clinmedКлиническая медицинаClinical Medicine (Russian Journal)0023-21492412-1339ООО «Медицинское информационное агентство»10.30629/0023-2149-2023-101-9-10-449-453clinmed-628Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESCиндром Бехчета и беременностьBehcet's syndrome and pregnancyhttps://orcid.org/0000-0003-2228-3884ЦхайВ. Б.TskhaiV. B.

Цхай Виталий Борисович — д-р мед. наук, профессор, заведующий кафедрой перинатологии, акушерства и гинекологии

660022, Красноярск

Tskhai Vitaly B.

660022, Krasnoyarsk

https://orcid.org/0000-0001-8652-1410ШестерняП. А.ShesternyaP. A.

Шестерня Павел Анатольевич — д-р мед. наук, профессор, заведующий кафедрой пропедевтики внутренних болезней и терапии с курсом ПО, проректор по научной работе

660022, Красноярск

Shesternya Pavel A.

660022, Krasnoyarsk

sci-prorector@krasgmu.ruФГБОУ ВО «Красноярский государственный медицинский университет имени профессора В.Ф. Войно-Ясенецкого» Минздрава РоссииРоссияProf. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University of the Ministry of Healthcare of the Russian FederationRussian Federation2023121120231019-10449453Copyright © Цхай В.Б., Шестерня П.А., 20232023Цхай В.Б., Шестерня П.А.Tskhai V.B., Shesternya P.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.clinmedjournal.com/jour/article/view/628

Планирование и ведение беременности на фоне имеющегося ревматического заболевания является серьезной проблемой, широко обсуждаемой в медицинском сообществе. Синдром Бехчета (болезнь Бехчета) в данном контексте один из наименее изученных. Данные о взаимном влиянии васкулита и беременности на течение и исходы противоречивы. Очевидна необходимость междисциплинарного сопровождения беременности акушером-гинекологом и ревматологом для минимизации риска потерь и осложнений в этой сложной клинической ситуации. В настоящем обзоре приведены данные, опубликованные в течение последних двух десятилетий использования в ревматологии генно-инженерных биологических препаратов.

Planning and managing pregnancy in the context of an existing rheumatic disease is a serious problem widely discussed in the medical community. Behcet’s syndrome (Behcet’s disease) is one of the least studied diseases in this context. Data on the mutual influence of vasculitis and pregnancy on the course and outcomes are contradictory. There is an obvious need for interdisciplinary support of pregnancy by an obstetrician-gynecologist and a rheumatologist to minimize the risk of losses and complications in this complex clinical situation. This review presents data published over the past two decades on the use of genetically engineered biological drugs in rheumatology.

