clinmedКлиническая медицинаClinical Medicine (Russian Journal)0023-21492412-1339ООО «Медицинское информационное агентство»10.30629/0023-2149-2024-102-2-109-117clinmed-759Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESПатофизиологические аспекты морфологических изменений створок атриовентрикулярных клапанов при сахарном диабетеPathophysiological aspects of morphological changes in the structure of atrioventricular valves leafl ets in diabetes mellitushttps://orcid.org/0000-0002-2706-3496КрыловВ. В.KrylovV. V.

Владислав Викторович Крылов, канд. мед. наук, врач — сердечно-сосудистый хирург

кардиохирургическое отделение для взрослых; отделение экстренной и плановой консультативной медицинской помощи

Москва

РИНЦ AuthorID: 979874

Vladislav V. Krylov, MD, Candidate of Medical Sciences, cardiovascular surgeon

Adults’ Cardiovascular Surgery Department; Emergency and Routine Counseling Department 

Moscow

РИНЦ AuthorID: 979874

malus5@yandex.ruhttps://orcid.org/0000-0002-4290-3182РагимовМ. Р.RagimovM. R.

Магомедкерим Разинович Рагимов, канд. мед. наук, врач-эндокринолог, научный сотрудник

отделение терапевтической эндокринологии

Москва

РИНЦ AuthorID: 967432

Magomedkerim R. Ragimov, MD, endocrinologist, Candidate of Medical Sciences, researcher

Department of Therapeutic Endocrinology

Moscow

РИНЦ AuthorID: 967432

https://orcid.org/0000-0003-1668-8711МисниковаИ. В.MisnikovaI. V.

Инна Владимировна Мисникова, д-р мед. наук, врач-эндокринолог, ведущий научный сотрудник, профессор

отделение терапевтической эндокринологии; кафедра эндокринологии с курсом частной эндокринологии

Москва

РИНЦ AuthorID: 559756

Inna V. Misnikova, MD, endocrinologist, Doctor of Medical Sciences, leading researcher, Professor

Department of Therapeutic Endocrinology; Department of Endocrinology with a course of particularistic endocrinology

Moscow

РИНЦ AuthorID: 559756

ГБУЗ МО «Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского»РоссияM.F. Vladimirsky Moscow Regional Research and Clinical Institute («MONIKI»)Russian Federation2024080520241022109117Copyright © Крылов В.В., Рагимов М.Р., Мисникова И.В., 20242024Крылов В.В., Рагимов М.Р., Мисникова И.В.Krylov V.V., Ragimov M.R., Misnikova I.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.clinmedjournal.com/jour/article/view/759

   Увеличение количества больных с сахарным диабетом в структуре коморбидных кардиохирургических пациентов диктует необходимость более подробного изучения патофизиологических механизмов модифицирующего влияния сахарного диабета с учетом новых научных данных и позволяет более системно взглянуть на процессы, ранее являвшиеся прерогативой узких специалистов.

   Содержание

   Содержание. Приведен современный взгляд на патофизиологические механизмы влияния сахарного диабета на сердечные структуры с описанием 2 наиболее значимых патологических синдромов — диабетической кардиомиопатии и изменения морфологической структуры створок атриовентрикулярных клапанов — и обоснованием расширения роли эндокринолога в обследовании и лечении кардиохирургических пациентов.

   Заключение

   Заключение. Системный взгляд на проблему сахарного диабета в кардиохирургии с внедрением мультидисциплинарного подхода и активным участием эндокринолога на всех этапах лечебного процесса позволит улучшить результаты лечения кардиохирургических пациентов и уменьшить сроки их послеоперационного восстановления.

   The increasing number of patients with diabetes in the structure of comorbid cardiothoracic patients necessitates a more detailed study of the pathophysiological mechanisms of the modifying infl uence of diabetes, taking into account new scientific data. This allows for a more systematic view of processes that were previously the prerogative of specialists.

   Content

   Content. A modern perspective on the pathophysiological mechanisms of diabetes on cardiac structures is presented, with a description of the two most signifi cant pathological syndromes — diabetic cardiomyopathy and changes in the morphological structure of the atrioventricular valve leafl ets. The expansion of the endocrinologist’s role in the examination and treatment of cardiothoracic patients is justifi ed.

   Conclusion

   Conclusion. A systemic approach to the problem of diabetes in cardiothoracic surgery, incorporating a multidisciplinary approach and active involvement of endocrinologists at all stages of the treatment process, will improve treatment outcomes for cardiothoracic patients and reduce their postoperative recovery times.

