clinmedКлиническая медицинаClinical Medicine (Russian Journal)0023-21492412-1339ООО «Медицинское информационное агентство»10.30629/0023-2149-2022-100-7-8-341-345clinmed-422Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESПричины, факторы риска, диагностика и лечение желудочно-кишечных кровотечений у больных новой коронавирусной инфекцией (COVID-19)Сauses, risk factors, diagnostics and treatment of gastrointestinal bleeding in patients with a novel coronavirus infection (COVID-19)https://orcid.org/0000-0002-1395-9566ШептулинА. А.SheptulinA. A.

Шептулин Аркадий Александрович — д-р мед. наук, профессор кафедры пропедевтики внутренних болезней, гастроэнтерологии и гепатологии

Sheptulin Arkadiy A.

119991, Moscow

arkalshep@gmail.comhttps://orcid.org/0000-0002-5116-2144КардашеваC. C.KardashevaS. S.

Кардашева Светлана Станиславовна — канд. мед. наук, доцент кафедры пропедевтики внутренних болезней, гастроэнтерологии и гепатологии

Kardasheva Svetlana S.

119991, Moscow

https://orcid.org/0000-0002-6154-8163КурбатоваА. А.KurbatovaA. A.

Курбатова Анастасия Александровна  — канд. мед. наук, ассистент кафедры пропедевтики внутренних болезней, гастроэнтерологии и гепатологии 

Kurbatova Anastasia A.

119991, Moscow

ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)РоссияI.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)Russian Federation2022301020221007-8341345Copyright © Шептулин А.А., Кардашева C.C., Курбатова А.А., 20222022Шептулин А.А., Кардашева C.C., Курбатова А.А.Sheptulin A.A., Kardasheva S.S., Kurbatova A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.clinmedjournal.com/jour/article/view/422

В статье обсуждаются патогенетические и клинические аспекты желудочно-кишечных кровотечений (ЖКК) у больных новой коронавирусной инфекцией (COVID-19). Показана возможность непосредственного взаимодействия коронавируса с рецепторами ангиотензинпревращающего фермента-2 (АПФ-2) слизистой оболочки желудочно-кишечного тракта (ЖКТ) с развитием ее повреждения и последующего кровотечения. Значение антикоагулянтной терапии как фактора риска возникновения ЖКК оценивается противоречиво. У большинства больных с инфекцией COVID-19 и ЖКК консервативная гемостатическая терапия оказывается эффективной. Влияние ЖКК на течение и прогноз новой коронавирусной инфекции имеет неоднозначную трактовку. Учитывая недостаточную изученность патогенетических и клинических аспектов ЖКК у больных с инфекцией COVID-19, эта проблема требует дальнейших исследований.

The article discusses the pathogenetic and clinical aspects of gastrointestinal bleeding (GIB) in patients with a novel coronavirus infection (COVID-19). The possibility of direct interaction of the coronavirus with the receptors of the angiotensinconverting enzyme 2 (ACE-2) of the mucous membrane of the gastrointestinal tract with the development of its damage and subsequent bleeding has been shown. The value of anticoagulant therapy as a risk factor for the occurrence of GIB is evaluated inconsistently. In most patients with COVID-19 infection and GIB conservative hemostatic therapy is eff ective. The infl uence of GIB on the course and prognosis of a novel coronavirus infection has an contradictory interpretation. Given the lack of knowledge of the pathogenetic and clinical aspects of GIB in patients with COVID-19 infection, this problem requires further research.

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The authors declare that there are no conflicts of interest present.