clinmedКлиническая медицинаClinical Medicine (Russian Journal)0023-21492412-1339ООО «Медицинское информационное агентство»10.30629/0023-2149-2025-103-3-187-195clinmed-1093Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESФибриновый клей в хирургической практикеClinical application of fi brin sealanthttps://orcid.org/0000-0002-6147-7887КванО. К.KvanO. K.

Кван Оксана Климентиевна — заведующая отделением клинической и производственной трансфузиологии

Москва

Oksana K. Kvan — Head of Clinical and Productional Transfusion Department

Moscow

https://orcid.org/0000-0001-8535-8535ТеряеваН. Б.TeryaevaN. B.

Теряева Надежда Борисовна — канд. мед. наук, врач клинической лабораторной диагностики

Москва

Nadezhda B. Teryaeva — PhD, сlinical laboratory diagnostics doctor

Moscow

NTeryaeva@nsi.ruФГАУ «Национальный медицинский исследовательский центр нейрохирургии им. акад. Н.Н. Бурденко» Минздрава РоссииРоссияNational Medical Research Center for Neurosurgery named after Academician N.N. BurdenkoRussian Federation2025030720251033187195Copyright © Кван О.К., Теряева Н.Б., 20252025Кван О.К., Теряева Н.Б.Kvan O.K., Teryaeva N.B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.clinmedjournal.com/jour/article/view/1093

Фибриновый клей (ФК) в хирургической практике применяется достаточно давно и является одним из инструментов для достижения гемостаза и профилактики периоперационного кровотечения. Выбор ФК при различных хирургических стратегиях влияет на клинический результат. Многочисленные исследования биологических и синтетических клеевых композиций показывают, что все еще имеется ограниченное количество данных о том, как тонкие различия в рецептурах фибриновых герметиков связаны с их клинической эффективностью и безопасностью. В этом обзоре мы попытались обобщить сведения по биологическим адгезивам — ФК, проследить историю внедрения в хирургическую практику ФК, осветить механизмы гелеобразования и адгезии, определяющие герметизирующие функции, изменение рецептуры составляющих клеевых композиций, а также проследить причины, побуждающие исследователей к поиску новых решений. Рассмотрены альтернативные технологии производства ФК, их преимущества и недостатки с учетом особенностей хирургического применения

Fibrin sealants in surgery has been used for a long time as a tool for hemostasis and perioperative bleeding preventing. The appropriateness of fi brin glue to diff erent surgical strategies infl uences the clinical outcome. Numerous studies on biological and synthetic adhesive compositions show that there is still limited data on how diff erences in fi brin sealant formulations relate to their clinical eff ectiveness and safety. The review is an attempt to summarize information on biological adhesives including the history of implementation of fi brin glue in surgery, gelation and adhesion mechanisms that determine the bioadhesive properties and sealing functions, the development of adhesive composition formulations, and the reasons prompting researchers to new solutions are also discussed. Alternative technologies, their advantages and disadvantages taking into account surgical strategies, are considered

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The authors declare that there are no conflicts of interest present.