синдром Бехчетаболезнь БехчетабеременностьрепродукцияBehcet’s syndromeBehcet’s diseasepregnancyreproductionReferencesTirilomis T. Some more historical notes on Adamantiades-Behçet’s disease. Chest. 2001;120(6):2116. DOI: 10.1378/chest.120.6.2116Tirilomis T. Some more historical notes on Adamantiades-Behçet’s disease. Chest. 2001;120(6):2116. DOI: 10.1378/chest.120.6.2116Bettiol A., Prisco D., Emmi G. Behçet: syndrome. Rheumatology (Oxford). 2020;59(3):iii101–iii107. DOI: 10.1093/rheumatology/kez626Bettiol A., Prisco D., Emmi G. Behçet: syndrome. Rheumatology (Oxford). 2020;59(3):iii101–iii107. DOI: 10.1093/rheumatology/kez626Chen J., Yao X. A contemporary review of Behcet. Clin. Rev. Allergy Immunol. 2021;61(3):363–376. DOI: 10.1007/s12016-021-08864-3Chen J., Yao X. A contemporary review of Behcet. Clin. Rev. Allergy Immunol. 2021;61(3):363–376. DOI: 10.1007/s12016-021-08864-3Xenitidis T., Henes J.C. Behçet’s syndrome. Laryngorhinootologie. 2020;99(6):377–390. DOI: 10.1055/a-1076-9742Xenitidis T., Henes J.C. Behçet’s syndrome. Laryngorhinootologie. 2020;99(6):377–390. DOI: 10.1055/a-1076-9742Nair J.R., Moots R.J. Behcet’s disease. Clin. Med. (Lond). 2017;17(1):71–77. DOI: 10.7861/clinmedicine.17-1-71Nair J.R., Moots R.J. Behcet’s disease. Clin. Med. (Lond). 2017;17(1):71–77. DOI: 10.7861/clinmedicine.17-1-71Greco A., De Virgilio A., Ralli M., Ciofalo A., Mancini P., Attana sio G., de Vincentiis M., Lambiase A. Behçet’s disease: New insights into pathophysiology, clinical features and treatment options. Autoimmun. Rev. 2018;17(6):567–575. DOI: 10.1016/j.autrev.2017.12.006Greco A., De Virgilio A., Ralli M., Ciofalo A., Mancini P., Attana sio G., de Vincentiis M., Lambiase A. Behçet’s disease: New insights into pathophysiology, clinical features and treatment options. Autoimmun. Rev. 2018;17(6):567–575. DOI: 10.1016/j.autrev.2017.12.006Hou C.C., Luo D, Bao H.F., Ye J.F., Ma H.F., Shen Y., Zou J., Guan J.L. Clinical heterogeneity of ocular Behçet’s syndrome versus intestinal Behçet’s syndrome: a cross-sectional study from Shanghai Behçet’s syndrome database. Arthritis Res. Ther. 2022;24(1):98. DOI: 10.1186/s13075-022-02782-1Hou C.C., Luo D, Bao H.F., Ye J.F., Ma H.F., Shen Y., Zou J., Guan J.L. Clinical heterogeneity of ocular Behçet’s syndrome versus intestinal Behçet’s syndrome: a cross-sectional study from Shanghai Behçet’s syndrome database. Arthritis Res. Ther. 2022;24(1):98. DOI: 10.1186/s13075-022-02782-1Azizlerli G., Köse A.A., Sarica R., Gül A., Tutkun I.T., Kulaç M., Tunç R., Urgancioğlu M., Dişçi R. Prevalence of Behçet’s disease in Istanbul, Turkey. Int. J. Dermatol. 2003;42(10):803–6.Azizlerli G., Köse A.A., Sarica R., Gül A., Tutkun I.T., Kulaç M., Tunç R., Urgancioğlu M., Dişçi R. Prevalence of Behçet’s disease in Istanbul, Turkey. Int. J. Dermatol. 2003;42(10):803–6.Störk S., Kneitz C., Bröcker E.B., Hoyer C., Ertl G., Angermann C.E. Adamantiades-Behçet’s disease. Clinical review. Med. Klin. (Munich). 