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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">clinmed</journal-id><journal-title-group><journal-title xml:lang="ru">Клиническая медицина</journal-title><trans-title-group xml:lang="en"><trans-title>Clinical Medicine (Russian Journal)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0023-2149</issn><issn pub-type="epub">2412-1339</issn><publisher><publisher-name>ООО «Медицинское информационное агентство»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.30629/0023-2149-2023-101-7-8-368-375</article-id><article-id custom-type="elpub" pub-id-type="custom">clinmed-592</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ И ЛЕКЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS AND LECTURES</subject></subj-group></article-categories><title-group><article-title>Гангрена Фурнье — мультидисциплинарная проблема гнойно-септической хирургии</article-title><trans-title-group xml:lang="en"><trans-title>Fournier's gangrene аs a multidisciplinary problem of purulent septic surgery</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3974-0781</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Алиев</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Aliyev</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Алиев Садай Агалар оглы  — д-р мед. наук, профессор кафедры хирургических болезней № 1</p><p>AZ 1022, Баку</p></bio><bio xml:lang="en"><p>AZ 1022, Baku</p></bio><email xlink:type="simple">sadayaliev1948@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2848-7370</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Алиев</surname><given-names>Э. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Aliyev</surname><given-names>E. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Алиев Эмиль Садай оглы  – канд. мед. наук</p><p>AZ 1022, Баку</p></bio><bio xml:lang="en"><p>AZ 1022, Baku</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Азербайджанский медицинский университет</institution><country>Азербайджан</country></aff><aff xml:lang="en"><institution>Azerbaijan Medical University</institution><country>Azerbaijan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>22</day><month>09</month><year>2023</year></pub-date><volume>101</volume><issue>7-8</issue><fpage>368</fpage><lpage>375</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Алиев С.А., Алиев Э.С., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Алиев С.А., Алиев Э.С.</copyright-holder><copyright-holder xml:lang="en">Aliyev S.A., Aliyev E.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.clinmedjournal.com/jour/article/view/592">https://www.clinmedjournal.com/jour/article/view/592</self-uri><abstract><p>Статья посвящена актуальной проблеме гнойно-септической хирургии, в ней представлен аналитический обзор систематической литературы, освещающей одну из редких форм некротизирующего фасциита — гангрену Фурнье. С позиции эволюционного подхода изложены исторические вехи формирования научных взглядов на сущность и этиопатогенез болезни, ее эпидемиологию, классификацию, клинику, диагностику и лечение. В контексте дефиниции декларировано, что в современном представлении под понятием «гангрена Фурнье» подразумевается частная (специфическая) модель критических состояний в хирургии, которая характеризуется прогрессирующим гнойно-некротическим поражением и гнилостным распадом фасциальных и мягкотканных структур наружных половых органов, манифестирующих явлениями системного эндотоксикоза, септического шока и высокой летальностью. Постулировано, что в основе патогенетического механизма развития гангрены Фурнье лежит внутрисосудистая инвазия каузативной микрофлоры, следствием которой является диссеминированный тромбоз микроциркуляторного русла поверхностной фасции мошонки. В соответствии с принципами доказательной медицины изложены современные методы диагностики и лечения. Показано, что приоритетом в лечении больных с гангреной Фурнье является неотложное оперативное вмешательство в формате «агрессивной хирургии», главной составляющей которой считается «рукотворная элиминация» некротизированных и нежизнеспособных тканей, достигаемая программированной (этапной) санационной некрэктомией. Рассмотрены вопросы адъювантной терапии с использованием методов лазерной санации, вакуум-терапии раны и гипербарической оксигенации. На основании многофакторного анализа данных современной литературы декларировано, что важным условием, всецело влияющим на исход лечения и прогноз болезни, является мультидисциплинарный подход к решению диагностических и лечебно-тактических задач с участием врачей смежных специальностей (хирурга, колопроктолога, уролога. дерматолога, реаниматолога, радиолога, бактериолога).</p></abstract><trans-abstract xml:lang="en"><p>The article is dedicated to the current problem of pyoseptic surgery, presenting an analytical review of the systematic literature that covers one of the rare forms of necrotizing fasciitis — Fournier’s gangrene. From the perspective of an evolutionary approach, the historical milestones in the formation of scientifi c views on the essence and etiopathogenesis of the disease, its epidemiology, classifi cation, clinical presentation, diagnosis, and treatment are presented. In the context of the defi nition, it is declared that in the modern understanding, “Fournier’s gangrene” implies a particular (specifi c) model of critical conditions in surgery, which is characterized by progressive purulent-necrotic lesions and putrefactive decomposition of fascial and soft tissue structures of the external genitalia, manifesting with systemic endotoxemia, septic shock, and high mortality rates. It is postulated that the intravascular invasion of causative microfl ora is at the basis of the pathogenetic mechanism of Fournier’s gangrene development, resulting in disseminated thrombosis of the microcirculatory bed of the superfi cial fascia of the scrotum. In accordance with the principles of evidence-based medicine, modern methods of diagnosis and treatment are outlined. It is shown that urgent surgical intervention in the format of “aggressive surgery,” with the main component being “manual elimination” of necrotic and non-viable tissues achieved through programmed (staged) sanitation necrectomy, is a priority in the treatment of patients with Fournier’s gangrene. Issues of adjuvant therapy using methods such as laser sanitation, vacuum wound therapy, and hyperbaric oxygenation are discussed. Based on a multifactorial analysis of data from contemporary literature, it is declared that a crucial condition that signifi cantly infl uences treatment outcomes and disease prognosis is a multidisciplinary approach to solving diagnostic and therapeutic tasks involving doctors from related specialties (surgeons, coloproctologists, urologists, dermatologists, intensivists, radiologists, bacteriologists).</p></trans-abstract><kwd-group xml:lang="ru"><kwd>некротизирующий фасциит</kwd><kwd>гангрена Фурнье</kwd><kwd>системный эндотоксикоз</kwd><kwd>сепсис</kwd><kwd>лечение</kwd><kwd>летальность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>necrotizing fasciitis</kwd><kwd>Fournier’s gangrene</kwd><kwd>systemic endotoxemia</kwd><kwd>sepsis</kwd><kwd>treatment</kwd><kwd>mortality</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Linder K.E., Nicolau D.P., Nailor M.D. Epidemiology, treatment and economics of patients presenting to the emergency department for skin and soft tissue infections. 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