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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">clinmed</journal-id><journal-title-group><journal-title xml:lang="ru">Клиническая медицина</journal-title><trans-title-group xml:lang="en"><trans-title>Clinical Medicine (Russian Journal)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0023-2149</issn><issn pub-type="epub">2412-1339</issn><publisher><publisher-name>ООО «Медицинское информационное агентство»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.30629/0023-2149-2023-101-1-26-31</article-id><article-id custom-type="elpub" pub-id-type="custom">clinmed-496</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ И ЛЕКЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS AND LECTURES</subject></subj-group></article-categories><title-group><article-title>Артериальная гипертензия при COVID-19</article-title><trans-title-group xml:lang="en"><trans-title>Arterial hypertension in COVID-19</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6665-8601</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Змитрукевич</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Zmitrukevich</surname><given-names>А. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Змитрукевич Андрей Станиславович — врач общей практики</p><p>119331, Москва</p></bio><bio xml:lang="en"><p>Zmitrukevich Andrey S.</p><p>119331, Moscow</p></bio><email xlink:type="simple">andrey1881889@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9183-3216</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мамедова</surname><given-names>А. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Mamedova</surname><given-names>A. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мамедова Анастасия Евгеньевна — ассистент кафедры биологической химии</p><p>230009, Гродно</p></bio><bio xml:lang="en"><p>Mamedova Anastasia E.</p><p>230009, Grodno</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБУЗ «Городская поликлиника № 11 Департамента здравоохранения города Москвы»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>City Polyclinic No. 11 of the Moscow Department of Healthcare</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Учреждение образования «Гродненский государственный медицинский университет»</institution><country>Беларусь</country></aff><aff xml:lang="en"><institution>Grodno State Medical University</institution><country>Belarus</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>26</day><month>03</month><year>2023</year></pub-date><volume>101</volume><issue>1</issue><fpage>26</fpage><lpage>31</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Змитрукевич А.С., Мамедова А.Е., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Змитрукевич А.С., Мамедова А.Е.</copyright-holder><copyright-holder xml:lang="en">Zmitrukevich А.S., Mamedova A.E.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.clinmedjournal.com/jour/article/view/496">https://www.clinmedjournal.com/jour/article/view/496</self-uri><abstract><p>Актуальность. Вирус SARS-CoV-2 стал причиной пандемии COVID-19. Артериальная гипертензия (АГ) при COVID-19 играет важную роль в прогнозе заболеваемости и смертности. Цель. Краткий отчет о влиянии COVID-19 на АГ. Обсуждение. Заболевание COVID-19 достаточно часто сопровождается изменениями со стороны сердечно-сосудистой системы. АГ является одной из самых распространенных сопутствующих заболеваний. Множество исследований доказывают связь АГ с COVID-19. Основными механизмами увеличения показателей артериального давления могут быть увеличение концентрации ангиотензина II в крови, взаимодействие SARS-CoV-2 с рецепторами АПФ2 мембраны клеток инфицированного, прямое и косвенное воздействие на эндотелий, снижение уровня сосудорасширяющих факторов (оксида азота (NO) и простациклина), психологическое давление пандемией COVID-19. Заключение. Терапевты и врачи общей практики должны знать о рисках развития АГ при ведении пациентов с COVID-19, а также диспансеризации населения.