2008;103(3):143–52. DOI: 10.1007/s00063-008-1021-3Störk S., Kneitz C., Bröcker E.B., Hoyer C., Ertl G., Angermann C.E. Adamantiades-Behçet’s disease. Clinical review. Med. Klin. (Munich). 2008;103(3):143–52. DOI: 10.1007/s00063-008-1021-3Yazici H., Seyahi E., Hatemi G., Yazici Y. Behcet syndrome: a contemporary view. Nat. Rev. Rheumatol. 2018;14(2):107–19.Yazici H., Seyahi E., Hatemi G., Yazici Y. Behcet syndrome: a contemporary view. Nat. Rev. Rheumatol. 2018;14(2):107–19.Алекберова З.С., Лисицына Т.А., Голоева Р.Г., Давыдова Г.А. Болезнь Бехчета: клинико-гендерные ассоциации. Современная ревматология. 2019;13(2):84–89.Alekberova Z.S., Lisitsyna T.A., Goloeva R.G., Davydova G.A. Behcet’s disease: clinical and gender associations. Sovremennaya revmatologiya. 2019;13(2):84–89. (In Russian).Uygunoğlu U., Siva A. Behçet’s Syndrome and Nervous System Involvement. Curr. Neurol. Neurosci. Rep. 2018;18(7):35. DOI: 10.1007/s11910-018-0843-5Uygunoğlu U., Siva A. Behçet’s Syndrome and Nervous System Involvement. Curr. Neurol. Neurosci. Rep. 2018;18(7):35. DOI: 10.1007/s11910-018-0843-5Bettiol A., Hatemi G., Vannozzi L., Barilaro A., Prisco D., Emmi G. Treating the different phenotypes of Behçet’s syndrome. Front. Immunol. 2019;10:2830. DOI: 10.3389/fimmu.2019.02830Bettiol A., Hatemi G., Vannozzi L., Barilaro A., Prisco D., Emmi G. Treating the different phenotypes of Behçet’s syndrome. Front. Immunol. 2019;10:2830. DOI: 10.3389/fimmu.2019.02830Hatemi G., Christensen R., Bang D. et al. 2018 update of the EULAR recommendations for the management of Behçet’s syndrome. Ann. Rheum. Dis. 2018;77(6):808–818. DOI: 10.1136/annrheumdis-2018-213225Hatemi G., Christensen R., Bang D. et al. 2018 update of the EULAR recommendations for the management of Behçet’s syndrome. Ann. Rheum. Dis. 2018;77(6):808–818. DOI: 10.1136/annrheumdis-2018-213225Hatemi G., Seyahi E., Fresko I., Talarico R., Hamuryudan V. Behçet’s syndrome: a critical digest of the 2014–2015 literature. Clin. Exp. Rheumatol. 2015;33(6 Suppl 94):S3–14.Hatemi G., Seyahi E., Fresko I., Talarico R., Hamuryudan V. Behçet’s syndrome: a critical digest of the 2014–2015 literature. Clin. Exp. Rheumatol. 2015;33(6 Suppl 94):S3–14.Hatemi G., Seyahi E., Fresko I., Talarico R., Uçar D., Hamuryudan V. Behçet’s syndrome: one year in review 2022. Clin. Exp. Rheumatol. 2022;40(8):1461–1471. DOI: 10.55563/clinexprheumatol/h4dkrsHatemi G., Seyahi E., Fresko I., Talarico R., Uçar D., Hamuryudan V. Behçet’s syndrome: one year in review 2022. Clin. Exp. Rheumatol. 2022;40(8):1461–1471. DOI: 10.55563/clinexprheumatol/h4dkrsMat C., Yurdakul S., Sevim A., Özyazgan Y., Tüzün Y. Behçet’s syndrome: facts and controversies. Clin. Dermatol. 2013;31(4):352– 361. DOI: 10.1016/j.clindermatol.2013.01.002Mat C., Yurdakul S., Sevim A., Özyazgan Y., Tüzün Y. Behçet’s syndrome: facts and controversies. Clin. Dermatol. 2013;31(4):352– 361. DOI: 10.1016/j.clindermatol.2013.01.002Моисеев С.В., Буланов Н.М., Каровайкина Е.А., Носова Н.Р., Макаров П.И. Современные представления о болезни Бехчета. Клиническая фармакология и терапия. 