кардиохирургияэндокринологиясахарный диабетгипергликемиягиперинсулинемияинсулинорезистентностьдиабетическая кардиомиопатиябиомеханика атриовентрикулярных клапановмультидисциплинарный подходcardiothoracic surgeryendocrinologydiabeteshyperglycemiahyperinsulinemiainsulin resistancediabetic cardiomyopathybiomechanics of atrioventricular valvesmultidisciplinary approachИсследование не имело спонсорской поддержкиThe study had no sponsorshipReferencesГлущенко В.А., Ирклиенко Е.К. Сердечно-сосудистая заболеваемость — одна из важнейших проблем здравоохранения. Медицина и организация здравоохранения. 2019;4(1):56–63.Glushchenko V.A., Irklienko E.K. Cardiovascular morbidity is one of the most important public health problems. Meditsina i organizatsiia zdravookhraneniia. 2019;4(1):56–63. (In Russian)Robich M.P., Sellke F.W. Cardiac surgery and diabetes mellitus. In: Johnstone M., Veves A. (eds) Diabetes and Cardiovascular Disease. Contemporary Cardiology. Humana, Cham, 2023. DOI: 10.1007/978-3-031-13177-6_26Robich M.P., Sellke F.W. Cardiac surgery and diabetes mellitus. In: Johnstone M., Veves A. (eds) Diabetes and Cardiovascular Disease. Contemporary Cardiology. Humana, Cham, 2023. DOI: 10.1007/978-3-031-13177-6_26Sun H., Saeedi P., Karuranga S. et al. IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Research and Clinical Practice. 2022;183:109119. DOI: 10.1016/j.diabres.2021.109119Sun H., Saeedi P., Karuranga S. et al. IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Research and Clinical Practice. 2022;183:109119. DOI: 10.1016/j.diabres.2021.109119Дедов И.И., Шестакова М.В., Майоров А.Ю. и соавт. Алгоритмы специализированной медицинской помощи больным сахарным диабетом. Под редакцией И.И. Дедова, М.В. Шестаковой, А.Ю. Майорова. 11-й выпуск. Сахарный диабет. 2023;24(1S):1–148. doi: 10.14341/DM13042Dedov I.I., Shestakova M.V., Mayorov A.Yu. et al. Standards of specialized diabetes care. Edited by Dedov I.I., Shestakova M.V., Mayorov A.Yu. 11th ed. Diabetes mellitus. 2023;24(1S):1–148. (In Russian). doi: 10.14341/DM13042Jia G., Hill M.A., Sowers J.R. Diabetic cardiomyopathy: an update of mechanisms contributing to this clinical entity. Circulation Research. 2018;122(4):624–638. DOI: 10.1161/CIRCRESAHA.117.311586Jia G., Hill M.A., Sowers J.R. Diabetic cardiomyopathy: an update of mechanisms contributing to this clinical entity. Circulation Research. 2018;122(4):624–638. DOI: 10.1161/CIRCRESAHA.117.311586Hölscher M.E., Bode C., Bugger H. Diabetic Cardiomyopathy: Does the Type of Diabetes Matter? International Journal of Molecular Sciences. 2016;17(12):2136. DOI: 10.3390/ijms17122136Hölscher M.E., Bode C., Bugger H. Diabetic Cardiomyopathy: Does the Type of Diabetes Matter? International Journal of Molecular Sciences. 2016;17(12):2136. DOI: 10.3390/ijms17122136Labombarda F., Leport M., Morello R. et al. Longitudinal left ventricular strain impairment in type 1 diabetes children and adolescents: a 2D speckle strain imaging study. Diabetes & Metabolism. 2014;40(4):292–298. DOI: 10.1016/j.diabet.2014.03.007Labombarda F., Leport M., Morello R. et al. Longitudinal left ventricular strain impairment in type 1 diabetes children and adolescents: a 2D speckle strain imaging study. Diabetes & Metabolism. 2014;40(4):292–298. DOI: 10.1016/j.diabet.2014.03.007Lundbaek K. Diabetic angiopathy: a specifi c vascular disease. Lancet. 1954;266(6808):377–379. DOI: 10.1016/s0140-6736(54)90924-1Lundbaek K. Diabetic angiopathy: a specifi c vascular disease. Lancet. 1954;266(6808):377–379. DOI: 10.1016/s0140-6736(54)90924-1Rubler S., Dlugash J., Yuceoglu Y.Z. et al. New type of cardiomyopathy associated with diabetic glomerulosclerosis. The American Journal of Cardiology. 1972;30(6):595–602. DOI: 10.1016/0002-9149(72)90595-4Rubler S., Dlugash J., Yuceoglu Y.Z. et al. New type of cardiomyopathy associated with diabetic glomerulosclerosis. The American Journal of Cardiology. 1972;30(6):595–602. DOI: 10.1016/0002-9149(72)90595-4Караваев П.Г., Веклич А.С., Козиолова Н.