clinmedКлиническая медицинаClinical Medicine (Russian Journal)0023-21492412-1339ООО «Медицинское информационное агентство»10.30629/0023-2149-2025-103-2-104-107clinmed-1383Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESЭпигенетические механизмы кардиопротекторного влияния физических упражненийEpigenetic mechanisms of the cardioprotective effects of physical exercisehttps://orcid.org/0000-0003-4973-039XАйтбаевК. А.AitbaevK. A.

Айтбаев Кубаныч Авенович — д-р мед. наук, профессор, главный консультант отдела реанимации, терапии и диагностики «Салымбеков Университет».

Бишкек

Kubanych A. Aitbaev — Doctor of Medical Sciences, Professor, Chief Consultant of the Department of Intensive Care, Therapy and Diagnostics.

Bishkek

https://orcid.org/0000-0001-8513-9279МуркамиловИ. Т.MurkamilovI. T.

Муркамилов Илхом Торобекович — д-р мед. наук, член-корр. РАЕ, доцент кафедры факультетской терапии КГМА им. И.К. Ахунбаева; руководитель отдела реанимации, терапии и диагностики «Салымбеков Университет».

Бишкек

Ilkhom T. Murkamilov — Ilkhom Torobekovich Murkamilov — Doctor of Medical Sciences, Corresponding Member of the Russian Academy of Medical Sciences, Associate Professor of the Department of Faculty Therapy at the I.K. Akhunbayev KSMU; Head of the Department of Intensive Care, Therapy and Diagnostics at Salymbek University.

Bishkek

murkamilov.i@mail.ruhttps://orcid.org/0000-0002-2682-4417ФоминВ. В.FominV. V.

Фомин Виктор Викторович — д-р мед. наук, профессор, академик РАН, ректор.

Москва

Viktor V. Fomin — Doctor of Medical Sciences, Professor, Academician of the Russian Academy of Sciences, Rector.

Moscow

https://orcid.org/0000-0003-0632-6653ЮсуповФ. А.YusupovF. A.

Юсупов Фуркат Абдулахатович — д-р мед. наук, профессор, заведующий кафедрой неврологии, нейрохирургии и психиатрии медицинского факультета ОшГУ.

Ош

Furkat A. Yusupov — Doctor of Medical Sciences, Professor, Head of the Department of Neurology, Neurosurgery and Psychiatry.

Osh

Салымбеков УниверситетКыргызстанI. Salymbekov UniversityKyrgyzstanСалымбеков Университет; Кыргызская государственная медицинская академия имени И.К. АхунбаеваКыргызстанI. Salymbekov University; I.K. Akhunbaev Kyrgyz State Medical AcademyKyrgyzstanФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования»РоссияI.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of the Russia (Sechenov University)Russian FederationОшский государственный университетРоссияOsh State UniversityRussian Federation2026190420261042104107Copyright © Айтбаев К.А., Муркамилов И.Т., Фомин В.В., Юсупов Ф.А., 20262026Айтбаев К.А., Муркамилов И.Т., Фомин В.В., Юсупов Ф.А.Aitbaev K.A., Murkamilov I.T., Fomin V.V., Yusupov F.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.clinmedjournal.com/jour/article/view/1383

Сердечно-сосудистые заболевания (ССЗ) остаются одной из ведущих причин заболеваемости и смертности во всем мире, причем их распространенность продолжает расти в связи со старением населения. Несмотря на убедительные доказательства эффективности физических упражнений в снижении риска ССЗ, молекулярные механизмы, лежащие в основе этого эффекта, до сих пор недостаточно изучены. В последние годы все больше исследований указывают на ключевую роль эпигенетических механизмов, таких как метилирование ДНК, модификации гистонов и экспрессия некодирующих РНК, в регуляции сердечно-сосудистого здоровья. Физическая активность выступает мощным эпигенетическим модулятором, вызывая устойчивые изменения экспрессии генов и активируя сигнальные пути, связанные с функцией сердечно-сосудистой системы. В данном мини-обзоре представлены актуальные данные о влиянии физических упражнений на экспрессию длинных некодирующих РНК и их роль в патогенезе и профилактике ССЗ. Современные исследования подтверждают, что эпигенетические модификации, индуцированные физической активностью, обладают значительным терапевтическим потенциалом в профилактике и лечении ССЗ.

Cardiovascular diseases (CVD) remain one of the leading causes of morbidity and mortality worldwide, with their prevalence continuing to rise due to population aging. Despite compelling evidence supporting the effectiveness of physical exercise in reducing CVD risk, the molecular mechanisms underlying these protective effects remain insufficiently understood. In recent years, an increasing number of studies have highlighted the key role of epigenetic mechanisms, including DNA methylation, histone modifications, and non-coding RNA expression, in regulating cardiovascular health. Physical activity serves as a potent epigenetic modulator, inducing long-lasting changes in gene expression and activating signaling pathways associated with cardiovascular function. This mini-review presents current data on the impact of physical exercise on long non-coding RNA expression and their role in the pathogenesis and prevention of CVD. Recent studies confirm that epigenetic modifications induced by physical activity hold significant therapeutic potential for the prevention and treatment of CVD.

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The authors declare that there are no conflicts of interest present.