</p></abstract><trans-abstract xml:lang="en"><p>Background. The SARS-CoV-2 virus caused the COVID-19 pandemic. Arterial hypertension in COVID-19 plays an important role in the prognosis of morbidity and mortality. Objective. A brief report on the effect of COVID-19 on arterial hypertension. Discussion. COVID-19 is often accompanied by changes in the cardiovascular system. Arterial hypertension is one of the most common comorbid conditions. A lot of studies have proved the connection of hypertension with COVID-19. The main mechanisms for increasing blood pressure indicators may be: an increase in the concentration of angiotensin II in the blood, the interaction of SARS-CoV-2 with the APF2 receptors of the infected cell membrane, direct and indirect effects on the endothelium, a decrease in the level of vasodilating factors (nitric oxide (NO) and prostacyclin), psychological pressure by the COVID-19 pandemic. Conclusions. Physicians and general practitioners should be aware of hypertension in the management of patients with COVID-19, and the prophylactic medical examination of the population.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>артериальная гипертензия</kwd><kwd>гипокалиемия</kwd><kwd>ренин-ангиотензин</kwd><kwd>COVID-19</kwd><kwd>SARS-CoV-2</kwd></kwd-group><kwd-group xml:lang="en"><kwd>hypertension</kwd><kwd>hypokalemia</kwd><kwd>renin-angiotensin</kwd><kwd>COVID-19</kwd><kwd>SARS-CoV-2</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ji W., Wang W., Zhao X. et al. Cross-species transmission of the newly identifi ed coronavirus 2019-nCoV. Journal of medical virology. 2020;92(4):433–440. DOI: 10.1002/jmv.25682</mixed-citation><mixed-citation xml:lang="en">Ji W., Wang W., Zhao X. et al. Cross-species transmission of the newly identifi ed coronavirus 2019-nCoV. Journal of medical virology. 2020;92(4):433–440. DOI: 10.1002/jmv.25682</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Zmitrukevich A.S. Cardiovascular Changes in COVID19. Acta Scientifi c Medical Sciences. 2022;6(2):32–39. DOI: 10.31080/ASMS.2022.S02.0007</mixed-citation><mixed-citation xml:lang="en">Zmitrukevich A.S. Cardiovascular Changes in COVID19. Acta Scientifi c Medical Sciences. 2022;6(2):32–39. DOI: 10.31080/ASMS.2022.S02.0007</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Rodriguez-Iturbe B., Pons H., Johnson R.J. Role of the immune system in hypertension. Physiological reviews. 2017;97(3):1127–1164. DOI: 10.1152/physrev.00031.2016</mixed-citation><mixed-citation xml:lang="en">Rodriguez-Iturbe B., Pons H., Johnson R.J. Role of the immune system in hypertension. Physiological reviews. 2017;97(3):1127–1164. DOI: 10.1152/physrev.00031.2016</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Bepouka B., Situakibanza H., Sangare M. et al. Mortality associated with COVID-19 and hypertension in sub‐Saharan Africa. A systematic review and meta‐analysis. Journal of Clinical Hypertension. 2022;24(2):99–105. DOI: 10.1111/jch.14417</mixed-citation><mixed-citation xml:lang="en">Bepouka B., Situakibanza H., Sangare M. et al. Mortality associated with COVID-19 and hypertension in sub‐Saharan Africa. A systematic review and meta‐analysis. Journal of Clinical Hypertension. 2022;24(2):99–105. DOI: 10.1111/jch.14417</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Yoshida Y., Gillet S.A., Brown M.I. et al. Clinical characteristics and outcomes in women and men hospitalized for coronavirus disease 2019 in New Orleans. Biology of sex Diff erences. 2021;12(1):1–1. DOI: 10.1186/s13293-021-00359-2</mixed-citation><mixed-citation xml:lang="en">Yoshida Y., Gillet S.A., Brown M.I. et al. Clinical characteristics and outcomes in women and men hospitalized for coronavirus disease 2019 in New Orleans. Biology of sex Diff erences. 2021;12(1):1–1. DOI: 10.1186/s13293-021-00359-2</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Richardson S., Hirsch J.S., Narasimhan M. et al. Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area. JAMA. 2020;323(20):2052–2059. DOI: 10.1001/jama.2020.6775</mixed-citation><mixed-citation xml:lang="en">Richardson S., Hirsch J.S., Narasimhan M. et al. Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area. JAMA. 2020;323(20):2052–2059. DOI: 10.1001/jama.2020.6775</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Wu Z., McGoogan J.M. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA. 2020;323(13):1239–1242. DOI: 10.1001/jama.2020.2648</mixed-citation><mixed-citation xml:lang="en">Wu Z., McGoogan J.M. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA. 2020;323(13):1239–1242. DOI: 10.1001/jama.2020.2648</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Williamson E.J., Walker A.J., Bhaskaran K. et al. Factors associated with COVID-19-related death using OpenSAFELY. Nature. 2020;584(7821):430–436. DOI: 10.1038/s41586-020-2521-4</mixed-citation><mixed-citation xml:lang="en">Williamson E.J., Walker A.J., Bhaskaran K. et al. Factors associated with COVID-19-related death using OpenSAFELY. Nature. 2020;584(7821):430–436. DOI: 10.1038/s41586-020-2521-4</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Luan J., Lu Y., Jin X., Zhang L. Spike protein recognition of mammalian ACE2 predicts the host range and an optimized ACE2 for SARSCoV-2 infection. Biochemical and biophysical research communications. 2020;526(1):165–169. DOI: 10.1016/j.bbrc.2020.03.047</mixed-citation><mixed-citation xml:lang="en">Luan J., Lu Y., Jin X., Zhang L. Spike protein recognition of mammalian ACE2 predicts the host range and an optimized ACE2 for SARSCoV-2 infection. Biochemical and biophysical research communications. 2020;526(1):165–169. DOI: 10.1016/j.bbrc.2020.03.047</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Chen J., Jiang Q., Xia X. et al. Individual variation of the SARS-CoV-2 receptor ACE2 gene expression and regulation. Aging cell. 2020;19(7):e13168. DOI: 10.1111/acel.13168</mixed-citation><mixed-citation xml:lang="en">Chen J., Jiang Q., Xia X. et al. Individual variation of the SARS-CoV-2 receptor ACE2 gene expression and regulation. Aging cell. 2020;19(7):e13168. DOI: 10.1111/acel.13168</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Wei C., Wan L., Yan Q. et al. HDL-scavenger receptor B type 1 facilitates SARS-CoV-2 entry. Nature metabolism. 2020;2(12):1391– 1400. DOI: 10.1038/s42255-020-00324-0</mixed-citation><mixed-citation xml:lang="en">Wei C., Wan L., Yan Q. et al. HDL-scavenger receptor B type 1 facilitates SARS-CoV-2 entry. Nature metabolism. 2020;2(12):1391– 1400. DOI: 10.1038/s42255-020-00324-0</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Shen W.J., Asthana S., Kraemer F.B., Azhar S. Thematic review series: lipid transfer proteins scavenger receptor B type 1: expression, molecular regulation, and cholesterol transport function. Journal of Lipid Research. 2018;59(7):1114–1131. DOI: 10.1194/jlr.R083121</mixed-citation><mixed-citation xml:lang="en">Shen W.J., Asthana S., Kraemer F.B., Azhar S. Thematic review series: lipid transfer proteins scavenger receptor B type 1: expression, molecular regulation, and cholesterol transport function. Journal of Lipid Research. 2018;59(7):1114–1131. DOI: 10.1194/jlr.R083121</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Shen W.J, Azhar S., Kraemer F.B. SR-B1: a unique multifunctional receptor for cholesterol infl ux and effl ux. Annual review of physiology. 2018;80:95. DOI: 10.1146/annurev-physiol-021317-12155.0</mixed-citation><mixed-citation xml:lang="en">Shen W.J, Azhar S., Kraemer F.B. SR-B1: a unique multifunctional receptor for cholesterol infl ux and effl ux. Annual review of physiology. 2018;80:95. DOI: 10.1146/annurev-physiol-021317-12155.0</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Ibrahim M.M., Damasceno A. Hypertension in developing countries. Lancet. 2012;380(9841):611–619. DOI: 10.1016/S0140-6736(12)60861-7</mixed-citation><mixed-citation xml:lang="en">Ibrahim M.M., Damasceno A. Hypertension in developing countries. Lancet. 2012;380(9841):611–619. DOI: 10.1016/S0140-6736(12)60861-7</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Danilczyk U., Penninger J.M. Angiotensin-converting enzyme II in the heart and the kidney. Circulation research. 