2018;27(3):58–66.Moiseev S.V., Bulanov N.M., Karavaikina E.A., Nosova N.R., Makarov P.I. Modern ideas about Behcet’s disease. Clinical pharmacology and therapy. 2018;27(3):58–66. (In Russian).Zou J., Luo J.F., Shen Y., Cai J.F., Guan J.L. Cluster analysis of phenotypes of patients with Behçet’s syndrome: a large cohort study from a referral center in China. Arthritis Res. Ther. 2021;23(1):45. DOI: 10.1186/s13075-021-02429-7Zou J., Luo J.F., Shen Y., Cai J.F., Guan J.L. Cluster analysis of phenotypes of patients with Behçet’s syndrome: a large cohort study from a referral center in China. Arthritis Res. Ther. 2021;23(1):45. DOI: 10.1186/s13075-021-02429-7Seyahi E. Phenotypes in Behçet’s syndrome. Intern. Emerg. Med. 2019;14:677–689. DOI: 10.1007/s11739-019-02046-ySeyahi E. Phenotypes in Behçet’s syndrome. Intern. Emerg. Med. 2019;14:677–689. DOI: 10.1007/s11739-019-02046-yİlgen U. Clusters in Behçet’s. Arthritis Res. Ther. 2022;24(1):242. DOI: 10.1186/s13075-022-02937-0İlgen U. Clusters in Behçet’s. Arthritis Res. Ther. 2022;24(1):242. DOI: 10.1186/s13075-022-02937-0Kidd D.P. Neurological complications of Behçet. J. Neurol. 2017;264(10):2178–2183. DOI: 10.1007/s00415-017-8436-9Kidd D.P. Neurological complications of Behçet. J. Neurol. 2017;264(10):2178–2183. DOI: 10.1007/s00415-017-8436-9Zeidan M.J., Saadoun D., Garrido M., Klatzmann D., Six A., Cacoub P. Behçet’s disease physiopathology: a contemporary review. Auto Immun. Highlights. 2016;7(1):4. DOI: 10.1007/s13317-016-0074-1Zeidan M.J., Saadoun D., Garrido M., Klatzmann D., Six A., Cacoub P. Behçet’s disease physiopathology: a contemporary review. Auto Immun. Highlights. 2016;7(1):4. DOI: 10.1007/s13317-016-0074-1Alakkas Z., Kazi W., Mattar M., Salem E.A.W., Seleem N.F. Pulmonary artery thrombosis as the fi rst presentation of Behçet’s syndrome: a case report and review of the literature. J. Med. Case Rep. 2021;15(1):322. DOI: 10.1186/s13256-021-02931-1Alakkas Z., Kazi W., Mattar M., Salem E.A.W., Seleem N.F. Pulmonary artery thrombosis as the fi rst presentation of Behçet’s syndrome: a case report and review of the literature. J. Med. Case Rep. 2021;15(1):322. DOI: 10.1186/s13256-021-02931-1Ozguler Y., Hatemi G. Management of Behçet’s syndrome. Curr. Opin. Rheumatol. 2016;28(1):45–50. DOI: 10.1097/BOR.0000000000000231Ozguler Y., Hatemi G. Management of Behçet’s syndrome. Curr. Opin. Rheumatol. 2016;28(1):45–50. DOI: 10.1097/BOR.0000000000000231Xenitidis T., Henes J.C. Behçet’s Syndrome. Laryngorhinootologie. 2020;99(6):377–390. DOI: 10.1055/a-1076-9742Xenitidis T., Henes J.C. Behçet’s Syndrome. Laryngorhinootologie. 2020;99(6):377–390. DOI: 10.1055/a-1076-9742Kötter I. Behçet’s syndrome: Current diagnostics and treatment. Z. Rheumatol. 2020;79(9):873–882. DOI: 10.1007/s00393-020-00899-9Kötter I. Behçet’s syndrome: Current diagnostics and treatment. Z. Rheumatol. 2020;79(9):873–882. DOI: 10.1007/s00393-020-00899-9Ince-Askan H., Dolhain R.J., Ince-Askan H., Dolhain R.J. Pregnancy and rheumatoid arthritis. Best Pract. Res. Clin. Rheumatol. 