А. Диабетическая кардиомиопатия: особенности сердечно-сосудистого ремоделирования. Российский кардиологический журнал. 2019;24(11):42–47. DOI: 10.15829/1560-4071-2019-11-42-47Karavaev P.G., Veklich A.S., Koziolova N.A. Cardiovascular remodeling in patients with diabetic сardiomyopathy. Russian Journal of Cardiology. 2019;24(11):42–47 . (In Russian). DOI: 10.15829/1560-4071-2019-11-42-47Козиолова Н.А., Караваев П.Г., Веклич А.С. Диабетическая кардиомиопатия: определение, критерии диагноза, направления терапии и предупреждения сердечной недостаточности. Южно-Российский журнал терапевтической практики. 2020;1(2):93–101. DOI: 10.21886/2712-8156-2020-1-2-93-101Koziolova N.A., Karavaev P.G., Veklich A.S. Diabetic cardiomyopathy: defi nition, diagnosis criteria, treatment directions and prevention of heart failure. South Russia Journal of Therapeutic Practices. 2020;1(2):93–101. (In Russian). DOI: 10.21886/2712-8156-2020-1-2-93-101Греков И.С., Грушина М.В. Метаболическая кардиомиопатия: современный взгляд на проблему. Университетская клиника. 2020;(37):139–140. DOI: 10.26435/uc.v0i4(37).440Grekov I.S., Grushina M.V. Metabolic cardiomyopathy: a modern view of the problem. University Clinic. 2020;(37):139–140. (In Russian). DOI: 10.26435/uc.v0i4(37).440Nakamura M., Sadoshima J. Cardiomyopathy in obesity, insulin resistance and diabetes. The Journal of Physiology. 2020;598(14):2977–2993. DOI: 10.1113/JP276747Nakamura M., Sadoshima J. Cardiomyopathy in obesity, insulin resistance and diabetes. The Journal of Physiology. 2020;598(14):2977–2993. DOI: 10.1113/JP276747Dillmann W.H. Diabetic Cardiomyopathy. Circulation Research. 2019;124(8):1160–1162. DOI: 10.1161/CIRCRESAHA.118.314665Dillmann W.H. Diabetic Cardiomyopathy. Circulation Research. 2019;124(8):1160–1162. DOI: 10.1161/CIRCRESAHA.118.314665Сваровская А.В., Гарганеева А.А. Сахарный диабет 2-го типа и сердечная недостаточность — современный взгляд на механизмы развития. Сахарный диабет. 2022;25(3):267–274. DOI: 10.14341/DM12648Svarovskaya A.V., Garganeeva A.A. Diabetes mellitus and heart failure — a modern look at the mechanisms of development. Diabetes mellitus. 2022;25(3):267–274. (In Russian). DOI: 10.14341/DM12648Lee W.S., Kim J. Diabetic cardiomyopathy: where we are and where we are going. The Korean Journal of Internal Medicine. 2017;32(3):404–421. DOI: 10.3904/kjim.2016.208Lee W.S., Kim J. Diabetic cardiomyopathy: where we are and where we are going. The Korean Journal of Internal Medicine. 2017;32(3):404–421. DOI: 10.3904/kjim.2016.208Sasso F.C., Rinaldi L., Lascar N. et al. Role of Tight Glycemic Control during Acute Coronary Syndrome on CV Outcome in Type 2 Diabetes. Journal of Diabetes Research. 2018:3106056. DOI: 10.1155/2018/3106056Sasso F.C., Rinaldi L., Lascar N. et al. Role of Tight Glycemic Control during Acute Coronary Syndrome on CV Outcome in Type 2 Diabetes. Journal of Diabetes Research. 2018:3106056. DOI: 10.1155/2018/3106056Bedi K.C. Jr, Snyder N.W., Brandimarto J. et al. Evidence for intramyocardial disruption of lipid metabolism and increased myocardial ketone utilization in advanced human heart failure. Circulation. 2016;133(8):706–716. DOI: 10.1161/CIRCULATIONAHA.115.017545Bedi K.C. Jr, Snyder N.W., Brandimarto J. et al. Evidence for intramyocardial disruption of lipid metabolism and increased myocardial ketone utilization in advanced human heart failure. Circulation. 2016;133(8):706–716. DOI: 10.1161/CIRCULATIONAHA.115.017545El Hayek M.S., Ernande L., Benitah J.-P. et al. The role of hyperglycaemia in the development of diabetic cardiomyopathy. Archives of Cardiovascular Diseases. 2021;114(11):748–760. DOI: 10.1016/j.acvd.2021.08.004El Hayek M.S., Ernande L., Benitah J.-P. et al. The role of hyperglycaemia in the development of diabetic cardiomyopathy. Archives of Cardiovascular Diseases. 2021;114(11):748–760. DOI: 10.1016/j.acvd.2021.08.004Evangelista I., Nuti R., Picchioni T. et al. Molecular dysfunction and phenotypic derangementin diabetic cardiomyopathy. International Journal of Molecular Sciences. 