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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">clinmed</journal-id><journal-title-group><journal-title xml:lang="ru">Клиническая медицина</journal-title><trans-title-group xml:lang="en"><trans-title>Clinical Medicine (Russian Journal)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0023-2149</issn><issn pub-type="epub">2412-1339</issn><publisher><publisher-name>ООО «Медицинское информационное агентство»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.30629/0023-2149-2025-103-12-885-892</article-id><article-id custom-type="elpub" pub-id-type="custom">clinmed-1335</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL INVESTIGATIONS</subject></subj-group></article-categories><title-group><article-title>Особенности течения новой коронавирусной инфекции у пациентов с бронхиальной астмой и аллергическими реакциями</article-title><trans-title-group xml:lang="en"><trans-title>Features of the course of the new coronavirus infection in patients with bronchial asthma and allergic reactions</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тамбовская</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Tambovskaya</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Тамбовская Анастасия Сергеевна — cтудентка 6-го курса  </p><p>Тула</p></bio><bio xml:lang="en"><p>Anastasia S. Tambovskaya — 6th year student </p><p>Tula </p></bio><email xlink:type="simple">nikolaeva0973@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Клюкина</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Klyukina</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Клюкина Валерия Андреевна — cтудентка 6-го курса  </p><p>Тула</p></bio><bio xml:lang="en"><p>Valeria A. Klyukina — 6th year student  </p><p>Tula </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Нехаев</surname><given-names>С. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Nekhaev</surname><given-names>S. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Нехаев Сергей Геннадьевич — канд. мед. наук, доцент кафедры инфекционных болезней </p><p>Тула</p></bio><bio xml:lang="en"><p>Sergey G. Nekhaev — Candidate of Medical Sciences, Associate Professor of the Department of Infectious Diseases</p><p>Tula </p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Тульский государственный университет»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Tula State University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>03</day><month>03</month><year>2026</year></pub-date><volume>103</volume><issue>12</issue><fpage>885</fpage><lpage>892</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Тамбовская А.С., Клюкина В.А., Нехаев С.Г., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Тамбовская А.С., Клюкина В.А., Нехаев С.Г.</copyright-holder><copyright-holder xml:lang="en">Tambovskaya A.S., Klyukina V.A., Nekhaev S.G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.clinmedjournal.com/jour/article/view/1335">https://www.clinmedjournal.com/jour/article/view/1335</self-uri><abstract><p>Высокая патогенность SARS-CoV-2 и аэрогенный механизм передачи являются проблемой общественного здравоохранения. Сначала считалось, что наличие в анамнезе аллергических реакций усугубляло течение болезни. Позже выяснилось, что бронхиальная астма (БА) у пациентов или другие аллергические заболевания не влияли на степень тяжести коронавирусной инфекции (КВИ).</p><sec><title>Цель работы</title><p>Цель работы: выявление зависимости течения COVID-19 у пациентов с БА и аллергиями.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. В результате поперечного исследования гипотезы был проведен ретроспективный анализ пациентов за 2019–2023 гг. Группа исследования — пациенты с подтвержденной КВИ, находящиеся на диспансерном учете по БА, пациенты с подтвержденной КВИ и наличием в анамнезе аллергий. Для оценки тяжести течения заболевания взяты лабораторные показатели больных в динамике и симптомы заболевания.</p></sec><sec><title>Результаты</title><p>Результаты. У пациентов с КВИ уровень СОЭ ниже, чем у больных с сопутствующей БА и аллергиями. Показатели СРБ у женщин с отягощенным анамнезом повышены в отличие от пациентов только с КВИ. У мужчин существенных различий в результатах СРБ не выявлено.</p></sec><sec><title>Заключение</title><p>Заключение. У женщин и мужчин с КВИ и сопуствующей БА и/или с отягощенным аллергическим анамнезом — по данным лабораторных показателей и особенностям клинической картины — наблюдалось более легкое течение по сравнению с больными КВИ без сопутствующих заболеваний.</p></sec></abstract><trans-abstract xml:lang="en"><p>The high pathogenicity of SARS-CoV-2 and the airborne transmission mechanism are a public health concern. At first, it was believed that a history of allergic reactions aggravated the course of the disease. Later, it turned out that bronchial asthma (BA) in patients or other allergic diseases did not affect the severity of coronavirus infection (CVI).</p><sec><title>Objective</title><p>Objective. The aim of the study is to identify the relationship between the course of COVID-19 in patients with asthma and allergies.</p></sec><sec><title>Material and methods</title><p>Material and methods. As a result of the cross-sectional study of the hypothesis, a retrospective analysis of people was conducted for the years 2019–2023. The study group — patients with confirmed COVID-19 and the presence of dispensary registration for bronchial asthma, patients with confirmed COVID-19 and a history of allergies. To assess the severity of the disease, laboratory parameters of patients in dynamics and symptoms were taken.</p></sec><sec><title>Results</title><p>Results. Women with COVID-19 have lower ESR levels than women with concomitant asthma and allergies; men have identical results. The CRP indicators in women with an aggravated anamnesis increase sharply, in contrast to individuals with COVID-19. In men, no significant differences in the CRP results were found.</p></sec><sec><title>Conclusion</title><p>Conclusion. In women and men with bronchial asthma and/or a history of allergies, the course of COVID-19 was milder, both according to laboratory data and the corresponding clinical picture.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>COVID-19</kwd><kwd>коронавирусная инфекция SARS-CoV-2</kwd><kwd>коронавирусная инфекция</kwd><kwd>аллергические реакции</kwd><kwd>аллергии</kwd><kwd>бронхиальная астма</kwd></kwd-group><kwd-group xml:lang="en"><kwd>COVID-19</kwd><kwd>SARS-CoV-2 coronavirus infection</kwd><kwd>coronavirus infection</kwd><kwd>allergic reactions</kwd><kwd>allergies</kwd><kwd>bronchial asthma</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Kolifarhood G., Aghaali M., Mozafar Saadati H., Taherpour N., Rahimi S., Izadi N. et al. 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