЗ ПРАКТИКИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>NOTES AND OBSERVATIONS FROM PRACTICE</subject></subj-group></article-categories><title-group><article-title>Редкий случай эндокардит-опосредованной железодефицитной анемии</article-title><trans-title-group xml:lang="en"><trans-title>Rare case of endocarditis-induced iron deficiency anemia</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0008-6940-1861</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Цехомский</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Tsekhomsky</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Цехомский Александр Вячеславович — студент 4-го курса</p><p>Краснодар</p></bio><bio xml:lang="en"><p>Aleksandr V. Tsekhomsky — 4th year student</p><p>Krasnodar</p></bio><email xlink:type="simple">aastartov12@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Кубанский государственный медицинский университет» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kuban State Medical University of the Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>06</day><month>02</month><year>2025</year></pub-date><volume>102</volume><issue>9-10</issue><elocation-id>767–771</elocation-id><permissions><copyright-statement>Copyright &amp;#x00A9; Цехомский А.В., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Цехомский А.В.</copyright-holder><copyright-holder xml:lang="en">Tsekhomsky A.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.clinmedjournal.com/jour/article/view/956">https://www.clinmedjournal.com/jour/article/view/956</self-uri><abstract><p>Клинический случай подчеркивает значимость проблемы железодефицитной анемии (ЖДА) у пациентов с бактериальным эндокардитом (БЭ) и необходимость детального изучения связей между этими заболеваниями.</p><sec><title>Цель работы</title><p>Цель работы: исследование корреляции между БЭ и ЖДА, а также выяснение причинно-следственных связей между этими заболеваниями.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. Исследование основано на изучении клинического случая пациента с БЭ и ЖДА, пролеченного в НИИ ККБ № 1 г. Краснодара, включая анализ эффективности инфузий препаратов железа и других методов лечения.</p></sec><sec><title>Результаты</title><p>Результаты. Обнаружена связь между бактериемией, вызванной Rothia mucilaginosa, и развитием ЖДА. Также обсуждается взаимосвязь между трофическим иммунитетом и дефицитом железа.</p></sec><sec><title>Выводы</title><p>Выводы. Исследование подтверждает гипотезу о важной роли Rothia mucilaginosa в развитии эндокардита на аортальном протезе и в возникновении ЖДА. Выдвинуты предположения о механизмах потребления железа этим микроорганизмом и его влиянии на развитие железодефицитных состояний, что требует дальнейших исследований в данной области. </p></sec></abstract><trans-abstract xml:lang="en"><p>This clinical case highlights the significance of the problem of iron deficiency anemia (IDA) in patients with bacterial endocarditis (BE) and the necessity for a detailed study of the relationships between these diseases.</p><sec><title>Objective</title><p>Objective: To investigate the correlation between BE and IDA, as well as to clarify the causal relationships between these conditions. Materials and</p></sec><sec><title>Methods</title><p>Methods. The study is based on the examination of a clinical case of a patient with BE and IDA, treated at the Research Institute of Clinical Cardiology No. 1 in Krasnodar, including an analysis of the effectiveness of iron infusion therapies and other treatment methods.</p></sec><sec><title>Results</title><p>Results. A connection was found between bacteremia caused by Rothia mucilaginosa and the development of IDA. The relationship between trophic immunity and iron deficiency is also discussed.