2015;29(4–5):580–96. DOI: 10.1016/j.berh.2015.07.001Ince-Askan H., Dolhain R.J., Ince-Askan H., Dolhain R.J. Pregnancy and rheumatoid arthritis. Best Pract. Res. Clin. Rheumatol. 2015;29(4–5):580–96. DOI: 10.1016/j.berh.2015.07.001Rodrigues M., Andreoli L., Tincani A. Management of Gender-Related Problems in Women with Autoimmune Rheumatic Diseases. Isr. Med. Assoc. J. 2016;18(3–4):183–7.Rodrigues M., Andreoli L., Tincani A. Management of Gender-Related Problems in Women with Autoimmune Rheumatic Diseases. Isr. Med. Assoc. J. 2016;18(3–4):183–7.Алекберова З.С., Бижанова Д.А. Болезнь Бехчета: репродуктивная функция и беременность. Современная ревматология. 2018;12(2):103–106.Alekberova Z.S., Bizhanova D.A. Behcet’s disease: reproductive function and pregnancy. Sovremennaya revmatologiya. 2018;12(2):103–106. (In Russian).Alekberova Z.,. Goloeva R., Cherkasova M., Lila A., Nasonova VA. Ovarian reserve in Behchet’s Disease. Аnn Rheum Dis: Scientifi c Abstracts of European Congress of Rheumatology. 2022;81(1):1748-49.Alekberova Z.,. Goloeva R., Cherkasova M., Lila A., Nasonova VA. Ovarian reserve in Behchet’s Disease. Аnn Rheum Dis: Scientifi c Abstracts of European Congress of Rheumatology. 2022;81(1):1748-49.Jadaon J., Shushan A., Ezra Y., Sela H.Y., Ozcan C., Rojansky N. Behçet’s disease and pregnancy. Acta Obstet Gynecol Scand. 2005;84(10):939–44. DOI: 10.1111/j.0001-6349.2005.00761.xJadaon J., Shushan A., Ezra Y., Sela H.Y., Ozcan C., Rojansky N. Behçet’s disease and pregnancy. Acta Obstet Gynecol Scand. 2005;84(10):939–44. DOI: 10.1111/j.0001-6349.2005.00761.xXu C., Bao S. Behcet’s disease and pregnancy-a case report and literature review. Am. J. Reprod. Immunol. 2017;77(1). DOI: 10.1111/aji.12530Xu C., Bao S. Behcet’s disease and pregnancy-a case report and literature review. Am. J. Reprod. Immunol. 2017;77(1). DOI: 10.1111/aji.12530Lee S., Czuzoj-Shulman N., Abenhaim H.A. Behcet’s disease and pregnancy: obstetrical and neonatal outcomes in a population-based cohort of 12 million births. J. Perinat. Med. 2019;47(4):381–387. DOI: 10.1515/jpm-2018-0161Lee S., Czuzoj-Shulman N., Abenhaim H.A. Behcet’s disease and pregnancy: obstetrical and neonatal outcomes in a population-based cohort of 12 million births. J. Perinat. Med. 2019;47(4):381–387. DOI: 10.1515/jpm-2018-0161Arbrile M., Radin M., Rossi D., Menegatti E., Roccatello D., Sciascia S. Pregnancy outcomes in Behçet’s disease: Results from a monocentric cohort. J. Reprod. Immunol. 2022;153:103682. DOI: 10.1016/j.jri.2022.103682Arbrile M., Radin M., Rossi D., Menegatti E., Roccatello D., Sciascia S. Pregnancy outcomes in Behçet’s disease: Results from a monocentric cohort. J. Reprod. Immunol. 2022;153:103682. DOI: 10.1016/j.jri.2022.103682Ben-Chetrit E. Behçet’s syndrome and pregnancy: course of the disease and pregnancy outcome. Clin. Exp. Rheumatol. 2014;32 (4 Suppl 84):S93–8.Ben-Chetrit E. Behçet’s syndrome and pregnancy: course of the disease and pregnancy outcome. Clin. Exp. Rheumatol. 