clinmedКлиническая медицинаClinical Medicine (Russian Journal)0023-21492412-1339ООО «Медицинское информационное агентство»10.30629/0023-2149-2026-104-6-434-438clinmed-1492Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESНедостаточность витамина D и его роль в развитии сердечно-сосудистых заболеванийVitamin D deficiency and its role in the development of cardiovascular diseaseshttps://orcid.org/0000-0003-2757-0671КинванлунИ. Г.KinvanlunI. G.

Ибрагим Гадирович Кинванлун — канд. мед. наук, врач кардиолог-сомнолог, старший преподаватель кафедры терапии 2

Бишкек

Ibrahim G. Kinvanlun — Candidate of Medical Sciences, cardiologistsomnologist, senior lecturer at the Department of Therapy 2

 

kin.ibragim@mail.ruЗемлянаяН. Е.ZemlyanayaN. E.

Нина Евгеньевна Земляная — врач лимфолог, преподаватель кафедры дерматовенерологии и фтизиатрии

Бишкек

Nina E. Zemlyanaya — lymphologist, lecturer at the Department of Dermatovenerology and Phthisiology

 

МОО ВО «Кыргызско-Российский Славянский университет имени первого президента РФ Б.Н. Ельцина»КыргызстанKyrgyz Russian Slavic University named after the fi rst President of the Russian Federation B.N. YeltsinKyrgyzstan2026280820261046434438Copyright © Кинванлун И.Г., Земляная Н.Е., 20262026Кинванлун И.Г., Земляная Н.Е.Kinvanlun I.G., Zemlyanaya N.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.clinmedjournal.com/jour/article/view/1492

Сердечно-сосудистые заболевания (ССЗ) — ведущая причина смертности в мире. В настоящем обзоре анализируется роль недостаточности витамина D как фактора риска ССЗ, включая артериальную гипертензию (АГ), коронарную болезнь сердца (КБС), сердечную недостаточность (СН) и инсульт. Недостаточность витамина D (25(OH)D < 30 нг/мл) встречается у 30–50% населения, особенно в регионах с низкой инсоляцией. Эпидемиологические данные подтверждают рост риска ССЗ в 1,5–2 раза при низком уровне витамина D. Патофизиологические механизмы включают эндотелиальную дисфункцию, воспаление, дислипидемию и активацию ренин-ангиотензин-альдостероновой системы. Клинические исследования (VITAL, D-Health) показывают противоречивые результаты: прием витамина D эффективен только в группах с выраженным дефицитом. Необходимы дальнейшие исследования для разработки персонализированных подходов к профилактике ССЗ.

Cardiovascular diseases (CVD) are the leading cause of death in the world. This review analyzes the role of vitamin D deficiency as a risk factor for CVD, including hypertension, coronary heart disease, heart failure, and stroke. Vitamin D defi ciency (25(OH) D < 30 ng/ml) occurs in 30–50% of the population, especially in regions with low insolation. Epidemiological data confi rm a 1.5–2-fold increase in the risk of CVD with low vitamin D levels. Pathophysiological mechanisms include endothelial dysfunction, infl ammation, dyslipidemia, and activation of the renin-angiotensin-aldosterone system. Clinical studies (VITAL, D-Health) show contradictory results: taking vitamin D is eff ective only in groups with severe deficiency. Further research is needed to develop personalized approaches to CVD prevention.

Material and methods. A review of the scientific literature (2014–2025) was conducted based on a search in the PubMed, Scopus, and eLibrary databases. Data from meta-analyses, large cohort studies (Framingham, Rotterdam), and randomized controlled trials (VITAL, D-Health) were analyzed. The sources were selected based on the criteria of relevance, design quality, and evidence.

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The authors declare that there are no conflicts of interest present.