2019;20(13):3264. DOI: 10.3390/ijms20133264Evangelista I., Nuti R., Picchioni T. et al. Molecular dysfunction and phenotypic derangementin diabetic cardiomyopathy. International Journal of Molecular Sciences. 2019;20(13):3264. DOI: 10.3390/ijms20133264Salvatore T., Pafundi P.C., Galiero R. et al. The diabetic cardiomyopathy: the contributing pathophysiological mechanisms. Frontiers in Medicine. 2021;8:695792. DOI: 10.3389/fmed.2021.695792Salvatore T., Pafundi P.C., Galiero R. et al. The diabetic cardiomyopathy: the contributing pathophysiological mechanisms. Frontiers in Medicine. 2021;8:695792. DOI: 10.3389/fmed.2021.695792Jia G., DeMarco V.G., Sowers J.R. Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy. Nature Reviews Endocrinology. 2016;12(3):144–153. DOI: 10.1038/nrendo.2015.216Jia G., DeMarco V.G., Sowers J.R. Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy. Nature Reviews Endocrinology. 2016;12(3):144–153. DOI: 10.1038/nrendo.2015.216Gollmer J., Zirlik A., Bugger H. Mitochondrial mechanisms in diabetic cardiomyopathy. Diabetes & Metabolism Journal. 2020;44(1):33–53. DOI: 10.4093/dmj.2019.0185Gollmer J., Zirlik A., Bugger H. Mitochondrial mechanisms in diabetic cardiomyopathy. Diabetes & Metabolism Journal. 2020;44(1):33–53. DOI: 10.4093/dmj.2019.0185Simon D., Jocelyne M., Bertrand C., Xavier P. Chronic O-GlcNAcylation and diabetic cardiomyopathy: the bitterness of glucose. Frontiers in Endocrinology. 2018;9:642. DOI: 10.3389/fendo.2018.00642Simon D., Jocelyne M., Bertrand C., Xavier P. Chronic O-GlcNAcylation and diabetic cardiomyopathy: the bitterness of glucose. Frontiers in Endocrinology. 2018;9:642. DOI: 10.3389/fendo.2018.00642Laksono S., Hosea G.T., Nurusshofa Z. Diabetic cardiomyopathy: pathophysiology and novel therapies. Brown Hospital Medicine. 2022;1(3). DOI: 10.56305/001c.37850Laksono S., Hosea G.T., Nurusshofa Z. Diabetic cardiomyopathy: pathophysiology and novel therapies. Brown Hospital Medicine. 2022;1(3). DOI: 10.56305/001c.37850Murtaza G., Virk H.U.H., Khalid M. et al. Diabetic cardiomyopathy — A comprehensive updated review. Progress in Cardiovascular Diseases. 2019;62(4):315–326. DOI: 10.1016/j.pcad.2019.03.003Murtaza G., Virk H.U.H., Khalid M. et al. Diabetic cardiomyopathy — A comprehensive updated review. Progress in Cardiovascular Diseases. 2019;62(4):315–326. DOI: 10.1016/j.pcad.2019.03.003Yang L., Zhao D., Ren J., Yang J. Endoplasmic reticulum stress and protein quality control in diabetic cardiomyopathy. Biochimica et Biophysica Acta (BBA) — Molecular Basis of Disease. 2015;1852(2):209–218. DOI: 10.1016/j.bbadis.2014.05.006Yang L., Zhao D., Ren J., Yang J. Endoplasmic reticulum stress and protein quality control in diabetic cardiomyopathy. Biochimica et Biophysica Acta (BBA) — Molecular Basis of Disease. 2015;1852(2):209–218. DOI: 10.1016/j.bbadis.2014.05.006Nabi N.A., Ebihara A. Diabetes and renin-angiotensin-aldosterone system: pathophysiology and genetics. In book: Renin-Angiotensin Aldosterone System. Samy I. McFarlane Ed. London: IntechOpen, 2021:168. DOI: 10.5772/intechopen.97518Nabi N.A., Ebihara A. Diabetes and renin-angiotensin-aldosterone system: pathophysiology and genetics. In book: Renin-Angiotensin Aldosterone System. Samy I. McFarlane Ed. London: IntechOpen, 2021:168. DOI: 10.5772/intechopen.97518Jia G., Habibi J., DeMarco V.G. et al. Endothelial mineralocorticoid receptor deletion prevents diet-induced cardiac diastolic dysfunction in females. Hypertension. 2015;66:1159–1167. DOI: 10.1161/HYPERTENSIONAHA.115.06015Jia G., Habibi J., DeMarco V.G. et al. Endothelial mineralocorticoid receptor deletion prevents diet-induced cardiac diastolic dysfunction in females. Hypertension. 2015;66:1159–1167. DOI: 10.1161/HYPERTENSIONAHA.115.06015Singh R., Kaundal R., Zhao B. et al. Resistin induces cardiac fibroblast-myofi broblast differentiation through JAK/STAT3 and JNK/c-jun signaling. Pharmacological Research. 