2014;32 (4 Suppl 84):S93–8.Mainini G., Di Donna M.C., Esposito E., Ercolano S., Correa R., Stradella L., Della Gala A., De Franciscis P. Pregnancy management in Behçet’s disease treated with uninterrupted infl iximab. Report of a case with fetal growth restriction and mini-review of the literature. Clin. Exp. Obstet. Gynecol. 2014;41(2):205–7.Mainini G., Di Donna M.C., Esposito E., Ercolano S., Correa R., Stradella L., Della Gala A., De Franciscis P. Pregnancy management in Behçet’s disease treated with uninterrupted infl iximab. Report of a case with fetal growth restriction and mini-review of the literature. Clin. Exp. Obstet. Gynecol. 2014;41(2):205–7.Bang D., Chun Y.S., Haam I.B., Lee E.S., Lee S.Yonsei The infl uence of pregnancy on Behçet’s. Med. J. 1997;38(6):437–43. DOI: 10.3349/ymj.1997.38.6.437Bang D., Chun Y.S., Haam I.B., Lee E.S., Lee S.Yonsei The infl uence of pregnancy on Behçet’s. Med. J. 1997;38(6):437–43. DOI: 10.3349/ymj.1997.38.6.437Uzun S., Alpsoy E., Durdu M., Akman A. The clinical course of Behçet’s disease in pregnancy: a retrospective analysis and review of the literature. J. Dermatol. 2003;30(7):499–502. DOI: 10.1111/j.1346-8138.2003.tb00423.xUzun S., Alpsoy E., Durdu M., Akman A. The clinical course of Behçet’s disease in pregnancy: a retrospective analysis and review of the literature. J. Dermatol. 2003;30(7):499–502. DOI: 10.1111/j.1346-8138.2003.tb00423.xNoel N., Wechsler B., Nizard J., Costedoat-Chalumeau N., Boutin du L.T., Dommergues M., Vauthier-Brouzes D., Cacoub P., Saadoun D. Behçet’s disease and pregnancy. Arthritis Rheum. 2013;65(9):2450–6. DOI: 10.1002/art.38052Noel N., Wechsler B., Nizard J., Costedoat-Chalumeau N., Boutin du L.T., Dommergues M., Vauthier-Brouzes D., Cacoub P., Saadoun D. Behçet’s disease and pregnancy. Arthritis Rheum. 2013;65(9):2450–6. DOI: 10.1002/art.38052Iskender C., Yasar O., Kaymak O., Yaman ST., Uygur D., Danisman N. Behçet’s disease and pregnancy: a retrospective analysis of course of disease and pregnancy outcome. J Obstet Gynaecol Res. 2014;40(6):1598–602. DOI: 10.1111/jog.12386Iskender C., Yasar O., Kaymak O., Yaman ST., Uygur D., Danisman N. Behçet’s disease and pregnancy: a retrospective analysis of course of disease and pregnancy outcome. J Obstet Gynaecol Res. 2014;40(6):1598–602. DOI: 10.1111/jog.12386Merlino L., Del Prete F., Lobozzo B., Priori R., Piccioni M.G. Behcet’s disease and pregnancy: a systematic review. Minerva Ginecol. 2020;72(5):332–338. DOI: 10.23736/S0026-4784.20.04564-5Merlino L., Del Prete F., Lobozzo B., Priori R., Piccioni M.G. Behcet’s disease and pregnancy: a systematic review. Minerva Ginecol. 