</p></sec><sec><title>Conclusions</title><p>Conclusions. The study confirms the hypothesis regarding the important role of Rothia mucilaginosa in the development of endocarditis on an aortic prosthesis and in the onset of IDA. Suggestions are made regarding the mechanisms of iron consumption by this microorganism and its influence on the development of iron deficiency states, which requires further research in this area.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>бактериальный эндокардит</kwd><kwd>железодефицитная анемия</kwd><kwd>анемия хронических болезней</kwd></kwd-group><kwd-group xml:lang="en"><kwd>bacterial endocarditis</kwd><kwd>iron deficiency anemia</kwd><kwd>anemia of chronic disease</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Борисова О. Ю., Алешкин В. А., Каргальцева Н. М., Кочеровец В. И., Пастушенков В. Л., Карпова Е. И., Данищук О. И., Афанасьев С. С. Первый случай выделения в России Rothia mucilaginosa из крови пациентки с осложнением после контурной пластики. Медицинский альманах. 2015;5(40). URL: https://cyberleninka.ru/article/n/pervyy-sluchay-vydeleniya-vrossii-rothia-mucilaginosa-iz-krovi-patsientki-s-oslozhneniemposle-konturnoy-plastiki (дата обращения: 22.02.2024).</mixed-citation><mixed-citation xml:lang="en">Borisova O.Yu., Aleshkin V.A., Kargaltseva N.M., Kocherovets V.I., Pastushenkov V.L., Karpova E.I., Danischuk O.I., Afanasyev S.S. The fi rst case of Rothia mucilaginosa isolated from the blood of a patient with complications after contour plastic surgery in Russia. Medical Almanac. 2015;5(40). [ Electronic resource]. URL: https:// cyberleninka.ru/article/n/pervyy-sluchay-vydeleniya-v-rossii-rothiamucilaginosa-iz-krovi-patsientki-s-oslozhneniem-posle-konturnoyplastiki (accessed: February 22, 2024). (In Russian)].</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Ascher D.P., Zbick C., White C., Fischer G.W. Infections due to Stomatococcus mucilaginosus: 10 cases and review. Rev. Infect. Dis. 1991;13:1048–1052.</mixed-citation><mixed-citation xml:lang="en">Ascher D.P., Zbick C., White C., Fischer G.W. Infections due to Stomatococcus mucilaginosus: 10 cases and review. Rev. Infect. Dis. 1991;13:1048–1052.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Trevirio V., Garcia-Zabarte A., Quintas A. et al. Stomatococcus mucilaginosus septicemia in a patient with acutelymphoblastic leukaemia. Eur. J. Clin. Microbiol. Infect. Dis. 1998;17:505–507.</mixed-citation><mixed-citation xml:lang="en">Trevirio V., Garcia-Zabarte A., Quintas A. et al. Stomatococcus mucilaginosus septicemia in a patient with acutelymphoblastic leukaemia. Eur. J. Clin. Microbiol. Infect. Dis. 1998;17:505–507.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Korsholm T.L., Haahr V., Prag J. Eight cases of lower respiratory tract infection caused by Stomatococcus mucilaginosus. Scand. J. Infect. Dis. 2007;39:913–917.</mixed-citation><mixed-citation xml:lang="en">Korsholm T.L., Haahr V., Prag J. Eight cases of lower respiratory tract infection caused by Stomatococcus mucilaginosus. Scand. J. Infect. Dis. 2007;39:913–917.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Sanchez-Carrillo C., Cercenado E., Cibrian F., Bouza E. Stomatococcus mucilaginosus pneumonia in a livertransplant patient. Clin. Microbiol. Newsl. 1995;16:150–151.</mixed-citation><mixed-citation xml:lang="en">Sanchez-Carrillo C., Cercenado E., Cibrian F., Bouza E. Stomatococcus mucilaginosus pneumonia in a livertransplant patient. Clin. Microbiol. Newsl. 1995;16:150–151.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Bruminhent J., Tokarczyk M.J., Jungkind D., Desimone J.A. Rothia mucilaginosa prosthetic device infections: a case of oristhetic valve endocarditis. J.Clin. Microbiol. 2013;51 (5):1629–1632.</mixed-citation><mixed-citation xml:lang="en">Bruminhent J., Tokarczyk M.J., Jungkind D., Desimone J.A. Rothia mucilaginosa prosthetic device infections: a case of oristhetic valve endocarditis. J.Clin. Microbiol. 