2021;167:105414. DOI: 10.1016/j.phrs.2020.105414Singh R., Kaundal R., Zhao B. et al. Resistin induces cardiac fibroblast-myofi broblast differentiation through JAK/STAT3 and JNK/c-jun signaling. Pharmacological Research. 2021;167:105414. DOI: 10.1016/j.phrs.2020.105414Cheng Y., Wang Y., Yin R. et al. Central role of cardiac fibroblasts in myocardial fi brosis of diabetic cardiomyopathy. Frontiers in Endocrinology. 2023;14:1162754. DOI: 10.3389/fendo.2023.1162754Cheng Y., Wang Y., Yin R. et al. Central role of cardiac fibroblasts in myocardial fi brosis of diabetic cardiomyopathy. Frontiers in Endocrinology. 2023;14:1162754. DOI: 10.3389/fendo.2023.1162754Pan K.-L., Hsu Y.-C., Chang S.-T. et al. The role of cardiac fibrosis in diabetic cardiomyopathy: from pathophysiology to clinical diagnostic tools. International Journal of Molecular Sciences (MDPI). 2023;24:8604. DOI: 10.3390/ijms24108604Pan K.-L., Hsu Y.-C., Chang S.-T. et al. The role of cardiac fibrosis in diabetic cardiomyopathy: from pathophysiology to clinical diagnostic tools. International Journal of Molecular Sciences (MDPI). 2023;24:8604. DOI: 10.3390/ijms24108604Ghosh N., Katare R. Molecular mechanism of diabetic cardiomyopathy and modulation of microRNA function by synthetic oligonucleotides. Cardiovascular Diabetology. 2018;17(1):43. DOI: 10.1186/s12933-018-0684-1Ghosh N., Katare R. Molecular mechanism of diabetic cardiomyopathy and modulation of microRNA function by synthetic oligonucleotides. Cardiovascular Diabetology. 2018;17(1):43. DOI: 10.1186/s12933-018-0684-1Brasacchio D., Okabe J., Tikellis С. et al. Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail. Diabetes. 2009;58(5):1229–1236. DOI: 10.2337/db08-1666Brasacchio D., Okabe J., Tikellis С. et al. Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail. Diabetes. 2009;58(5):1229–1236. DOI: 10.2337/db08-1666Gaikwad A.B., Sayyed S.G., Lichtnekert J. et al. Renal failure increases cardiac histone h3 acetylation, dimethylation, and phosphorylation and the induction of cardiomyopathy-related genes in type 2 diabetes. The American journal of pathology. 2010;176(3):1079–1083. DOI: 10.2353/ajpath.2010.090528Gaikwad A.B., Sayyed S.G., Lichtnekert J. et al. Renal failure increases cardiac histone h3 acetylation, dimethylation, and phosphorylation and the induction of cardiomyopathy-related genes in type 2 diabetes. The American journal of pathology. 2010;176(3):1079–1083. DOI: 10.2353/ajpath.2010.090528Asrih M., Steff ens S. Emerging role of epigenetics and miRNA in diabetic cardiomyopathy. Cardiovascular Pathology. 2013;22(2):117–125. DOI: 10.1016/j.carpath.2012.07.004Asrih M., Steff ens S. Emerging role of epigenetics and miRNA in diabetic cardiomyopathy. Cardiovascular Pathology. 2013;22(2):117–125. DOI: 10.1016/j.carpath.2012.07.004Gonzalo-Calvo D., Kenneweg F., Bang C. et al. Circulating long-non coding RNAs as biomarkers of left ventricular diastolic function and remodelling in patients with well-controlled type 2 diabetes. Scientific Reports. 2016;6:37354. DOI: 10.1038/srep37354Gonzalo-Calvo D., Kenneweg F., Bang C. et al. Circulating long-non coding RNAs as biomarkers of left ventricular diastolic function and remodelling in patients with well-controlled type 2 diabetes. Scientific Reports. 2016;6:37354. DOI: 10.1038/srep37354Pant T., Dhanasekaran A., Fang J. et al. Current status and strategies of long noncoding RNA research for diabetic cardiomyopathy. BMC Cardiovascular Disorders. 2018;18:197. DOI: 10.1186/s12872-018-0939-5.Pant T., Dhanasekaran A., Fang J. et al. Current status and strategies of long noncoding RNA research for diabetic cardiomyopathy. BMC Cardiovascular Disorders. 2018;18:197. DOI: 10.1186/s12872-018-0939-5.Pordzik J., Jakubik D., Jarosz-Popek J. et al. Significance of circulating microRNAs in diabetes mellitus type 2 and platelet reactivity: bioinformatic analysis and review. Cardiovascular Diabetology. 