clinmedКлиническая медицинаClinical Medicine (Russian Journal)0023-21492412-1339ООО «Медицинское информационное агентство»10.30629/0023-2149-2024-102-5-6-427-432clinmed-861Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL INVESTIGATIONSКачество жизни как отражение метаболических показателей у пациентов, находящихся на программном гемодиализеQuality of life as a reflection of metabolic indicators in patients undergoing programmed hemodialysishttps://orcid.org/0000-0002-0395-7946ИевлевЕ. Н.IevlevE. N.

Иевлев Евгений Николаевич — канд. мед. наук, доцент кафедры внутренних болезней с курсами лучевых методов диагностики и лечения, военно-полевой терапии

Ижевск

Evgeny N. Ievlev — Candidate of Medical Sciences, Associate Professor of the Department of Internal Diseases with courses of Radiation Methods of Diagnosis and Treatment, and Military Field Therapy

Izhevsk

inloja@mail.ruhttps://orcid.org/0000-0001-7815-1536КазаковаИ. А.KazakovaI. A.

Казакова Ирина Александровна — д-р мед. наук, профессор, зав. кафедрой внутренних болезней с курсами лучевых методов диагностики и лечения, военно-полевой терапии

Ижевск

Irina A. Kazakova — MD, PhD, DSc, Professor, Head of the Department of Internal Diseases with courses of Radiation Methods of Diagnosis and Treatment, and Military Field Therapy

Izhevsk

ФГБОУ ВО «Ижевская государственная медицинская академия» Минздрава России; БУЗ УР «Городская клиническая больница №6» Минздрава УдмуртииРоссияIzhevsk State Medical Academy of the Ministry of Healthcare of Russia; City Clinical Hospital No. 6 of Healthcare of Udmurt RepublicRussian FederationФГБОУ ВО «Ижевская государственная медицинская академия» Минздрава РоссииРоссияIzhevsk State Medical Academy of the Ministry of Healthcare of RussiaRussian Federation2024081120241025-6427432Copyright © Иевлев Е.Н., Казакова И.А., 20242024Иевлев Е.Н., Казакова И.А.Ievlev E.N., Kazakova I.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.clinmedjournal.com/jour/article/view/861

Метаболические нарушения, связанные с хронической болезнью почек (ХБП), могут приводить к снижению качества жизни пациента, находящегося на гемодиализе. Цель работы. Проанализировать связь качества жизни (КЖ) гемодиализных пациентов с клинико-лабораторными показателями. Материал и методы. Обследован 251 пациент с ХБП 5-й стадии. М/Ж = 108/143. Средний возраст составил 54,4 ± 9,9 года. Все пациенты заполняли специфический опросник КЖ KDQOL-SF™. Результаты. Опрашиваемых пациентов больше беспокоили симптомы: слабость, головокружение, мышечная боль (U = 765; p < 0,001), коррелировавшие с альбумином (R = 0,5; p < 0,01), кальций- фосфорным произведением (R = −0,48; p < 0,01). Также беспокоили невозможность путешествовать и необходимость соблюдать диету (U = 553; p < 0,001), коррелировавшие с частотой сердечных сокращений (R = −0,51; p < 0,001) и уровнем калия (R = −0,59; p < 0,001). Обремененность ХБП имела связь с уровнем триглицеридов (R = 0,36; p < 0,01). Трудоспособность связана с возрастом (R = −0,54; p < 0,001), eKT/V (R = 0,47; p < 0,01). Показатели когнитивной функции коррелировали с уровнем артериального давления (АД) (R = −0,51; p < 0,001), пульсовым давлением (R = −0,55; p < 0,001). Сексуальные функции связаны с АД (R = −0,64; p < 0,001), уровнем кальция (R = −0,76; p < 0,001), железа (R = −0,42; p < 0,01), коэффициентом насыщения трансферина (R = −0,51; p < 0,001). Качество сна связано с кальций-фосфорным произведением (R = −0,51; p < 0,001). Ощущение социальной поддержки коррелировало с содержанием магния (R = −0,59; p < 0,001), кальция (R = −0,51; p < 0,001). Выводы. Выявлены корреляции качества жизни с АД, альбумином и кальций-фосфорным обменом, обменом железа.

Metabolic disorders associated with chronic kidney disease (CKD) can lead to a decrease in the quality of life of patients on hemodialysis. The aim of this study is to analyze the correlation between quality of life (QOL) in patients receiving treatment with PHD and clinical and laboratory indicators. Material and methods. 251 patients with stage 5 CKD were included in the study. There were 108 men and 143 women. The mean age was 54.4 ± 9.9 years. All participants completed a specific quality of life questionnaire KDQOL-SF. Results. The interviewed patients reported more concern about symptoms such as weakness, dizziness, and muscle pain (U = 765, p < 0.001), which was correlated with albumin levels (R = 0.5, p < 0.01) and calcium-phosphorus product levels (R = –0.48, p < 0.05). They also expressed concern about the inability to travel or follow a special diet (U = 553, p < 0.005), which correlated with heart rate levels (R = –0.51, P < 0.1) and serum potassium levels (R = –0.6, P < 0.1). Additionally, the burden of CKD correlated with triglycerides (R = 0.36, p = 0,01).Work capacity is associated with age (R = –0.54; p < 0.001), eKT/V (R = 0.47; p < 0.01). Indicators of cognitive function correlate with blood pressure (BP) (R = –0.51, p < 0,001) and pulse pressure (P = –0,55, p < 0,01). Sexual functions are associated with BP (R = –0,64, p < 0,05), calcium levels (R = 0,76, p > 0.80), iron (0,42, p = 0,90), transferrin saturation coefficient (0.5, p = 0.91). Sleep quality correlates with calcium-phosphate production (0.3, p > 0.15). The feeling of social support correlates with magnesium (0,3, P > 0,8), calcium (0.2, P > 0,1). Conclusions. Correlations between quality of life, blood pressure, albumin, and calcium phosphate metabolism, iron, were found.

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The authors declare that there are no conflicts of interest present.