2013;51 (5):1629–1632.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Mitchell P.S., Huston B.J., Jones R.N., Holcomb L., Koontz F.P. Stomatococcus mucilaginosus bacteraemias: typical case presentations, simplified diagnostic criteria, and a literature review. Diagn. Microbiol. Infect. Dis. 1990;13:521–525.</mixed-citation><mixed-citation xml:lang="en">Mitchell P.S., Huston B.J., Jones R.N., Holcomb L., Koontz F.P. Stomatococcus mucilaginosus bacteraemias: typical case presentations, simplifi ed diagnostic criteria, and a literature review. Diagn. Microbiol. Infect. Dis. 1990;13:521–525.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Верткин А. Л. Анемия: Руководство для практических врачей. Верткин А.Л., Ховасова Н.О., Ларюшкина Е.Д., Шамаева К.И. Москва: Эксмо, 2014:144.</mixed-citation><mixed-citation xml:lang="en">Vertkin A.L. Anemia: A Guide for Practicing Physicians. Vertkin A.L., Khovasova N.O., Laryushkina E.D., Shamaeva K.I. Moscow: Eksmo, 2014:144. (In Russian)].</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Becker K.W., Skaar E.P. Metal limitation and toxicity at the interface between host and pathogen. FEMS Microbiol. Rev. 2014;38(6):1235–1249. DOI: 10.1111/1574-6976.12087</mixed-citation><mixed-citation xml:lang="en">Becker K.W., Skaar E.P. Metal limitation and toxicity at the interface between host and pathogen. FEMS Microbiol. Rev. 2014;38(6):1235–1249. DOI: 10.1111/1574-6976.12087</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Weiss G., Carver P.L. Role of divalent metals in infectious disease susceptibility and outcome. Clin. Microbiol. Infect. 2018;24(1):16–23. DOI: 10.1016/j.cmi.2017.01.018</mixed-citation><mixed-citation xml:lang="en">Weiss G., Carver P.L. Role of divalent metals in infectious disease susceptibility and outcome. Clin. Microbiol. Infect. 2018;24(1):16–23. DOI: 10.1016/j.cmi.2017.01.018</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Agranoff D., Krishna S. Metal ion transport and regulation in Mycobacterium tuberculosis. Front. Biosci. 2004;9:2996–3006.</mixed-citation><mixed-citation xml:lang="en">Agranoff  D., Krishna S. Metal ion transport and regulation in Mycobacterium tuberculosis. Front. Biosci. 2004;9:2996–3006.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Schmitt M.P., Holmes R.K. Iron-dependent regulation of diphtheria toxin and siderophore expression by the cloned Corynebacterium diphtheriae repressor gene dtxR in C. diphtheriae C7 strains. Infect. Immun. 1991;59(6):1899–1904.</mixed-citation><mixed-citation xml:lang="en">Schmitt M.P., Holmes R.K. Iron-dependent regulation of diphtheria toxin and siderophore expression by the cloned Corynebacterium diphtheriae repressor gene dtxR in C. diphtheriae C7 strains. Infect. Immun. 1991;59(6):1899–1904.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Torres V.J., Attia A.S., Mason W.J, et al. Staphylococcus aureus fur regulates the expression of virulence factors that contribute to the pathogenesis of pneumonia. Infect. Immun. 2010;78(4):1618–1628. DOI: 10.1128/IAI.01423-09</mixed-citation><mixed-citation xml:lang="en">Torres V.J., Attia A.S., Mason W.J, et al. Staphylococcus aureus fur regulates the expression of virulence factors that contribute to the pathogenesis of pneumonia. Infect. Immun. 2010;78(4):1618–1628. DOI: 10.1128/IAI.01423-09</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Mazmanian S.K., Skaar E.P., Gaspar A.H., et al. Passage of hemeiron across the envelope of Staphylococcus aureus. Science. 2003;299(5608):906–909.</mixed-citation><mixed-citation xml:lang="en">Mazmanian S.K., Skaar E.P., Gaspar A.H., et al. Passage of hemeiron across the envelope of Staphylococcus aureus. Science. 2003;299(5608):906–909.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Орлов Ю.П., Говорова Н.В., Лукач В.Н., Байтугаева Г.А., Клементьев А.В., Какуля Е.