2019;18(1):113. DOI: 10.1186/s12933-019-0918-xPordzik J., Jakubik D., Jarosz-Popek J. et al. Significance of circulating microRNAs in diabetes mellitus type 2 and platelet reactivity: bioinformatic analysis and review. Cardiovascular Diabetology. 2019;18(1):113. DOI: 10.1186/s12933-019-0918-xJakubik D., Fitas A., Eyileten C. et al. MicroRNAs and long non-coding RNAs in the pathophysiological processes of diabetic cardiomyopathy: emerging biomarkers and potential therapeutics. Cardiovascular Diabetology. 2021;20:55. DOI: 10.1186/s12933-021-01245-2Jakubik D., Fitas A., Eyileten C. et al. MicroRNAs and long non-coding RNAs in the pathophysiological processes of diabetic cardiomyopathy: emerging biomarkers and potential therapeutics. Cardiovascular Diabetology. 2021;20:55. DOI: 10.1186/s12933-021-01245-2Zhou Y., Suo W., Zhang X. et al. Targeting epigenetics in diabetic cardiomyopathy: Therapeutic potential of flavonoids. Biomedicine & Pharmacotherapy. 2023;157: 114025. DOI: 10.1016/j.biopha.2022.114025Zhou Y., Suo W., Zhang X. et al. Targeting epigenetics in diabetic cardiomyopathy: Therapeutic potential of flavonoids. Biomedicine & Pharmacotherapy. 2023;157: 114025. DOI: 10.1016/j.biopha.2022.114025Himangi V., Ravinandan A.P., Hunsur V.N. et al. An insight into the pathogenesis of diabetic cardiomyopathy along with the novel potential therapeutic approaches. Current Diabetes Reviews. 2023;20(1):e020523216416. DOI: 10.2174/1573399819666230502110511Himangi V., Ravinandan A.P., Hunsur V.N. et al. An insight into the pathogenesis of diabetic cardiomyopathy along with the novel potential therapeutic approaches. Current Diabetes Reviews. 2023;20(1):e020523216416. DOI: 10.2174/1573399819666230502110511Jia G., Whaley-Connell A., Sowers J.R. Diabetic cardiomyopathy: a hyperglycaemia- and insulin-resistance-induced heart disease. Diabetologia. 2018;61:21–28. DOI: 10.1007/s00125-017-4390-4Jia G., Whaley-Connell A., Sowers J.R. Diabetic cardiomyopathy: a hyperglycaemia- and insulin-resistance-induced heart disease. Diabetologia. 2018;61:21–28. DOI: 10.1007/s00125-017-4390-4Pathophysiology of heart disease: a collaborative project of medical students and faculty, 5<sup>th</sup> ed. L.S. Lilly eds. Philadelphia: Lippincott Williams and Wilkins, 2010:461.Pathophysiology of heart disease: a collaborative project of medical students and faculty, 5<sup>th</sup> ed. L.S. Lilly eds. Philadelphia: Lippincott Williams and Wilkins, 2010:461.Войнов В.А. Патофизиология сердца и сосудов. Учебное пособие. Москва: Издательский дом БИНОМ, 2017:208.Voynov V.A. Pathophysiology of the heart and blood vessels. Tutorial. Moscow: Izdatelskiy dom BINOM, 2017:208. (In Russian).Лекции по сердечно-сосудистой хирургии, 3-е издание, переработанное и дополненное. Под ред. Л.А. Бокерия. Москва: НЦССХ им. А.Н. Бакулева РАМН, 2013:764. [Электронный ресурс]. URL: http://www.scienceforum.ru/2015/898/13403Cardiovascular Surgery Lectures, 3<sup>rd</sup> ed., revised and expanded. Bokeriia L.A. eds. Moscow: NCSSH im. A.N. Bakuleva RAMN, 2013:764. (In Russian).Kouchoukos N.T., Blackstone E.H., Hanley F.L., Kirklin J.K. Kirklin/Barratt-boyes cardiac surgery: morphology, diagnostic criteia, natural history, techniques, results, and indications, 4<sup>th</sup> ed, 2-Volume set. Philadelphia: Elsevier Saunders, 2013;1–2:2256.Kouchoukos N.T., Blackstone E.H., Hanley F.L., Kirklin J.K. Kirklin/Barratt-boyes cardiac surgery: morphology, diagnostic criteia, natural history, techniques, results, and indications, 4<sup>th</sup> ed, 2-Volume set. Philadelphia: Elsevier Saunders, 2013;1–2:2256.Kurniawaty J., Setianto B.Y., Supomo S. Outcome Comparison Between Insulin-Dependent and Non-Insulin-Dependent Patients after Open Adult Cardiac Surgery. Solo Journal of Anesthesi, Pain and Critical Care (SOJA). 2023;3(1):51–62. DOI: 10.20961/soja.v3i1.66306Kurniawaty J., Setianto B.Y., Supomo S. Outcome Comparison Between Insulin-Dependent and Non-Insulin-Dependent Patients after Open Adult Cardiac Surgery. Solo Journal of Anesthesi, Pain and Critical Care (SOJA). 