clinmedКлиническая медицинаClinical Medicine (Russian Journal)0023-21492412-1339ООО «Медицинское информационное агентство»10.30629/0023-2149-2020-98-8-583-587clinmed-119Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESЯзвенная болезнь: что в ней изменилось за последние 50 лет?Peptic ulcer disease: changes it has undergone over the past 50 yearshttps://orcid.org/0000-0002-1395-9566ШептулинА. А.SheptulinA. A.

Шептулин Аркадий Александрович — д-р мед. наук, проф. каф. пропедевтики внутренних болезней, гастроэнтерологии и гепатологии  

11999, Москва

Arkadiy A.Sheptulin — MD, PhD, DSc, prof. Dpt. of Propedeutics of Internal Disease, Gastroenterology and Hepatology

11999, Moscow

arkalshep@gmail.comhttps://orcid.org/0000-0002-5116-2144КардашеваС. С.KardashevaS. S.

11999, Москва

11999, Moscow

https://orcid.org/0000-0002-6154-8163КурбатоваА. А.KurbatovaA. A.

11999, Москва

11999, Moscow

ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» (Сеченовский университет) Минздрава РоссииРоссияI.M. Sechenov First Moscow State Medical University (Sechenov University) Ministry of Health of RussiaRussian Federation202007022021988583587Copyright © Шептулин А.А., Кардашева С.С., Курбатова А.А., 20212021Шептулин А.А., Кардашева С.С., Курбатова А.А.Sheptulin A.A., Kardasheva S.S., Kurbatova A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.clinmedjournal.com/jour/article/view/119

В представленном обзоре рассматриваются основные изменения наших представлений, касающихся этиологии язвенной болезни, ее лечения и профилактики. Подчеркивается, что открытие инфекции Hеlicobacter pylori и проведение ее эрадикации не решило всех вопросов, связанных с язвенной болезнью. Требуют своего изучения вопросы патогенеза идиопатических гастродуоденальных язв, а также язвенных поражений, вызванных приемом лекарственных препаратов (в частности, нестероидных противовоспалительных препаратов).

This review considers the main changes in our understanding of the etiology of peptic ulcer disease (PUD), its treatment and prevention. It is emphasized that the discovery of H. pylori infection and the implementation of eradication therapy did not solve all the issues related to PUD. Further investigation is needed to study the pathogenesis of idiopathic gastroduodenal ulcers, as well as ulcerative lesions of the stomach and duodenum, caused by various medications (non-steroidal anti-inflammatory drugs in particular).

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The authors declare that there are no conflicts of interest present.