2006;98(4):463–471. DOI: 10.1161/01.RES.0000205761.22353.5f</mixed-citation><mixed-citation xml:lang="en">Danilczyk U., Penninger J.M. Angiotensin-converting enzyme II in the heart and the kidney. Circulation research. 2006;98(4):463–471. DOI: 10.1161/01.RES.0000205761.22353.5f</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Tipnis S.R., Hooper N.M., Hyde R. et al. A human homolog of angiotensin-converting enzyme: cloning and functional expression as a captopril-insensitive carboxypeptidase. Journal of Biological Che mistry. 2000;275(43):33238–33243. DOI: 10.1074/jbc.M002615200</mixed-citation><mixed-citation xml:lang="en">Tipnis S.R., Hooper N.M., Hyde R. et al. A human homolog of angiotensin-converting enzyme: cloning and functional expression as a captopril-insensitive carboxypeptidase. Journal of Biological Che mistry. 2000;275(43):33238–33243. DOI: 10.1074/jbc.M002615200</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Patel S., Rauf A., Khan H., Abu-Izneid T. Renin-angiotensin-aldosterone (RAAS): The ubiquitous system for homeostasis and pathologies. Biomedicine &amp; Pharmacotherapy. 2017;94:317–325. DOI: 10.1016/j.biopha.2017.07.091</mixed-citation><mixed-citation xml:lang="en">Patel S., Rauf A., Khan H., Abu-Izneid T. Renin-angiotensin-aldosterone (RAAS): The ubiquitous system for homeostasis and pathologies. Biomedicine &amp; Pharmacotherapy. 2017;94:317–325. DOI: 10.1016/j.biopha.2017.07.091</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Литвинов А.С., Савин А.В., Кухтина А.А. Долгосрочные перспективы внелегочного персистирования коронавируса SARS-CoV-2. Медицина. 2020;8(1):51–73.</mixed-citation><mixed-citation xml:lang="en">Litvinov A.S., Savin A.V., Kuhtina A.A. Long-term prospects of extrapulmonary persistence of SARS-CoV-2 coronavirus. Medicine. 2020;8(1):51–73. (In Russian). DOI: 10.29234/2308-9113-2020-8-1-51-73</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Castoldi G., Carletti R., Ippolito S. et al. Angiotensin Type 2 and Mas Receptor Activation Prevents Myocardial Fibrosis and Hypertrophy through the Reduction of Infl ammatory Cell Infi ltration and Local Sympathetic Activity in Angiotensin II-Dependent Hypertension. International Journal of Molecular Sciences. 2021;22(24):13678. DOI: 10.3390/ijms222413678</mixed-citation><mixed-citation xml:lang="en">Castoldi G., Carletti R., Ippolito S. et al. Angiotensin Type 2 and Mas Receptor Activation Prevents Myocardial Fibrosis and Hypertrophy through the Reduction of Infl ammatory Cell Infi ltration and Local Sympathetic Activity in Angiotensin II-Dependent Hypertension. International Journal of Molecular Sciences. 2021;22(24):13678. DOI: 10.3390/ijms222413678</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Taylor P.C., Adams A.C., Huff ord M.M. et al. Neutralizing monoclonal antibodies for treatment of COVID-19. Nature Reviews Immunology. 2021;21(6):382–393. DOI: 10.1038/s41577-021-00542-x</mixed-citation><mixed-citation xml:lang="en">Taylor P.C., Adams A.C., Huff ord M.M. et al. Neutralizing monoclonal antibodies for treatment of COVID-19. Nature Reviews Immunology. 2021;21(6):382–393. DOI: 10.1038/s41577-021-00542-x</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Chappell MC, Allred AJ, Ferrario CM. Pathways of angiotensin‐(1– 7) metabolism in the kidney. Nephrology Dialysis Transplantation. 2001;16(1):22–26. DOI: 10.1093/ndt/16.suppl_1.22.</mixed-citation><mixed-citation xml:lang="en">Chappell MC, Allred AJ, Ferrario CM. Pathways of angiotensin‐(1– 7) metabolism in the kidney. Nephrology Dialysis Transplantation. 2001;16(1):22–26. DOI: 10.1093/ndt/16.suppl_1.22.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Ren L., Yu S., Xu W. et al. Lack of association of antihypertensive drugs with the risk and severity of COVID-19: A meta-analysis. Journal of Сardiology. 2021;77(5):482–491. DOI: 10.1016/j.jjcc.2020.10.015</mixed-citation><mixed-citation xml:lang="en">Ren L., Yu S., Xu W. et al. Lack of association of antihypertensive drugs with the risk and severity of COVID-19: A meta-analysis. Journal of Сardiology. 