clinmedКлиническая медицинаClinical Medicine (Russian Journal)0023-21492412-1339ООО «Медицинское информационное агентство»10.30629/0023-2149-2022-100-11-12-540-545clinmed-468Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESПлазма, богатая тромбоцитами, в лечении склероатрофического лихена гениталийPlatelet-rich plasma in the treatment of scleroatrophic lichen of the genitalshttps://orcid.org/0000-0003-2056-9803ПарыгинаО. В.ParyginaO. V.

Парыгина Ольга Владимировна — ассистент кафедры инфекционных болезней Института медицинского образования; врач-дерматовенеролог

197183, Санкт-Петербург197341, Санкт-Петербург

Parygina Olga V.

197183, St. Petersburg197341, St. Petersburg

olga.parygina@bk.ruhttps://orcid.org/0000-0003-0816-8038ОганесянМ. В.OganesyanM. V.

Оганесян Марианна Вигеновна — ассистент кафедры инфекционных болезней, эпидемиологии и дерматовенерологии

199034, Санкт-Петербург

Oganesyan Marianna V.

199034, St. Petersburg

https://orcid.org/0000-0002-8138-1639ШинН. В.ShinN. V.

Шин Наталья Валентиновна — канд. мед. наук, доцент кафедры инфекционных болезней, эпидемиологии и дерматовенерологии

199034, Санкт-Петербург

Shin Natalia V.

199034, St. Petersburg

https://orcid.org/0000-0001-8584-615XСмирноваИ. О.SmirnovaI. O.

Смирнова Ирина Олеговна — д-р мед. наук, профессор кафедры инфекционных болезней, эпидемиологии и дерматовенерологии; врач-дерматовенеролог

199034, Санкт-Петербург192102, Санкт-Петербург

Smirnova Irina O.

199034, St. Petersburg192102, St. Petersburg

ООО «Лахта клиника»; ФГБУ «НМИЦ им. В.А. Алмазова» Минздрава России, Институт медицинского образованияРоссияLahta Clinic; Federal State Budgetary Institution “Almazov National Medical Research Centre”, Institute of Medical EducationRussian FederationФГБОУ ВО «Санкт-Петербургский государственный университет»РоссияSt. Petersburg State UniversityRussian FederationФГБОУ ВО «Санкт-Петербургский государственный университет»; ГБУЗ «Городской кожно-венерологический диспансер»РоссияSt. Petersburg State University; City Skin and Venereological DispensaryRussian Federation20221701202310011-12540545Copyright © Парыгина О.В., Оганесян М.В., Шин Н.В., Смирнова И.О., 20232023Парыгина О.В., Оганесян М.В., Шин Н.В., Смирнова И.О.Parygina O.V., Oganesyan M.V., Shin N.V., Smirnova I.O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.clinmedjournal.com/jour/article/view/468

В статье проводится сравнительный анализ имеющихся на сегодняшний день исследований, посвященных применению плазмы, насыщенной тромбоцитами (PRP), для лечения склероатрофического лихена (САЛ) аногенитальной области. Всего в анализ включено 9 статей, посвященных эффективности применения PRP у пациентов с САЛ гениталий. Статья включает в себя перечисление протоколов исследования и методов оценки эффективности терапии. В большинстве приводимых исследований отмечается хороший терапевтический эффект плазмы для лечения заболевания. PRP может быть использована для быстрого разрешения субъективных симптомов и уменьшения воспаления, а также для лечения синехий и рубцовых состояний. Однако до сих пор не изучен ряд вопросов, касающихся механизма действия плазмы, комбинированного лечения плазмой, насыщенной тромбоцитами, и топическими глюкокортикостероидами. Необходимо проведение дополнительных исследований, которые помогут решить вопросы количества необходимых процедур, интервала между процедурами, и также необходима разработка критериев оценки эффективности терапии, в том числе достоверных, таких как оценка гистологической картины.

The article provides comparative analysis of the current studies on the use of platelet-rich plasma (PRP) for the treatment of lichen sclerosus. The analysis includes 9 articles on efficiency of PRP in patients with genital lichen sclerosus. The article includes a listing of research and methods for evaluating the effect of therapy protocols. Most of the studies have shown a good therapeutic effect of the disease treatment with platelet-rich plasma. PRP may be used to quickly resolve subjective symptoms and reduce inflammation, as well as to treat synechia and cicatricial conditions. However, a problem concerning the mechanism of PRP, combined therapy with PRP, and topical steroids, has not been studied yet. It is necessary to conduct additional studies that will help to determine the number of procedures, and the interval between them. It is also necessary to develop criteria for evaluating the therapy effect, which includes histological examination.

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The authors declare that there are no conflicts of interest present.