clinmedКлиническая медицинаClinical Medicine (Russian Journal)0023-21492412-1339ООО «Медицинское информационное агентство»10.30629/0023-2149-2020-98-2-115-121clinmed-20Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL INVESTIGATIONSКлинико-морфологическая характеристика инфекционного эндокардитаClinical and morphological characteristics of infective endocarditisУлановаВ. И.UlanovaV. I.

Уланова Вероника Ивановна — д-р мед. наук, доцент кафедры терапии и ревматологии им. Э.Э. Эйхвальда

 191015, Санкт-Петербург

viu5@yandex.ruМазуровВ. И.MazurovV. I.

197341, Санкт-Петербург

197341, Saint Petersburg

ЦинзерлингВ. А.ZinzerlingV. A.

197341, Санкт-Петербург

197341, Saint Petersburg

ФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава РоссииРоссияI.I. Mechnikov North-Western State Medical UniversityRussian FederationФГБУ «Национальный медицинский исследовательский центр имени В.А. Алмазова»РоссияV.A. Almazov National Medical Research CenterRussian Federation202014072020982115121Copyright © Уланова В.И., Мазуров В.И., Цинзерлинг В.А., 20202020Уланова В.И., Мазуров В.И., Цинзерлинг В.А.Ulanova V.I., Mazurov V.I., Zinzerling V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.clinmedjournal.com/jour/article/view/20

Цель исследования — выявление особенностей клинического течения и морфогенеза инфекционного эндокардита (ИЭ) у ВИЧ-инфицированных инъекционных наркоманов с сопутствующим гепатитом С в сопоставлении с клиникоморфологической картиной эндокардита у лиц без наркотической зависимости. Установлено, что возбудителем ИЭ у ВИЧ-инфицированных больных являлся золотистый стафилококк (71,8%), а у лиц без наркотической зависимости в этологии заболевания преобладала условно-патогенная флора. У ВИЧинфицированных наркозависимых больных было выявлено поражение трехстворчатого клапана (82,7%), а у лиц без наркотической зависимости изолированное поражение аортального клапана (40%) и сочетанные поражения митрального и аортального клапанов (36,4%). Осложнения гнойно-экссудативного характера у наркозависимых больных ИЭ встречаются реже, чем у пациентов без наркотической зависимости в связи с иммуносупрессией, имеющейся у ВИЧ-инфицированых лиц.

The aim of the study was to identify the features of the clinical course and morphogenesis of infective endocarditis (IE) in HIVinfected injecting drug users with concomitant hepatitis C virus infection in comparison with the clinical and morphological picture of endocarditis in persons without drug dependence. It was found that the causative agent of IE in HIV-infected patients was staphylococcus aureus (71.8%), and in persons without drug dependence in the etiology of the disease the conditionally pathogenic flora prevailed. In HIV-infected drug-dependent patients, the tricuspid valve was affected (82.7%), and in persons without drug dependence — isolated aortic valve damage (40%) and combined mitral and aorticvalve lesions (36.4%). Purulent sepsis complications in drug-dependent patients with IE are less common than in patients without drug dependence due to immunosuppression, which is present in HIV-infected persons.

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The authors declare that there are no conflicts of interest present.