2021;77(5):482–491. DOI: 10.1016/j.jjcc.2020.10.015</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang P., Zhu L., Cai J. et al. Association of inpatient use of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers with mortality among patients with hypertension hospitalized with COVID-19. Circulation Кesearch. 2020;126(12):1671– 1681. DOI: 10.1161/CIRCRESAHA.120.317134</mixed-citation><mixed-citation xml:lang="en">Zhang P., Zhu L., Cai J. et al. Association of inpatient use of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers with mortality among patients with hypertension hospitalized with COVID-19. Circulation Кesearch. 2020;126(12):1671– 1681. DOI: 10.1161/CIRCRESAHA.120.317134</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Alfaleh M.A., Zawawi A., Al-Amri S.S., Hashem A.M. David versus goliath: ACE2-Fc receptor traps as potential SARS-CoV-2 inhibitors. MAbs. 2022;14(1):2057832. DOI: 10.1080/19420862.2022.2057832</mixed-citation><mixed-citation xml:lang="en">Alfaleh M.A., Zawawi A., Al-Amri S.S., Hashem A.M. David versus goliath: ACE2-Fc receptor traps as potential SARS-CoV-2 inhibitors. MAbs. 2022;14(1):2057832. DOI: 10.1080/19420862.2022.2057832</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Imai Y., Kuba K., Rao S. et al. Angiotensin-converting enzyme 2 protects from severe acute lung failure. Nature. 2005;436(7047):112– 116. DOI: 10.1038/nature03712</mixed-citation><mixed-citation xml:lang="en">Imai Y., Kuba K., Rao S. et al. Angiotensin-converting enzyme 2 protects from severe acute lung failure. Nature. 2005;436(7047):112– 116. DOI: 10.1038/nature03712</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Liu Y., Yang Y., Zhang C. et al. Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury. Science China Life Sciences. 2020;63(3):364–374. DOI: 10.1007/s11427-020-1643-8</mixed-citation><mixed-citation xml:lang="en">Liu Y., Yang Y., Zhang C. et al. Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury. Science China Life Sciences. 2020;63(3):364–374. DOI: 10.1007/s11427-020-1643-8</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Zoufaly A., Poglitsch M., Aberle J.H. et al. Human recombinant soluble ACE2 in severe COVID-19. The Lancet Respiratory Medicine. 2020;8(11):1154–1158. DOI: 10.1016/S2213-2600(20)30418-5</mixed-citation><mixed-citation xml:lang="en">Zoufaly A., Poglitsch M., Aberle J.H. et al. Human recombinant soluble ACE2 in severe COVID-19. The Lancet Respiratory Medicine. 2020;8(11):1154–1158. DOI: 10.1016/S2213-2600(20)30418-5</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Patel V.B., Parajuli N., Oudit G.Y. Role of angiotensin-converting enzyme 2 (ACE2) in diabetic cardiovascular complications. Clinical science. 2014;126(7):471–482. DOI: 10.1042/CS20130344</mixed-citation><mixed-citation xml:lang="en">Patel V.B., Parajuli N., Oudit G.Y. Role of angiotensin-converting enzyme 2 (ACE2) in diabetic cardiovascular complications. Clinical science. 2014;126(7):471–482. DOI: 10.1042/CS20130344</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Berger R.C., Vassallo P.F., Crajoinas R.D. et al. Renal eff ects and underlying molecular mechanisms of long-term salt content diets in spontaneously hypertensive rats. PLoS One. 2015;10(10):e0141288. DOI: 10.1371/journal.pone.0141288</mixed-citation><mixed-citation xml:lang="en">Berger R.C., Vassallo P.F., Crajoinas R.D. et al. Renal eff ects and underlying molecular mechanisms of long-term salt content diets in spontaneously hypertensive rats. PLoS One. 2015;10(10):e0141288. DOI: 10.1371/journal.pone.0141288</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Varga Z., Flammer A.J., Steiger P. et al. Endothelial cell infection and endotheliitis in COVID-19. The Lancet. 2020;395(10234):1417– 1418. DOI: 10.1016/S0140-6736(20)30937-5</mixed-citation><mixed-citation xml:lang="en">Varga Z., Flammer A.J., Steiger P. et al. Endothelial cell infection and endotheliitis in COVID-19. The Lancet. 