2023;3(1):51–62. DOI: 10.20961/soja.v3i1.66306Cohen O., Dankner R., Chetrit A., et al. Multidisciplinary intervention for control of diabetes in patients undergoing coronary artery bypass graft (CABG). Cardiovascular Surgery. 2016;11:195–200. DOI: 10.1177/096721090301100304Cohen O., Dankner R., Chetrit A., et al. Multidisciplinary intervention for control of diabetes in patients undergoing coronary artery bypass graft (CABG). Cardiovascular Surgery. 2016;11:195–200. DOI: 10.1177/096721090301100304Arnaout A., Goge S. Effect of Preadmission Diabetes Intervention (PREHAB) on Postoperative Patient Outcomes in Cardiac Surgery. Diabetes. 2018;67(1):727–P. DOI: 10.2337/db18-727-PArnaout A., Goge S. Effect of Preadmission Diabetes Intervention (PREHAB) on Postoperative Patient Outcomes in Cardiac Surgery. Diabetes. 2018;67(1):727–P. DOI: 10.2337/db18-727-PLuthra S., Salhiyyah K., Dritsakis G., et al. Diabetes management during cardiac surgery in the UK: A survey. Diabetic Medicine. 2021;38:e14388. DOI: 10.1111/dme.14388Luthra S., Salhiyyah K., Dritsakis G., et al. Diabetes management during cardiac surgery in the UK: A survey. Diabetic Medicine. 2021;38:e14388. DOI: 10.1111/dme.14388Holt R.I.G., Dritsakis G., Barnard-Kelly K.D. et al. The Optimising Cardiac Surgery ouTcOmes in People with diabeteS (OCTOPuS) randomised controlled trial to evaluate an outpatient pre-cardiac surgery diabetes management intervention: a study protocol. BMJ Open. 2021;11(6):e050919. DOI: 10.1136/bmjopen-2021-050919Holt R.I.G., Dritsakis G., Barnard-Kelly K.D. et al. The Optimising Cardiac Surgery ouTcOmes in People with diabeteS (OCTOPuS) randomised controlled trial to evaluate an outpatient pre-cardiac surgery diabetes management intervention: a study protocol. BMJ Open. 2021;11(6):e050919. DOI: 10.1136/bmjopen-2021-050919Sadler T.W. Langman’s Medical Embryology, 12<sup>th</sup> ed. Philadelphia: Lippincott Williams & Wilkins, 2011:384.Sadler T.W. Langman’s Medical Embryology, 12<sup>th</sup> ed. Philadelphia: Lippincott Williams & Wilkins, 2011:384.Шевченко Ю.Л. Принцип поочередного сокращения кардиомиоцитов и их ассоциаций. Новая концепция физиологии работы сердца. Вестник НМХЦ им. Н.И. Пирогова. 2022;17(1):4–8. DOI: 10.25881/20728255_2022_17_1_4Shevchenko Yu.L. The principle of alternating contraction of cardiomyocytes and their associations. The new concept of the heart physiology. Vestnik NMHC im. N.I. Pirogova. 2022;17(1):4–8. (In Russian). DOI: 10.25881/20728255_2022_17_1_4Абдул-Оглы Л.В., Инджикулян А.А. Особенности васкуляризации и пролиферации региональных участков стенки сердца человека в онтогенезе. Вестник проблем биологии и медицины. 2005;2:104–108.Abdul-Ogly L.V., Indzhikulyan A.A. Features of vascularization and proliferation of regional sections of the human heart wall in ontogeny. Vestnik problem biologii i meditsiny. 2005;2:104–108. (In Russian)Шиян Д.Н., Поликов Г.О., Завгородний А.С. Кровоснабжение клапанов сердца человека. VII Международная студенческая электронная научная конференция, Харьков, 2015. URL: http://www.scienceforum.ru/2015/898/13403Shiyan D.N., Polikov G.O., Zavgorodniy A.S. Blood supply to human heart valves. VII International Student Electronic Scientifi c Conference, Kharkiv, 2015. (In Russian). [Electronic resource]. URL: http://www.scienceforum.ru/2015/898/13403Федонюк Л.Я., Семенюк Т.А., Малик Ю.Ю. и др. Микроскопическое строение и кровоснабжение клапанов сердца в норме и при приобретенных пороках сердца различного генеза. Актуальные вопросы морфологии. Труды Международной научной конференции, посвященной 100-летию со дня рождения проф. Б.З. Перлина, Кишинев, 2012:363–367.Fedoniuk L.Ya., Semeniuk T.A., Malik T.A. et al. Blood supply of normal heart valves and diseased heart valves of an infl ammatory and non-inflammatory genesis. Actual issues of morphology. Materials of the International Scientific Conference dedicated to the birth centenary of Professor B.Z. Perlin, Chisinau, 2012:363–367. (In Russian).Митрофанова Л.Б., Ковальский Г.