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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">clinmed</journal-id><journal-title-group><journal-title xml:lang="ru">Клиническая медицина</journal-title><trans-title-group xml:lang="en"><trans-title>Clinical Medicine (Russian Journal)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0023-2149</issn><issn pub-type="epub">2412-1339</issn><publisher><publisher-name>ООО «Медицинское информационное агентство»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.30629/0023-2149-2021-99-7-8-440-443</article-id><article-id custom-type="elpub" pub-id-type="custom">clinmed-287</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL INVESTIGATIONS</subject></subj-group></article-categories><title-group><article-title>Острый коронарный синдром у пациентов моложе 35 лет</article-title><trans-title-group xml:lang="en"><trans-title>Acute coronary syndrome in patients under 35 years old</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6027-2898</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бочаров</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Bocharov</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бочаров Александр Владимирович, д-р мед. наук</p><p>156013, Кострома; 362001, Владикавказ</p></bio><bio xml:lang="en"><p>156013, Kostroma; 362001, Vladikavkaz</p></bio><email xlink:type="simple">bocharovav@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0530-3268</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Попов</surname><given-names>Л. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Popov</surname><given-names>L. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Попов Леонид Валентинович, д-р мед. наук, профессор</p><p>105203, Москва</p></bio><bio xml:lang="en"><p>105203, Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5814-0060</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Митциев</surname><given-names>А. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Mittsiev</surname><given-names>A. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Митциев Астан Керменович, д-р мед. наук, профессор</p><p>362001, Владикавказ; 362019, Владикавказ</p></bio><bio xml:lang="en"><p>362001, Vladikavkaz; 362019, Vladikavkaz</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5773-6196</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лагкуев</surname><given-names>М. Дж.</given-names></name><name name-style="western" xml:lang="en"><surname>Lagkuev</surname><given-names>M. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лагкуев Магомет Джабраилович</p><p>362001, Владикавказ</p></bio><bio xml:lang="en"><p>362001, Vladikavkaz</p></bio><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ОГБУЗ «Костромская областная клиническая больница имени Королева Е.И.»; ГБУЗ Республиканская клиническая больница Министерства здравоохранения РСО-Алания</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kostroma Regional Clinical Hospital named after Korolev E.I.; Republican Clinical Hospital of the Ministry of Health of the Republic of North Ossetia-Alania</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБУ «Национальный медико-хирургический центр имени Н.И. Пирогова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National Medical and Surgical Center named after Pirogov N.I. of the Ministry of Healthcare of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ГБУЗ Республиканская клиническая больница Министерства здравоохранения РСО-Алания; ФГБОУ ВО «Северо-Осетинская государственная медицинская академия» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Republican Clinical Hospital of the Ministry of Health of the Republic of North Ossetia-Alania; North-Ossetian State Medical Academy</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ГБУЗ Республиканская клиническая больница Министерства здравоохранения РСО-Алания</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Republican Clinical Hospital of the Ministry of Health of the Republic of North Ossetia-Alania</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>05</day><month>01</month><year>2022</year></pub-date><volume>99</volume><issue>7-8</issue><fpage>440</fpage><lpage>443</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Бочаров А.В., Попов Л.В., Митциев А.К., Лагкуев М.Д., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Бочаров А.В., Попов Л.В., Митциев А.К., Лагкуев М.Д.</copyright-holder><copyright-holder xml:lang="en">Bocharov A.V., Popov L.V., Mittsiev A.K., Lagkuev M.D.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.clinmedjournal.com/jour/article/view/287">https://www.clinmedjournal.com/jour/article/view/287</self-uri><abstract><sec><title>Цель работы</title><p>Цель работы. Оценить клинико-демографические характеристики группы пациентов моложе 35 лет, поступивших с острым коронарным синдромом, а также особенности поражения коронарного русла и эндоваскулярного лечения.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. Проведен ретроспективный анализ группы пациентов в возрасте от 30 до 35 лет включительно, поступивших в Региональный сосудистый центр с диагнозом острый коронарный синдром (ОКС) в период с 2019 по июнь 2021 г. В исследование были включены 72 пациента с ОКС вне зависимости от наличия изменений сегмента ST на электрокардиограмме, поступивших по направлению скорой медицинской помощи. У всех пациентов определялись положительные тропонины при качественном анализе. При поступлении все пациенты направлялись в катетеризационную лабораторию, проводилось обследование согласно рекомендациям оказания медицинской помощи, а также выполнялась селективная коронарография и, при наличии показаний, стентирование коронарных артерий.