2020;395(10234):1417– 1418. DOI: 10.1016/S0140-6736(20)30937-5</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Kang S., Tanaka T., Inoue H. et al. IL-6 trans-signaling induces plasminogen activator inhibitor-1 from vascular endothelial cells in cytokine release syndrome. Proceedings of the National Academy of Sciences. 2020;117(36):22351–22356. DOI: 10.1073/pnas.2010229117</mixed-citation><mixed-citation xml:lang="en">Kang S., Tanaka T., Inoue H. et al. IL-6 trans-signaling induces plasminogen activator inhibitor-1 from vascular endothelial cells in cytokine release syndrome. Proceedings of the National Academy of Sciences. 2020;117(36):22351–22356. DOI: 10.1073/pnas.2010229117</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Chang J.C. COVID-19 Sepsis: pathogenesis and endothelial molecular mechanisms based on “two-path unifying theory” of hemostasis and endotheliopathy-associated vascular microthrombotic disease, and proposed therapeutic approach with antimicrothrombotic therapy. Vascular Health and Risk Management. 2021;17:273–298. DOI: 10.2147/VHRM.S299357</mixed-citation><mixed-citation xml:lang="en">Chang J.C. COVID-19 Sepsis: pathogenesis and endothelial molecular mechanisms based on “two-path unifying theory” of hemostasis and endotheliopathy-associated vascular microthrombotic disease, and proposed therapeutic approach with antimicrothrombotic therapy. Vascular Health and Risk Management. 2021;17:273–298. DOI: 10.2147/VHRM.S299357</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Cooke J.P., Connor J.H., Jain A. Acute and chronic cardiovascular manifestations of COVID-19: role for endotheliopathy. Methodist DeBakey Сardiovascular Journal. 2021;17(5):53–62. DOI: 10.14797/mdcvj.1044</mixed-citation><mixed-citation xml:lang="en">Cooke J.P., Connor J.H., Jain A. Acute and chronic cardiovascular manifestations of COVID-19: role for endotheliopathy. Methodist DeBakey Сardiovascular Journal. 2021;17(5):53–62. DOI: 10.14797/mdcvj.1044</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Chang J.C. Acute respiratory distress syndrome as an organ phenotype of vascular microthrombotic disease: based on hemostatic theory and endothelial molecular pathogenesis. Clinical and Applied Thrombosis/Hemostasis. 2019;25:1076029619887437. DOI: 10.1177/1076029619887437</mixed-citation><mixed-citation xml:lang="en">Chang J.C. Acute respiratory distress syndrome as an organ phenotype of vascular microthrombotic disease: based on hemostatic theory and endothelial molecular pathogenesis. Clinical and Applied Thrombosis/Hemostasis. 2019;25:1076029619887437. DOI: 10.1177/1076029619887437</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Tofano R.J., Barbalho S.M., Bechara M.D. et al. Hypertension, C reactive protein and metabolic profi le: what is the scenario in patients undergoing arteriography? Journal of clinical and diagnostic research. 2017;11(8):BC19–BC23. DOI: 10.7860/JCDR/2017/26595.10456</mixed-citation><mixed-citation xml:lang="en">Tofano R.J., Barbalho S.M., Bechara M.D. et al. Hypertension, C reactive protein and metabolic profi le: what is the scenario in patients undergoing arteriography? Journal of clinical and diagnostic research. 2017;11(8):BC19–BC23. DOI: 10.7860/JCDR/2017/26595.10456</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Karakoyun I., Colak A., Turken M. et al. Diagnostic utility of C-reactive protein to albumin ratio as an early warning sign in hospitalized severe COVID-19 patients. International immunopharmacology. 2021;91:107285. DOI: 10.1016/j.intimp.2020.107285</mixed-citation><mixed-citation xml:lang="en">Karakoyun I., Colak A., Turken M. et al. Diagnostic utility of C-reactive protein to albumin ratio as an early warning sign in hospitalized severe COVID-19 patients. International immunopharmacology. 2021;91:107285. DOI: 10.1016/j.intimp.2020.107285</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Zeng F., Huang Y., Guo Y. et al. Association of infl ammatory markers with the severity of COVID-19: a meta-analysis. International Journal of Infectious Diseases. 2020;96:467–474. DOI: 10.1016/j.ijid.2020.05.055</mixed-citation><mixed-citation xml:lang="en">Zeng F., Huang Y., Guo Y. et al. Association of infl ammatory markers with the severity of COVID-19: a meta-analysis. International Journal of Infectious Diseases. 