clinmedКлиническая медицинаClinical Medicine (Russian Journal)0023-21492412-1339ООО «Медицинское информационное агентство»10.34651/0023-2149-2020-98-1-9-12clinmed-4Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESВозрастные изменения системы гемостазаAge-related changes in the hemostasis systemhttps://orcid.org/0000-0002-8396-1936КрюковЕ. В.KryukovE. V.

Крюков Евгений Владимирович — д-р мед. наук, проф., член-корр. РАН, начальник госпиталя

105094, Москва 

SPIN: 3900-3441

Eugeniy V. Kryukov — MD, PhD, DSc, professor, corresponding member RAS, head of the hospital

Moscow 

evgeniy.md@mail.ruhttps://orcid.org/0000-0002-5290-156XПаневинТ. С.PanevinT. S.

105094, Москва

SPIN-код: 7839-3145

https://orcid.org/0000-0002-3496-6466ПоповаЛ. В.PopovaL. V.

119991, Москва

SPIN-код: 1251-9273

ФГБУ «Главный военный клинический госпиталь им. акад. Н.Н. Бурденко» Министерства обороны РоссииРоссияBurdenko Main Military Clinical HospitalRussian FederationФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» (Сеченовский Университет) Минздрава РоссииРоссияI.M. Sechenov First Moscow State Medical UniversityRussian Federation202014072020981912Copyright © Крюков Е.В., Паневин Т.С., Попова Л.В., 20202020Крюков Е.В., Паневин Т.С., Попова Л.В.Kryukov E.V., Panevin T.S., Popova L.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.clinmedjournal.com/jour/article/view/4

Инфаркт миокарда, инсульт и венозный тромбоэмболизм, в основе которых лежит тромбоз сосудов, являются ведущими причинами смерти населения. Наиболее часто эти заболевания развиваются при старении организма человека. С возрастом происходят такие изменения в системе гемокоагуляции, как повышение уровня фибриногена, факторов VIII и IX и других прокоагулянтов без пропорционального увеличения количества антикоагулянтных факторов, уменьшение количества тромбоцитов и повышение их активности, снижение активности фибринолиза, развивается эндотелиальная дисфункция. Все это приводит к повышению интенсивности внутрисосудистого свертывания крови и развитию тромбозов.

Myocardial infarction, stroke and venous thromboembolism, which are based on vascular thrombosis, are the leading causes of death in the entire world. Most often, these diseases develop with the aging of the human body. With age, changes in the hemocoagulation system occur, such as an increase in the level of fibrinogen, factors VIII and IX and other procoagulants without a proportional increase in anticoagulant factors, a decrease in the number of platelets and an increase in their activity, a decrease in the activity of fibrinolysis, and endothelial dysfunction develops. All this leads to an increase in the intensity of intravascular coagulation and the development of thrombosis.

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The authors declare that there are no conflicts of interest present.