</p></sec><sec><title>Результаты</title><p>Результаты. При анализе клинико-демографических характеристик группы обращают на себя внимание абсолютное преобладание лиц мужского пола — 71 (98,7%), городских жителей — 64 (88,9%), низкая частота вредных привычек: табакокурение у 13 (18,1%) и злоупотребление алкоголем у 2 (2,8%) пациентов, отсутствие сопутствующей патологии, значительное время от появления симптомов до вызова скорой медицинской помощи (165 [90; 263]). По результатам ангиографии следует отметить возможность возникновения острого коронарного синдрома при интактных коронарных артериях: 9 (27,3%) среди всех случаев ОКС с подъемом сегмента ST и 29 (74,3%) при ОКС без подъема сегмента ST, при этом в трети вышеописанных эпизодов (13 (34,2%)) причиной ОКС явилось наличие мышечного «мостика» в бассейне передней нисходящей артерии сопутствующим феноменом замедленного кровотока. Также обращают внимание практически равные доли острой тромботической окклюзии (19 (55,9%)) и гемодинамически значимого стенотического поражения (14 (41,2%)) как причины возникновения ОКС.</p></sec><sec><title>Заключение</title><p>Заключение. У пациентов младше 35 лет с типичной клинической картиной, положительными тропонинами при качественном анализе имеется высокая вероятность наличия патологических изменений в коронарном русле вне зависимости от наличия изменений сегмента ST, что требует выполнения рентгенэндоваскулярных методов диагностики и лечения. Ангиографическими особенностями поражения коронарного русла у молодых являются дискретность поражения в проксимальных или средних отделах артерий, высокая частота тромботических окклюзий, преимущественное поражение передней нисходящей или правой коронарной артерий, низкая частота кальциноза коронарных артерий.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Objective</title><p>Objective. To evaluate the clinical and demographic characteristics of a group of patients under 35 years old admitted with acute coronary syndrome, as well as the features of coronary bed damage and endovascular treatment.</p></sec><sec><title>Material and methods</title><p>Material and methods. A retrospective analysis of the group of patients aged 30 to 35, admitted to the Regional Vascular Center with a diagnosis of acute coronary syndrome in the period from 2019 to June 2021, was carried out. The study included 72 patients with ACS, regardless of the ST segment changes on the electrocardiogram, were admitted to the hospital by the emergency medical service referral. Positive troponins were detected in all the patients by qualitative analysis. Upon admission, they were sent to a catheterization laboratory. An examination was carried out according to the recommendations of medical care, as well as selective coronary angiography and, if indicated, stenting of the coronary arteries was performed.</p></sec><sec><title>Results</title><p>Results. When analyzing the clinical and demographic characteristics of the group, attention has been drawn to the absolute predominance of males — 71 (98.7%), urban residents — 64 (88.9%), low frequency of bad habits: tobacco smoking in 13 (18.1%) and alcohol abuse in 2 (2.8%) patients, the absence of concomitant pathology, a signifi cant time from the onset of symptoms to calling an ambulance (165 [90; 263]). According to the results of angiography, it should be noted the possibility of acute coronary syndrome with intact coronary arteries is 9 (27.3%) among all ACS cases with ST segment elevation and 29 (74.3%) with ACS without ST segment elevation, while in one third of the above episodes (13 (34.2%)) ACS was caused by the presence of a muscle “bridge” in the basin of the anterior descending artery, a concomitant phenomenon of slowed blood fl ow. The attention has been also drawn to the almost equal proportions of acute thrombotic occlusion (19 (55.9%)) and haemodynamically signifi cant hemadostenosis (14 (41.2%)) as the cause of ACS.</p></sec><sec><title>Conclusion</title><p>Conclusion. In patients under 35 years old with a typical clinical. picture, positive troponins, with a qualitative analysis, there is a high probability of pathological changes in the coronary bed, regardless of the ST segment changes, which requires X-ray endovascular methods of diagnosis and treatment. Angiographic features of the coronary artery lesion in young people are the discreteness of the lesion in the proximal or middle sections of the arteries, the high frequency of thrombotic occlusions, the predominant lesion of the anterior descending or right coronary arteries, the low frequency of calcifi cation of the coronary arteries.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>острый коронарный синдром</kwd><kwd>молодой возраст</kwd><kwd>чрескожные коронарные вмешательства</kwd></kwd-group><kwd-group xml:lang="en"><kwd>acute coronary syndrome</kwd><kwd>young age</kwd><kwd>percutaneous coronary interventions</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Feijo J.P., Schmidt M.M., David R.B. et al. Clinical profi le and outcomes of primary percutaneous coronary intervention in young patients. Rev. Bras. Cardiol. Invasiva. 2015;23(1):48–51. 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