2020;96:467–474. DOI: 10.1016/j.ijid.2020.05.055</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Roohafza H., Sattari N., Nouri F. et al. Do any kinds of perceived stressors lead to hypertension? A longitudinal cohort study. Hypertension Research. 2022;45(6):1058–1066. DOI: 10.1038/s41440-022-00895-3</mixed-citation><mixed-citation xml:lang="en">Roohafza H., Sattari N., Nouri F. et al. Do any kinds of perceived stressors lead to hypertension? A longitudinal cohort study. Hypertension Research. 2022;45(6):1058–1066. DOI: 10.1038/s41440-022-00895-3</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Burtscher J., Burtscher M., Millet G.P. (Indoor) isolation, stress and physical inactivity: vicious circles accelerated by Covid-19? Scandinavian journal of medicine &amp; science in sports. 2020;30(8):1544– 1545. DOI: 10.1111/sms.13706</mixed-citation><mixed-citation xml:lang="en">Burtscher J., Burtscher M., Millet G.P. (Indoor) isolation, stress and physical inactivity: vicious circles accelerated by Covid-19? Scandinavian journal of medicine &amp; science in sports. 2020;30(8):1544– 1545. DOI: 10.1111/sms.13706</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Kobayashi K., Chin K., Umezawa S. et al. Infl uence of stress induced by the fi rst announced state of emergency due to coronavirus disease 2019 on outpatient blood pressure management in Japan. Hypertension Research. 2022;45(4):675–685. DOI: 10.1038/s41440-021-00832-w</mixed-citation><mixed-citation xml:lang="en">Kobayashi K., Chin K., Umezawa S. et al. Infl uence of stress induced by the fi rst announced state of emergency due to coronavirus disease 2019 on outpatient blood pressure management in Japan. Hypertension Research. 2022;45(4):675–685. DOI: 10.1038/s41440-021-00832-w</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Bozzani A., Arici V., Ticozzelli G. et al. Reduced Vascular Practice and Increased Cardiovascular Mortality for COVID-19–Negative Patients. Journal of Surgical Research. 2022;272:146–152. DOI: 10.1016/j.jss.2021.11.014</mixed-citation><mixed-citation xml:lang="en">Bozzani A., Arici V., Ticozzelli G. et al. Reduced Vascular Practice and Increased Cardiovascular Mortality for COVID-19–Negative Patients. Journal of Surgical Research. 2022;272:146–152. DOI: 10.1016/j.jss.2021.11.014</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Wang X., Gao H., Zhang Z. et al. Eff ect of the COVID-19 pandemic on complications and mortality of patients with cardiac surgery. Journal of Cardiothoracic Surgery. 2021;16(1):1–9. DOI: 10.1186/s13019-021-01744-z</mixed-citation><mixed-citation xml:lang="en">Wang X., Gao H., Zhang Z. et al. Eff ect of the COVID-19 pandemic on complications and mortality of patients with cardiac surgery. Journal of Cardiothoracic Surgery. 2021;16(1):1–9. DOI: 10.1186/s13019-021-01744-z</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Fanton L., Nahmani I., Epain M. et al. Forensic autopsy-confi rmed COVID-19-induced out-of-hospital cardiac arrest. Annals of Translational Medicine. 2021;9(23):1715. DOI: 10.21037/atm-21-3918</mixed-citation><mixed-citation xml:lang="en">Fanton L., Nahmani I., Epain M. et al. Forensic autopsy-confi rmed COVID-19-induced out-of-hospital cardiac arrest. Annals of Translational Medicine. 2021;9(23):1715. DOI: 10.21037/atm-21-3918</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Nia H.S., Long She L., Kaur H. et al. A predictive study between anxiety and fear of COVID-19 with psychological behavior response: the mediation role of perceived stress. Frontiers in Psychiatry. 2022;13:851212. DOI: 10.3389/fpsyt.2022.851212</mixed-citation><mixed-citation xml:lang="en">Nia H.S., Long She L., Kaur H. et al. A predictive study between anxiety and fear of COVID-19 with psychological behavior response: the mediation role of perceived stress. Frontiers in Psychiatry. 2022;13:851212. DOI: 10.3389/fpsyt.2022.851212</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
