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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">clinmed</journal-id><journal-title-group><journal-title xml:lang="ru">Клиническая медицина</journal-title><trans-title-group xml:lang="en"><trans-title>Clinical Medicine (Russian Journal)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0023-2149</issn><issn pub-type="epub">2412-1339</issn><publisher><publisher-name>ООО «Медицинское информационное агентство»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.30629/0023-2149-2023-101-2-3-147-155</article-id><article-id custom-type="elpub" pub-id-type="custom">clinmed-518</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЗАМЕТКИ И НАБЛЮДЕНИЯ ИЗ ПРАКТИКИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>NOTES AND OBSERVATIONS FROM PRACTICE</subject></subj-group></article-categories><title-group><article-title>Поражение легких у пациентки с системной красной волчанкой</article-title><trans-title-group xml:lang="en"><trans-title>Lung lesion in a patient with systemic lupus erythematosus</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7114-435X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Правкина</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Pravkina</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Правкина Екатерина Алексеевна — канд. мед. наук, ассистент кафедры госпитальной терапии с курсом медико-социальной экспертизы</p><p>390026, Рязань</p></bio><bio xml:lang="en"><p>Pravkina Ekaterina A.</p><p>390026, Ryazan</p></bio><email xlink:type="simple">dr.pravkina@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4263-8216</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Баранова</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Baranova</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Баранова Анна Сергеевна — ассистент кафедры анатомии</p><p>390026, Рязань</p></bio><bio xml:lang="en"><p>Baranova Anna S.</p><p>390026, Ryazan</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6658-2072</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Филоненко</surname><given-names>С. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Filonenko</surname><given-names>S. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Филоненко Сергей Павлович — канд. мед. наук, доцент кафедры госпитальной терапии с курсом медико-социальной экспертизы</p><p>390026, Рязань</p></bio><bio xml:lang="en"><p>Filonenko Sergey P.</p><p>390026, Ryazan</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8307-2883</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Молчанов</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Molchanov</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Молчанов Сергей Анатольевич — врачрентгенолог кабинета компьютерной томографии</p><p>390029, Рязань</p></bio><bio xml:lang="en"><p>Molchanov Sergey A.</p><p>390029, Ryazan</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Рязанский государственный медицинский университет им. академика И.П. Павлова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Ryazan State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ООО «Медицинский Центр ЕЛАМЕД»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>ELAMED Medical Center LLC</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>13</day><month>04</month><year>2023</year></pub-date><volume>101</volume><issue>2-3</issue><fpage>147</fpage><lpage>155</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Правкина Е.А., Баранова А.С., Филоненко С.П., Молчанов С.А., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Правкина Е.А., Баранова А.С., Филоненко С.П., Молчанов С.А.</copyright-holder><copyright-holder xml:lang="en">Pravkina E.A., Baranova A.S., Filonenko S.P., Molchanov S.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.clinmedjournal.com/jour/article/view/518">https://www.clinmedjournal.com/jour/article/view/518</self-uri><abstract><p>Системная красная волчанка — хроническое ревматическое аутоиммунное заболевание, которое характеризуется полисистемностью поражения и многообразием клинических проявлений. Она может поражать дыхательную систему, что наиболее часто представлено плевритом или легочной гипертензией. Однако в данной публикации описан клинический случай, в котором поражение легких у пациентки с системной красной волчанкой длительностью более 25 лет проявилось интерстициальным поражением легких (ИПЛ), что более характерно для других ревматических заболеваний, таких как системная склеродермия, болезнь Шегрена. ИПЛ манифестировало нетипичной яркой клинической картиной, прогрессировало и потребовало назначения генно-инженерных биологических препаратов. Их применение осложнилось рецидивирующей мочевой инфекцией, в связи с чем эти препараты были отменены. Особенностью ИПЛ является «стертость» клинической картины, что создает дополнительные трудности в дифференциальной диагностике, особенно в период широкого распространения новой коронавирусной инфекции с учетом сходных клинических проявлений и изменений, обнаруживаемых при компьютерной томографии легких, и приводит к позднему началу патогенетической терапии. В связи с этим особого внимания заслуживает эпизод ухудшения самочувствия пациентки, проявлявшийся клинической картиной и паттерном изменений на компьютерной томограмме, сходными как с прогрессирующем ИПЛ, так и с пневмонией, ассоциированной с новой коронавирусной инфекцией, что осложняло дифференциальную диагностику и тактику ведения.</p></abstract><trans-abstract xml:lang="en"><p>Systemic lupus erythematosus is a chronic rheumatic autoimmune disease characterized by polysystemic lesions and a variety of clinical manifestations. This disease often aff ects the respiratory system, represented mainly by pleurisy or pulmonary hypertension. However, this publication describes a clinical case in which lung damage in a patient who has had systemic lupus erythematosus for over than 25 years, manifested itself as interstitial lung disease (ILD), which is more typical for other rheumatic diseases, such as  diff use scleroderma, Sjogren disease. ILD manifested with an atypically bright clinical picture, progressed and required the prescription of genetically engineered biological drugs. Their use was complicated by recurrent urinary tract infection, and therefore these drugs were withheld. A peculiar feature of ILD is its blurred clinical picture, which causes additional diffi  culties in diff erential diagnosis, especially during the period of widespread new coronavirus infection, taking into account similar clinical manifestations and changes detected by computed tomography of the lungs, so it leads to a late start of pathogenetic therapy. In this regard, the episode of recrudescence of the patient’s condition manifested by a clinical picture and a pattern of changes on a CT scan, similar to both progressive IPL and pneumonia associated with a new coronavirus infection, which complicated diff erential diagnosis and management tactics, deserves special attention.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>системная красная волчанка</kwd><kwd>интерстициальное поражение легких</kwd><kwd>легочная гипертензия</kwd><kwd>синдром Рейно</kwd><kwd>синдром Шегрена</kwd><kwd>ритуксимаб</kwd><kwd>микофенолата мофетил</kwd><kwd>новая коронавирусная инфекция</kwd></kwd-group><kwd-group xml:lang="en"><kwd>systemic lupus erythematosus</kwd><kwd>interstitial lung disease</kwd><kwd>pulmonary hypertension</kwd><kwd>Raynaud syndrome</kwd><kwd>Sjogren syndrome</kwd><kwd>rituximab</kwd><kwd>mycophenolate mofetil</kwd><kwd>coronavirus disease</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Шостак Н. 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