References

clinmed

Клиническая медицина

Clinical Medicine (Russian Journal)

0023-21492412-1339

ООО «Медицинское информационное агентство»

10.30629/0023-2149-2022-100-9-10-425-431

clinmed-439

Research Article

ОБЗОРЫ И ЛЕКЦИИ

REVIEWS AND LECTURES

Клиническая реализация анатомо-физиологических свойств синоатриального узла

Clinical realization of anatomical and physiological properties of the sinoatrial node

https://orcid.org/0000-0002-8552-6727

Милюков

В. Е.

Milyukov

V. E.

Милюков Владимир Ефимович — доктор медицинских наук, профессор, профессор кафедры анатомии человека лечебного факультета.

117997, Москва

Milyukov Vladimir Е.

117997, Moscow

https://orcid.org/0000-0001-8445-3688

Брюханов

В. А.

Bryukhanov

V. A.

Брюханов Валерий Александрович — студент Международной школы «Медицина будущего».

119991, Москва

Valery A. Bryukhanov

119991 Moscow

bryuhanov02@mail.ru

https://orcid.org/0000-0003-2190-6648

Нгуен

К. К.

Nguyen

С. С.

Нгуен Као Кыонг — кандидат медицинских наук, декан факультета фармако-медсестринского дела.

Далат

Nguyen Cao Cuong

Dalat

ФГАОУ ВО Российский национальный исследовательский медицинский университет им. Н.И. Пирогова МинздраваРоссияPirogov Russian National Research Medical University (Pirogov Medical University)Russian Federation

ФГАОУ ВО Первый Московский государственный медицинский университет им. И.М. Сеченова Минздрава России (Сеченовский Университет)РоссияI.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)Russian Federation

Университет им. ЙерсенаВьетнамYersin UniversityViet Nam

2022

13122022

1009-10425431

2022

Милюков В.Е., Брюханов В.А., Нгуен К.К.

Milyukov V.E., Bryukhanov V.A., Nguyen С.С.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.clinmedjournal.com/jour/article/view/439

Заболевания синоатриального узла (СУ) характеризуются его неспособностью выполнять функцию доминирующего водителя ритма. В настоящем обзоре приведены данные последних исследований анатомии и физиологии СУ, которые демонстрируют наличие структурной и функциональной неоднородности СУ и его компонентов, описано строение и функция проводящих внутриузловых путей, «новой околоузловой области», а также обсуждается явление сдвига места генерации возбуждения и наличие «неактивного режима» работы кардиомиоцитов. Авторами критически обсуждены генетические механизмы развития синдрома слабости синусового узла (СССУ), обоснованы мультидисциплинарный подход и дальнейшее проведение анатомо-морфологических и физиологических исследований, которые играют принципиальную роль в разработке терапии и диагностики связанных заболеваний.

Diseases of the sinoatrial node (SАN) are characterized by its inability to perform the function of the dominant pacemaker. This review presents data from recent studies of the anatomy and physiology of the SАN, which demonstrate the presence of structural and functional heterogeneity of the SAN and its components, describes the structure and function of the conducting intra-nodal pathways, the “novel paranodal area”, and also discusses the phenomenon of a shift in the site of excitation generation and the presence of a “non-firing mode” of cardiomyocytes. The authors critically discussed the genetic mechanisms of the development of sick sinus node syndrome (SSS), justified a multidisciplinary approach and further anatomical, morphological and physiological studies that play a fundamental role in the development of therapy and diagnosis of related diseases.

синоатриальный узелсиндром слабости синусового узладисфункция синусового узла

sinoatrial nodesick sinus node syndromesinus node dysfunction

Исследование не имело спонсорской поддержки

The study had no sponsorship

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The authors declare that there are no conflicts of interest present.