Б. Морфологическая характеристика и дифференциальная диагностика заболеваний клапанов сердца. Архив патологии. 2007;69(1):24–31.Mitrofanova L.B., Kovalsky G.B. Morphological characteristics and differential diagnosis of heart valve diseases. Arkhiv patologii. 2007;69(1):24–31. (In Russian)Синельников Р.Д., Синельников Я.Р. Атлас анатомии человека : учебное пособие, 2-е издание, стереотипное, в 4 томах. Том 3. Москва: Медицина, 1996:232.Sinelnikov R.D., Sinelnikov Ya.R. Atlas of human anatomy: tutorial, 2nd ed., stereotypical, 4-Volume set. Volume 3. Moscow: Medicine, 1996:232. (In Russian).Strelnikova E.A., Kalinin R.E., Suchkov I.A. et al. Molecular and cellular aspects of the endothelial–mesenchymal transition in cardiovascular diseases. Molecular Biology. 2023;57:563–571. DOI: 10.1134/S0026893323030111Strelnikova E.A., Kalinin R.E., Suchkov I.A. et al. Molecular and cellular aspects of the endothelial–mesenchymal transition in cardiovascular diseases. Molecular Biology. 2023;57:563–571. DOI: 10.1134/S0026893323030111Sielicka A., Sarin E.L., Shi W. et al. Pathological remodeling of mitral valve leafl ets from unphysiological leafl et mechanics after undersized mitral annuloplasty to repair ischemic mitral regurgitation. Journal of the American Heart Association. 2018;7(21):e009777. DOI: 10.1161/JAHA.118.009777Sielicka A., Sarin E.L., Shi W. et al. Pathological remodeling of mitral valve leafl ets from unphysiological leafl et mechanics after undersized mitral annuloplasty to repair ischemic mitral regurgitation. Journal of the American Heart Association. 2018;7(21):e009777. DOI: 10.1161/JAHA.118.009777Selig J.I., Ouwens D.M., Raschke S. et al. Impact of hyperinsulinemia and hyperglycemia on valvular interstitial cells — A link between aortic heart valve degeneration and type 2 diabetes. Biochimica et Biophysica Acta (BBA) — Molecular Basis of Disease. 2019;1865(9):2526–2537. DOI: 10.1016/j.bbadis.2019.05.019Selig J.I., Ouwens D.M., Raschke S. et al. Impact of hyperinsulinemia and hyperglycemia on valvular interstitial cells — A link between aortic heart valve degeneration and type 2 diabetes. Biochimica et Biophysica Acta (BBA) — Molecular Basis of Disease. 2019;1865(9):2526–2537. DOI: 10.1016/j.bbadis.2019.05.019Yoshimatsu Y., Watabe T. Roles of TGF-β signals in endothelial-mesenchymal transition during cardiac fi brosis. International Journal of Inflammation. 2011;2011:724080. DOI: 10.4061/2011/724080Yoshimatsu Y., Watabe T. Roles of TGF-β signals in endothelial-mesenchymal transition during cardiac fi brosis. International Journal of Inflammation. 2011;2011:724080. DOI: 10.4061/2011/724080Lin H., Guan L., Meng L. et al. SGLT1 knockdown attenuates cardiac fibroblast activation in diabetic cardiac fi brosis. Frontiers in Pharmacology. 2021;12:700366. DOI: 10.3389/fphar.2021.700366Lin H., Guan L., Meng L. et al. SGLT1 knockdown attenuates cardiac fibroblast activation in diabetic cardiac fi brosis. Frontiers in Pharmacology. 2021;12:700366. DOI: 10.3389/fphar.2021.700366Larsson S.C., Wallin A., Håkansson N. et al. Type 1 and type 2 diabetes mellitus and incidence of seven cardiovascular diseases. International Journal of Cardiology. 2018;262:66–70. DOI: 10.1016/j.ijcard.2018.03.099Larsson S.C., Wallin A., Håkansson N. et al. Type 1 and type 2 diabetes mellitus and incidence of seven cardiovascular diseases. International Journal of Cardiology. 2018;262:66–70. DOI: 10.1016/j.ijcard.2018.03.099Kovacic J.C., Dimmeler S, Harvey R.P. et al. Endothelial to mesenchymal transition in cardiovascular disease: JACC state-of-the-art review. Journal of the American College of Cardiology (JACC). 2019;73(2):190–209. DOI: 10.1016/j.jacc.2018.09.089Kovacic J.C., Dimmeler S, Harvey R.P. et al. Endothelial to mesenchymal transition in cardiovascular disease: JACC state-of-the-art review. Journal of the American College of Cardiology (JACC). 2019;73(2):190–209. DOI: 10.1016/j.jacc.2018.09.089

The authors declare that there are no conflicts of interest present.