Н. Метаболизм железа в условиях инфекции. Обзор литературы. Вестник интенсивной терапии имени А.И. Салтанова. 2021;(1):90–99. DOI:10.21320/1818-474X-2020-1-90-99</mixed-citation><mixed-citation xml:lang="en">Orlov Y.P., Govorova N.V., Lukach V.N., Baitugaeva G.A., Klementiev A.V., Kakulia E.N. Iron metabolism under infection conditions. A literature review. Bulletin of Intensive Care Named after A.I. Saltanov. 2021;(1):90–99. (In Russian)]. DOI:10.21320/1818-474X-2020-1-90-99</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Орлов Ю.П., Долгих В.Т., Глущенко А.В. Может ли свободный гемоглобин быть маркером тяжести общего состояния при сепсисе? Вестник интенсивной терапии имени А.И. Салтанова. 2018;1:48–54</mixed-citation><mixed-citation xml:lang="en">Орлов Ю.П., Долгих В.Т., Глущенко А.В. Может ли свободный гемоглобин быть маркером тяжести общего состояния при сепсисе? Вестник интенсивной терапии имени А.И. Салтанова. 2018;1:48–54. [Orlov Yu.P., Dolgih V.T., Gluschenko A.V. Mozhet li svobodnyiy gemoglobin byit markerom tyazhesti obschego sostoyaniya pri sepsise? Vestnik intensivnoy terapii imeni A.I. Saltanova. 2018;1;48–54. (In Russian)].</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Toom S, Xu Y. Hemolytic anemia due to native valve subacute endocarditis with Actinomyces israelii infection. Clin. Case Rep. 2018;6(2):376–379. DOI: 10.1002/ccr3.1333. PMID: 29445480; PMCID: PMC5799637.</mixed-citation><mixed-citation xml:lang="en">Toom S, Xu Y. Hemolytic anemia due to native valve subacute endocarditis with Actinomyces israelii infection. Clin. Case Rep. 2018;6(2):376–379. DOI: 10.1002/ccr3.1333. PMID: 29445480; PMCID: PMC5799637.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Soumik Ghosh, Ratnakar Sahoo, Ranjit Kumar Nath, Nandini Duggal, and Adesh Kumar Gadpayle. A Study of Clinical, Microbiological, and Echocardiographic Profile of Patients of Infective Endocarditis. Hindawi Publishing Corporation. International Scholarly Research Notices. 2014:340601. DOI: 10.1155/2014/340601</mixed-citation><mixed-citation xml:lang="en">Soumik Ghosh, Ratnakar Sahoo, Ranjit Kumar Nath, Nandini Duggal, and Adesh Kumar Gadpayle. A Study of Clinical, Microbiological, and Echocardiographic Profi le of Patients of Infective Endocarditis. Hindawi Publishing Corporation. International Scholarly Research Notices. 2014:340601. DOI: 10.1155/2014/340601</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Sivakumar R., Ghosh P., Khan S.A., Infective endocarditis in older people, Age and Ageing, 2003;32(1):116, DOI: 10.1093/ageing/32.1.116</mixed-citation><mixed-citation xml:lang="en">Sivakumar R., Ghosh P., Khan S.A., Infective endocarditis in older people, Age and Ageing, 2003;32(1):116, DOI: 10.1093/ageing/32.1.116</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Masamichi Koike, MD, Takahiro Doi, MD, Koki Morishita, Kosuke Uruno, Mirei Kawasaki-Nabuchi, Kaoru Komuro, Hiroyuki Iwano, Syuichi Naraoka, Daigo Nagahara, Satoshi Yuda, Impact of Hemoglobin Level, White Blood Cell Count, Renal Dysfunction, and Staphylococcus as the Causative Organism on Prediction of In-Hospital Mortality from Infective Endocarditis, Received for publication July 13, 2023. Revised and accepted January 22, 2024. Int. Heart J. 2024;65(2):199–210. DOI: 10.1536/ihj.23-360</mixed-citation><mixed-citation xml:lang="en">Masamichi Koike, MD, Takahiro Doi, MD, Koki Morishita, Kosuke Uruno, Mirei Kawasaki-Nabuchi, Kaoru Komuro, Hiroyuki Iwano, Syuichi Naraoka, Daigo Nagahara, Satoshi Yuda, Impact of Hemoglobin Level, White Blood Cell Count, Renal Dysfunction, and Staphylococcus as the Causative Organism on Prediction of In-Hospital Mortality from Infective Endocarditis, Received for publication July 13, 2023. Revised and accepted January 22, 2024. Int. Heart J. 2024;65(2):199–210. DOI: 10.1536/ihj.23-360</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