2020;72(5):332–338. DOI: 10.23736/S0026-4784.20.04564-5Buntrock A., McNamara M., Tantoush H., Von Wald T. Worsening of Behcet syndrome symptoms during pregnancy. S. D. Med. 2021;74(3):112–114.Buntrock A., McNamara M., Tantoush H., Von Wald T. Worsening of Behcet syndrome symptoms during pregnancy. S. D. Med. 2021;74(3):112–114.La Regina M., Gasparyan A.Y., Orlandini F., Prisco D. Behçet’s Disease as a Model of Venous Thrombosis. Open Cardiovasc. Med. J. 2010 23;4:71–7. DOI: 10.2174/1874192401004020071La Regina M., Gasparyan A.Y., Orlandini F., Prisco D. Behçet’s Disease as a Model of Venous Thrombosis. Open Cardiovasc. Med. J. 2010 23;4:71–7. DOI: 10.2174/1874192401004020071Guzelian G., Norton M.E. Behçet’s syndrome associated with intrauterine growth restriction: a case report and review of the literature. J. Perinatol. 1997;17(4):318–20.Guzelian G., Norton M.E. Behçet’s syndrome associated with intrauterine growth restriction: a case report and review of the literature. J. Perinatol. 1997;17(4):318–20.Barros T., Braga A., Marinho A., Braga J. Behçet’s disease and pregnancy: a retrospective case-control study. Yale J. Biol. Med. 2021;94(4):585–592.Barros T., Braga A., Marinho A., Braga J. Behçet’s disease and pregnancy: a retrospective case-control study. Yale J. Biol. Med. 2021;94(4):585–592.Gungor A.N., Kalkan G., Oguz S., Sen B., Ozoguz P., Takci Z. et al. Behçet disease and pregnancy. Clin. Exp. Obs. Gyn. 2014;41(6): 617–9.Gungor A.N., Kalkan G., Oguz S., Sen B., Ozoguz P., Takci Z. et al. Behçet disease and pregnancy. Clin. Exp. Obs. Gyn. 2014;41(6): 617–9.Chan T.M., Chiou M.J., Kuo C.F. Adverse pregnancy outcomes in women with Behçet’s disease: population-based registry linkage study in Taiwan. Clin. Rheumatol. 2021;40(10):4135–4142. DOI: 10.1007/s10067-021-05688-6Chan T.M., Chiou M.J., Kuo C.F. Adverse pregnancy outcomes in women with Behçet’s disease: population-based registry linkage study in Taiwan. Clin. Rheumatol. 2021;40(10):4135–4142. DOI: 10.1007/s10067-021-05688-6Alekberova1 Z., Goloeva1 R., Lila A. 1 V.A. Nasonova VA. Behcet’s diasease and pregnancy outcomes. Аnn Rheum Dis: Scientific Abstracts of European Congress of Rheumatology. 2022;81(1): 1006.Alekberova1 Z., Goloeva1 R., Lila A. 1 V.A. Nasonova VA. Behcet’s diasease and pregnancy outcomes. Аnn Rheum Dis: Scientific Abstracts of European Congress of Rheumatology. 2022;81(1): 1006.Orgul G., Aktoz F., Beksac M.S. Behcet’s disease and pregnancy: what to expect? J. Obstet. Gynaecol. 2018;38(2):185–188. DOI: 10.1080/01443615.2017.1336614Orgul G., Aktoz F., Beksac M.S. Behcet’s disease and pregnancy: what to expect? J. Obstet. Gynaecol. 2018;38(2):185–188. DOI: 10.1080/01443615.2017.1336614Sims C., Clowse M.E.B. A comprehensive guide for managing the reproductive health of patients with vasculitis. Nat. Rev. Rheumatol. 2022;18(12):711–723. DOI: 10.1038/s41584-022-00842-zSims C., Clowse M.E.B. A comprehensive guide for managing the reproductive health of patients with vasculitis. Nat. Rev. Rheumatol. 2022;18(12):711–723. DOI: 10.1038/s41584-022-00842-zRoss C., D’Souza R., Pagnoux C. Pregnancy Outcomes in Systemic Vasculitides. Curr. Rheumatol. Rep. 2020;22(10):63. DOI: 10.1007/s11926-020-00940-5Ross C., D’Souza R., Pagnoux C. Pregnancy Outcomes in Systemic Vasculitides. Curr. Rheumatol. Rep. 2020;22(10):63. DOI: 10.1007/s11926-020-00940-5

The authors declare that there are no conflicts of interest present.