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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">clinmed</journal-id><journal-title-group><journal-title xml:lang="ru">Клиническая медицина</journal-title><trans-title-group xml:lang="en"><trans-title>Clinical Medicine (Russian Journal)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0023-2149</issn><issn pub-type="epub">2412-1339</issn><publisher><publisher-name>ООО «Медицинское информационное агентство»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.30629/0023-2149-2024-102-4-360-366</article-id><article-id custom-type="elpub" pub-id-type="custom">clinmed-819</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>В ПОМОЩЬ ПРАКТИЧЕСКОМУ ВРАЧУ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>GUIDELINES FOR PRACTITIONERS</subject></subj-group></article-categories><title-group><article-title>Диагностика и лечение острого аппендицита у пациентов с новой короновирусной инфекцией COVID-19</article-title><trans-title-group xml:lang="en"><trans-title>Diagnosis and treatment of acute appendicitis in patients with the new coronavirus infection COVID-19</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5256-3548</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Каверина</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kaverina</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Каверина Анна Александровна — ассистент кафедры общей и клинической хирургии</p><p>Хабаровск</p></bio><bio xml:lang="en"><p>Anna A. Kaverina — assistant at the Department of General and Clinical Surgery</p><p>Khabarovsk</p></bio><email xlink:type="simple">anna.kaverina.1981@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4118-8746</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Вавринчук</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Vavrinchuk</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Вавринчук Сергей Андреевич — д-р мед. наук, профессор кафедры общей и клинической хирургии</p><p>Хабаровск</p></bio><bio xml:lang="en"><p>Sergey A. Vavrinchuk — Dr . of Sci. (Med.), Professor of the Department of General and Clinical Surgery</p><p>Khabarovsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6014-7149</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Косенко</surname><given-names>П. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Kosenko</surname><given-names>P. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Косенко Павел Михайлович — д-р мед. наук, профессор кафедры общей и клинической хирургии</p><p>Хабаровск</p></bio><bio xml:lang="en"><p>Pavel M. Kosenko — Dr . of Sci. (Med.), Professor of the Department of General and Clinical Surgery</p><p>Khabarovsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Дальневосточный государственный медицинский университет»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Far Eastern State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>25</day><month>07</month><year>2024</year></pub-date><volume>102</volume><issue>4</issue><fpage>360</fpage><lpage>366</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Каверина А.А., Вавринчук С.А., Косенко П.М., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Каверина А.А., Вавринчук С.А., Косенко П.М.</copyright-holder><copyright-holder xml:lang="en">Kaverina A.A., Vavrinchuk S.A., Kosenko P.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.clinmedjournal.com/jour/article/view/819">https://www.clinmedjournal.com/jour/article/view/819</self-uri><abstract><p>Работа посвящена особенностям клиники, диагностики и лечения острого аппендицита (ОА) у пациентов с новой короновирусной инфекцией (НКИ) COVID-19. Проведен анализ 73 случаев диагностики и лечения ОА у пациентов с COVID-19 в инфекционном стационаре. У пациентов с COVID-19 иммунопатологические реакции, нарушения сознания, проводимая антибактериальная и противовоспалительная терапия затрудняли диагностику сочетанного ОА, приводя к сглаженности или полному отсутствию местных болевых симптомов, к невозможности полноценного сбора жалоб и анамнеза заболевания, обуславливали наличие лейкопении. У пациентов с тяжелым течением COVID-19 с нарушениями сознания по шкале комы Глазго до 9–13 баллов, КТ4 степени и дыхательной недостаточностью 3-й степени основанием для целенаправленного диагностического поиска острой хирургической патологии органов брюшной полости воспалительного характера являлось прогрессирующее нарастание лейкоцитоза в общем анализе крови, рефрактерного к проводимой антибактериальной и противовоспалительной терапии, в сочетании со значениями СРБ и прокальцитонина (ПКТ), превышающими их средние значения в группе пациентов с COVID-19. При нарастании степени тяжести COVID-19 окончательная диагностика ОА была возможна только при использовании дополнительных инструментальных методов диагностики и выполнении диагностических лапаротомий (лапароскопий). Выявлена прямая корреляционная связь между тяжестью течения COVID-19 и увеличением частоты гангренозных форм ОА и вторичного ОА. Количество послеоперационных осложнений при ОА находилось в прямой корреляционной зависимости от тяжести течения COVID-19. Летальные исходы были только у пациентов с тяжелым течением COVID-19 вследствие прогрессирования полиорганной недостаточности.</p></abstract><trans-abstract xml:lang="en"><p>The work is dedicated to the features of the clinic, diagnosis, and treatment of acute appendicitis (AA) in patients with the new coronavirus infection (COVID-19). An analysis of 73 cases of diagnosis and treatment of AA in patients with COVID-19 in an infectious diseases hospital was conducted. In patients with COVID-19, immunopathological reactions, disturbances of consciousness, and the administration of antibacterial and anti-inflammatory therapy complicated the diagnosis of concurrent AA, leading to a smoothing or complete absence of local pain symptoms, an inability to fully collect complaints and medical history, and the presence of leukopenia. In patients with severe COVID-19 with disturbances of consciousness according to the Glasgow Coma Scale up to 9–13 points, CT grade 4, and respiratory failure of the 3rd degree, the basis for targeted diagnostic search for acute surgical pathology of the abdominal cavity of an inflammatory nature was the progressive increase in leukocytosis in the complete blood count, refractory to the administered antibacterial and anti-inflammatory therapy, in combination with values of CRP and procalcitonin (PCT) exceeding their average values in the group of patients with COVID-19. With an increase in the severity of COVID-19, the final diagnosis of AA was possible only when using additional instrumental diagnostic methods and performing diagnostic laparotomies (laparoscopies). A direct correlation was found between the severity of COVID-19 and an increase in the frequency of gangrenous forms of AA and secondary AA. The number of postoperative complications in AA was directly correlated with the severity of COVID-19. Fatal outcomes occurred only in patients with severe COVID-19 due to the progression of multiorgan failure.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>острый аппендицит</kwd><kwd>новая коронавирусная инфекция COVID-19</kwd></kwd-group><kwd-group xml:lang="en"><kwd>acute appendicitis</kwd><kwd>new coronavirus infection COVID-19</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Téoule P., Laff olie J., Rolle U., Reissfelder C. Acute Appendicitis in Childhood and Adulthood. Dtsch. Arztebl. Int. 2020;117(45):764– 774. DOI: 10.3238/arztebl.2020.0764. PMID: 33533331; PMCID: PMC7898047</mixed-citation><mixed-citation xml:lang="en">Téoule P., Laff olie J., Rolle U., Reissfelder C. Acute Appendicitis in Childhood and Adulthood. Dtsch. Arztebl. Int. 2020;117(45):764– 774. 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